1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes.

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:We investigated both the structural and functional consequences of modifying the hydrophobic, lipopeptide-mimetic oligo-acyl-lysine (OAK) N(alpha)-hexadecanoyl-l-lysyl-l-lysyl-aminododecanoyl-l-lysyl-amide (c(16)KKc(12)K) to its unsaturated analog hexadecenoyl-KKc(12)K [c(16(omega7))KKc(12)K]. Despite similar tendenci...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarig H,Rotem S,Ziserman L,Danino D,Mor A

更新日期：2008-12-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:Clinical treatment failures have been reported to occur in early Lyme borreliosis (LB) for many suitable antimicrobial agents. Investigations of possible resistance mechanisms of the Borrelia burgdorferi complex must analyze clinical isolates obtained from LB patients, despite their receiving antibiotic treatment. Her...

journal_title：Antimicrobial agents and chemotherapy

authors： Hunfeld KP,Ruzic-Sabljic E,Norris DE,Kraiczy P,Strle F

更新日期：2005-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:The effects of amphotericin B and fluconazole on the extracellular and intracellular growth of Candida albicans were studied. With respect to the extracellular growth of C. albicans, antifungal activity was measured in terms of MICs and minimal fungicidal concentrations as well as by determination of the concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： van Etten EW,van de Rhee NE,van Kampen KM,Bakker-Woudenberg IA

更新日期：1991-11-01 00:00:00

abstract：:Halocidin is an antimicrobial peptide found in the tunicate. A series of experiments were previously conducted in an attempt to develop a novel antibiotic derived from halocidin, as the peptide was determined to evidence profound antimicrobial activity against a variety of antibiotic-resistant microbes, with significa...

journal_title：Antimicrobial agents and chemotherapy

authors： Jang WS,Lee SC,Lee YS,Shin YP,Shin KH,Sung BH,Kim BS,Lee SH,Lee IH

更新日期：2007-11-01 00:00:00

abstract：:Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular st...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarkar S,Uppuluri P,Pierce CG,Lopez-Ribot JL

更新日期：2014-01-01 00:00:00

abstract：:The discovery of quorum-sensing (QS) systems regulating antibiotic resistance and virulence factors (VFs) has afforded a novel opportunity to prevent bacterial pathogenicity. Dietary molecules have been demonstrated to attenuate QS circuits of bacteria. But, to our knowledge, no study exploring the potential of colost...

journal_title：Antimicrobial agents and chemotherapy

authors： Srivastava A,Singh BN,Deepak D,Rawat AK,Singh BR

更新日期：2015-04-01 00:00:00

abstract：:This phase 1, open-label, single-dose, parallel-group study evaluated the pharmacokinetics (PK) of isavuconazole after a single oral dose of the prodrug isavuconazonium sulfate in healthy nonelderly (age, 18 to 45 years) and elderly (age, ≥65 years) males and females. Overall, 48 subjects were enrolled in the study (n...

journal_title：Antimicrobial agents and chemotherapy

authors： Desai AV,Han D,Kowalski DL,Lademacher C,Pearlman H,Yamazaki T

更新日期：2019-05-24 00:00:00

abstract：:Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Korduláková J,Janin YL,Liav A,Barilone N,Dos Vultos T,Rauzier J,Brennan PJ,Gicquel B,Jackson M

更新日期：2007-11-01 00:00:00

abstract：:A total of 91 multiply resistant bacterial strains, including Klebsiella pneumoniae (32 strains), Pseudomonas aeruginosa (16 strains), and Serratia marcescens (43 strains), were collected during hospital epidemics of nosocomial infection from 1975 to 1979. These strains were resistant to gentamicin, tobramycin, cephal...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ,Gerding DN

更新日期：1980-02-01 00:00:00

abstract：:A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had hig...

journal_title：Antimicrobial agents and chemotherapy

authors： Brimacombe M,Hazbon M,Motiwala AS,Alland D

更新日期：2007-11-01 00:00:00

abstract：:No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Downey AS,Chong CR,Graczyk TK,Sullivan DJ

更新日期：2008-09-01 00:00:00

abstract：:We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

更新日期：2002-11-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals are thought to play a role in suppressing the HBV-specific immune response. Current therapeutics are not directed at reducing this viral antigenemia; thus, our group has focuse...

journal_title：Antimicrobial agents and chemotherapy

authors： Dougherty AM,Guo H,Westby G,Liu Y,Simsek E,Guo JT,Mehta A,Norton P,Gu B,Block T,Cuconati A

更新日期：2007-12-01 00:00:00

abstract：:We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate th...

journal_title：Antimicrobial agents and chemotherapy

authors： Baumann RJ,McCann PP,Bitonti AJ

更新日期：1991-07-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:CTX-M-type extended-spectrum beta-lactamases (ESBLs) have become increasingly common worldwide, with the notable exception of the United States, where TEM- and SHV-type ESBLs have appeared to predominate. We have noted the emergence of ESBLs in our health care system (the University Health System in San Antonio, TX), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis JS 2nd,Herrera M,Wickes B,Patterson JE,Jorgensen JH

更新日期：2007-11-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:Using an immunocompetent murine model of invasive aspergillosis (IA), we previously reported that the efficacy of liposomal amphotericin B (L-AmB) (Ambisome) is not hampered by the presence of azole resistance mutations in Aspergillus fumigatus (S. Seyedmousavi, W. J. G. Melchers, J. W. Mouton, and P. E. Verweij, Anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Seyedmousavi S,Mouton JW,Melchers WJG,Verweij PE

更新日期：2017-05-24 00:00:00

abstract：:Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus Here, we explored the MIC variability in more detail and prospectively investigated the susceptibili...

journal_title：Antimicrobial agents and chemotherapy

authors： Astvad KMT,Jørgensen KM,Hare RK,Datcu R,Arendrup MC

更新日期：2020-12-16 00:00:00

abstract：:Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefor...

journal_title：Antimicrobial agents and chemotherapy

authors： Berke JM,Vijgen L,Lachau-Durand S,Powdrill MH,Rawe S,Sjuvarsson E,Eriksson S,Götte M,Fransen E,Dehertogh P,Van den Eynde C,Leclercq L,Jonckers TH,Raboisson P,Nilsson M,Samuelsson B,Rosenquist Å,Fanning GC,Lin TI

更新日期：2011-08-01 00:00:00

abstract：:Cyclic peptides with an even number of alternating d,l-alpha-amino acid residues are known to self-assemble into organic nanotubes. Such peptides previously have been shown to be stable upon protease treatment, membrane active, and bactericidal and to exert antimicrobial activity against Staphylococcus aureus and othe...

journal_title：Antimicrobial agents and chemotherapy

authors： Dartois V,Sanchez-Quesada J,Cabezas E,Chi E,Dubbelde C,Dunn C,Granja J,Gritzen C,Weinberger D,Ghadiri MR,Parr TR Jr

更新日期：2005-08-01 00:00:00

abstract：:The entry of an antibiotic into phagocytes is a prerequisite for its intracellular bioactivity against susceptible facultative or obligatory intracellular microorganisms. Brodimoprim is a dimethoxybenzylpyrimidine that has recently entered into clinical use, and its uptake into and elimination from human polymorphonuc...

journal_title：Antimicrobial agents and chemotherapy

authors： Braga PC,Dal Sasso M,Maci S,Bondiolotti G,Fonti E,Reggio S

更新日期：1996-10-01 00:00:00

abstract：:Candida albicans and Staphylococcus aureus form vigorous polymicrobial biofilms in serum, which may serve as the source of coinfection in patients. More importantly, S. aureus is highly resistant to vancomycin during polymicrobial biofilm formation, with no decreases in bacterial viability observed with up to 1,600 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2010-09-01 00:00:00

abstract：:Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

更新日期：1973-05-01 00:00:00