Identification of a novel clone, ST736, among Enterococcus faecium clinical isolates and its association with daptomycin nonsusceptibility.

abstract：:Major facilitator superfamily (MFS) efflux pumps have been shown to be important for bacterial cells to cope with biocides such as chlorhexidine (CHX), a widely used molecule in hospital settings. In this work, we evaluated the role of two genes, smvA and smvR, in CHX resistance in Enterobacter cloacae complex (ECC). ...

journal_title：Antimicrobial agents and chemotherapy

authors： Guérin F,Gravey F,Plésiat P,Aubourg M,Beyrouthy R,Bonnet R,Cattoir V,Giard JC

更新日期：2019-12-20 00:00:00

abstract：:Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) on the Indian subcontinent. The mechanisms operating in laboratory-generated strains are somewhat known, but the determinants of clinical antimony resistance are not well understood. By utili...

journal_title：Antimicrobial agents and chemotherapy

authors： Ashutosh,Garg M,Sundar S,Duncan R,Nakhasi HL,Goyal N

更新日期：2012-01-01 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations that may be of clinical significance, especially during human immunodeficiency virus type 1 (HIV-1) and malaria coinfection. Using clinical isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lek-Uthai U,Suwanarusk R,Ruengweerayut R,Skinner-Adams TS,Nosten F,Gardiner DL,Boonma P,Piera KA,Andrews KT,Machunter B,McCarthy JS,Anstey NM,Price RN,Russell B

更新日期：2008-07-01 00:00:00

abstract：:Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, express a single polar flagellum powered by sodium motive force and require motility to colonize and spread along the small intestine. In a previous study, we described a high-throughput assay for screening for sm...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Zhang L,Silva AJ,Benitez JA

更新日期：2013-08-01 00:00:00

abstract：:One of the major neglected tropical diseases, schistosomiasis, is currently treated and controlled with a single drug, praziquantel. The quest for an alternative drug is fueled by the lack of activity of praziquantel against juvenile Schistosoma worms and the fear of emerging resistance. The synthetic ozonide OZ418 ha...

journal_title：Antimicrobial agents and chemotherapy

authors： Leonidova A,Vargas M,Huwyler J,Keiser J

更新日期：2016-11-21 00:00:00

abstract：:With the emergence of multidrug-resistant mycobacterial strains, better therapeutic strategies are required for the successful treatment of the infection. Although antimicrobial peptides (AMPs) and silver nanoparticles (AgNPs) are becoming one of the popular antibacterial agents, their antimycobacterial potential is n...

journal_title：Antimicrobial agents and chemotherapy

authors： Mohanty S,Jena P,Mehta R,Pati R,Banerjee B,Patil S,Sonawane A

更新日期：2013-08-01 00:00:00

abstract：:Retrocyclins are humanized versions of the -defensin peptides expressed by the leukocytes of several nonhuman primates. Previous studies, performed in serum-free media, determined that retrocyclins 1 (RC1) and RC2 could prevent successful germination of Bacillus anthracis spores, kill vegetative B. anthracis cells, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Welkos S,Cote CK,Hahn U,Shastak O,Jedermann J,Bozue J,Jung G,Ruchala P,Pratikhya P,Tang T,Lehrer RI,Beyer W

更新日期：2011-09-01 00:00:00

abstract：:The indinavir dosage regimen currently used for human immunodeficiency virus (HIV)-infected children is not based on pharmacokinetic data obtained in the target patient population. The purpose of our study was to characterize indinavir pharmacokinetics and pharmacodynamics in HIV-infected children. Eleven children (ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Vigano' A,Sala N,Vella S,Bassetti M,Bassetti D,Principi N

更新日期：2000-03-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:Piperaquine (PQ) is an important partner drug in antimalarial combination treatments, but the long half-life of PQ raises concerns about drug resistance. Our aim was to investigate the extended antimalarial effect of PQ in a study of drug efficacy, reinoculation outcomes, and parasite viability after the administratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Ilett KF,Page-Sharp M,Jago JD,Batty KT

更新日期：2009-07-01 00:00:00

abstract：:Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericid...

journal_title：Antimicrobial agents and chemotherapy

authors： Klepser ME,Banevicius MA,Quintiliani R,Nightingale CH

更新日期：1996-08-01 00:00:00

abstract：:The increasing incidence and severity of infection by Clostridium difficile have stimulated attempts to develop new antimicrobial therapies. We report here the relative abilities of two antibiotics (metronidazole and vancomycin) in current use for treating C. difficile infection and of a third antimicrobial, surotomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bouillaut L,McBride S,Sorg JA,Schmidt DJ,Suarez JM,Tzipori S,Mascio C,Chesnel L,Sonenshein AL

更新日期：2015-07-01 00:00:00

abstract：:Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

更新日期：2019-02-26 00:00:00

abstract：:The in vitro activity of BMS-207147 against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method. Geometric mean MICs (in microg/ml) were as follows: 1.71 for BMS-207147, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore CB,Walls CM,Denning DW

更新日期：2000-02-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2003-09-01 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:The pharmacodynamics of gemifloxacin against Streptococcus pneumoniae were investigated in a dilutional pharmacodynamic model of infection. Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every...

journal_title：Antimicrobial agents and chemotherapy

authors： MacGowan AP,Rogers CA,Holt HA,Wootton M,Bowker KE

更新日期：2001-10-01 00:00:00

abstract：:Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (defA) is not. Actin...

journal_title：Antimicrobial agents and chemotherapy

authors： Margolis P,Hackbarth C,Lopez S,Maniar M,Wang W,Yuan Z,White R,Trias J

更新日期：2001-09-01 00:00:00

abstract：:A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitzgibbon JE,John JF,Delucia JL,Dubin DT

更新日期：1998-08-01 00:00:00

abstract：:T-8581 is a new water-soluble triazole antifungal agent. The geometric mean IC80s (GM-IC80S; where the IC80 is the lowest drug concentration which reduced the optical density at 630 nm by 80% compared with the optical density at 630 nm of the drug-free control) for Candida albicans were as follows: T-8581, 0.218 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Shimizu K,Araki H,Fujimaki K,Nishida N,Hori R,Annen N,Yamamoto S,Hayakawa H,Imaizumi H,Watanbe Y,Narita H

更新日期：1997-01-01 00:00:00

abstract：:The creation of new chemotherapeutic regimens that permit shortening the duration of treatment is a major priority for antituberculosis drug development. In this study, we used the murine model of experimental tuberculosis therapy to determine whether incorporation of the investigational new nitroimidazopyran PA-824 i...

journal_title：Antimicrobial agents and chemotherapy

authors： Nuermberger E,Rosenthal I,Tyagi S,Williams KN,Almeida D,Peloquin CA,Bishai WR,Grosset JH

更新日期：2006-08-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00

abstract：:An indirect mouse model was utilized to evaluate the antiviral activity of several compounds against Venezuelan equine encephalomyelitis (VEE) virus infection in mice. Mice were given various dosages of lysine-stabilized polyriboinosinic acid-polyribocytidylic acid, a tilorone analogue, kethoxal, or mepacrine before a...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuehne RW,Pannier WL,Stephen EL

更新日期：1977-04-01 00:00:00

abstract：:Kingella kingae is the major pathogen causing osteoarticular infections (OAI) in young children in numerous countries. Plasmid-borne TEM-1 penicillinase production has been sporadically detected in a few countries but not in continental Europe, despite a high prevalence of K. kingae infections. We describe here for th...

journal_title：Antimicrobial agents and chemotherapy

authors： Basmaci R,Bidet P,Berçot B,Jost C,Kwon T,Gaumetou E,Bonacorsi S

更新日期：2014-10-01 00:00:00

abstract：:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinf...

journal_title：Antimicrobial agents and chemotherapy

authors： Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

更新日期：2015-05-01 00:00:00

abstract：:Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Mohr JF 3rd,Ostrosky-Zeichner L,Wainright DJ,Parks DH,Hollenbeck TC,Ericsson CD

更新日期：2008-05-01 00:00:00

abstract：:A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T2...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao D,Wu R,Dong S,Wang F,Ju C,Yu S,Xu S,Fang H,Yu Y

更新日期：2020-09-21 00:00:00