Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans.


:Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study evaluated the relationship between in vitro tPMP-1 susceptibility (tPMP-1s) or resistance (tPMP-1r) and efficacy of fluconazole (FLU) therapy of IE due to C. albicans. Candida IE was established in rabbits with either tPMP-1s or tPMP-1r strains. Treatment groups received FLU (100 mg/kg/day) intraperitoneally for 7 or 14 days; control animals received no therapy. At these time points, cardiac vegetations, kidneys, and spleens were quantitatively cultured to assess fungal burden. At both 7 and 14 days and in all target tissues, the extent of candidal clearance by FLU was greater in animals infected with the tPMP-1s strain than in those infected with the tPMP-1r strain. These differences were statistically significant in the spleen and kidney. Corroborating these in vivo data, FLU (a candidastatic agent), in combination with tPMP-1, exerted an enhanced fungicidal effect in vitro against tPMP-1s and tPMP-1r C. albicans, with the extent of this effect greatest against the tPMP-1s strain. Collectively, these results support the concept that tPMP-1 susceptibility contributes to the net efficacy of FLU against C. albicans IE in vivo, particularly in tissues in which platelets and tPMP-1 likely play significant roles in host defense.


Yeaman MR,Cheng D,Desai B,Kupferwasser LI,Xiong YQ,Gank KD,Edwards JE Jr,Bayer AS




Has Abstract


2004-08-01 00:00:00














  • Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection.

    abstract::Isoprinosine has been reported to decrease progression to AIDS, primarily by preventing Pneumocystis carinii pneumonia (PCP), in human immunodeficiency virus-infected patients, but the mechanism of action is unknown. para-Acetamidobenzoic acid (PAcBA), one component of isoprinosine, is structurally related to para-ami...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kovacs JA,Powell F,Voeller D,Allegra CJ

    更新日期:1993-06-01 00:00:00

  • Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis.

    abstract::The susceptibility of 53 clinical isolates of Bacteroides fragilis to cephamycins was examined. Judging from the MICs for 50% of the strains tested, moxalactam was the most active, however, judging from the MICs for 90% of the strains tested, cefbuperazone was more effective than moxalactam. A correlation was observed...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yotsuji A,Minami S,Kakizawa H,Yasuda T,Takai A,Saikawa I,Inoue M,Mitsuhashi S

    更新日期:1985-12-01 00:00:00

  • UK31214, a new aminoglycoside and derivative of kanamycin B.

    abstract::The in vitro activity of UK31214, a kanamycin B derivative, was studied against 250 recent isolates and compared with other aminoglycosides. Against the Enterobacteriaceae (with the exception of Proteus mirabilis and Providencia stuartii) UK31214 and amikacin had similar degrees of activity (mode minimum inhibitory co...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wise R,Andrews JM,Bedford KA

    更新日期:1980-03-01 00:00:00

  • Effect of Surotomycin, a Novel Cyclic Lipopeptide Antibiotic, on Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice.

    abstract::Surotomycin (formerly called CB-183,315) is a novel, orally administered cyclic lipopeptide antibacterial in development for the treatment of Clostridium difficile infection (CDI) that has potent activity against vancomycin-resistant enterococci (VRE) but limited activity against Gram-negative bacilli, including Bacte...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Deshpande A,Hurless K,Cadnum JL,Chesnel L,Gao L,Chan L,Kundrapu S,Polinkovsky A,Donskey CJ

    更新日期:2016-05-23 00:00:00

  • In vitro study of sequential fluconazole and caspofungin treatment against Candida albicans biofilms.

    abstract::Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular st...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sarkar S,Uppuluri P,Pierce CG,Lopez-Ribot JL

    更新日期:2014-01-01 00:00:00

  • Cefaclor: in vitro spectrum of activity and beta-lactamase stability.

    abstract::The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Neu HC,Fu KP

    更新日期:1978-04-01 00:00:00

  • Pharmacokinetics of minocycline in renal failure.

    abstract::The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Welling PG,Shaw WR,Uman SJ,Tse FL,Craig WA

    更新日期:1975-11-01 00:00:00

  • In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.

    abstract::9-[2-(Boranophosphonomethoxy)ethyl]adenine diphosphate (BH(3)-PMEApp) and (R)-9-[2-(boranophosphonomethoxy)propyl]adenine diphosphate (BH(3)-PMPApp), described here, represent the first nucleoside phosphonates modified on their alpha-phosphates that act as efficient substrates for the human immunodeficiency virus type...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Frangeul A,Barral K,Alvarez K,Canard B

    更新日期:2007-09-01 00:00:00

  • Antimicrobial activities of mefloquine and a series of related compounds.

    abstract::Mefloquine was found to have bactericidal activity against methicillin- and fluoroquinolone-susceptible and -resistant strains of Staphylococcus aureus and Staphylococcus epidermidis and gentamicin- and vancomycin-resistant strains of Enterococcus faecalis and Enterococcus faecium. The MICs were 16 microg/ml, and the ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kunin CM,Ellis WY

    更新日期:2000-04-01 00:00:00

  • Development and Characterization of Monoolein-Based Liposomes of Carvacrol, Cinnamaldehyde, Citral or Thymol with anti-Candida Activities.

    abstract::There is an increasing need for novel drugs and new strategies for the therapy of invasive candidiasis. This study aimed to develop and characterize liposome-based nanoparticles of carvacrol, cinnamaldehyde, citral or thymol with anti-Candida activities. Dioctadecyldimethylammonium bromide- and monoolein-based liposom...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Miranda-Cadena K,Dias M,Costa-Barbosa A,Collins T,Marcos-Arias C,Eraso E,Pais C,Quindós G,Sampaio P

    更新日期:2021-01-19 00:00:00

  • In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae.

    abstract::The in vitro activity of tebipenem (TBM), a new oral carbapenem antibiotic, against Streptococcus pneumoniae clinical isolates (n = 202) was compared with those of 15 reference agents. The isolates were classified into five genotypic classes after PCR identification of abnormal pbp1a, pbp2x, and pbp2b genes: (i) penic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kobayashi R,Konomi M,Hasegawa K,Morozumi M,Sunakawa K,Ubukata K

    更新日期:2005-03-01 00:00:00

  • Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.

    abstract::GS-9148 is an investigational phosphonate nucleotide analogue inhibitor of reverse transcriptase (RT) (NtRTI) of human immunodeficiency virus type 1 (HIV-1). This compound is an adenosine derivative with a 2',3'-dihydrofuran ring structure that contains a 2'-fluoro group. The resistance profile of GS-9148 is unique in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Scarth BJ,White KL,Chen JM,Lansdon EB,Swaminathan S,Miller MD,Götte M

    更新日期:2011-06-01 00:00:00

  • CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.

    abstract::We designed, synthesized, and characterized a novel nucleoside analog, (1S,3S,5S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-5-hydroxy-1-(hydroxymethyl)-2-methylene-cyclopentanecarbonitrile, or 4'-cyano-methylenecarbocyclic-2'-deoxyguanosine (CMCdG), and evaluated its anti-hepatitis B virus (anti-HBV) activity, safet...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Higashi-Kuwata N,Hayashi S,Das D,Kohgo S,Murakami S,Hattori SI,Imoto S,Venzon DJ,Singh K,Sarafianos SG,Tanaka Y,Mitsuya H

    更新日期:2019-03-27 00:00:00

  • Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents.

    abstract::The bioavailabilities of orally administered drugs depend to a great extent on their capability of being transported across the intestinal mucosa. In an attempt to develop an in vitro model for studying the intestinal transport of drugs, we used an intestinal epithelial cell line (Caco 2) derived from a human colon ad...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ranaldi G,Islam K,Sambuy Y

    更新日期:1992-07-01 00:00:00

  • Roles of gyrA mutations in resistance of clinical isolates and in vitro mutants of Bacteroides fragilis to the new fluoroquinolone trovafloxacin.

    abstract::We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B. fragilis. The two first-step mutants selected on ciprofloxacin (CIP) were devoid of gyrA mutations, whereas two of the three...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bachoual R,Dubreuil L,Soussy CJ,Tankovic J

    更新日期:2000-07-01 00:00:00

  • Inhibition of bacteriophage lambda, T1, and T7 development by R plasmids of the H incompatibility group.

    abstract::R plasmids from chloramphenicol-resistant salmonella from Ontario are shown to belong to the H(2) incompatibility subgroup and to mediate a broad-spectrum, phage inhibition function. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Taylor DE,Grant RB

    更新日期:1976-10-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.

    abstract::Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Feldman WE,Zweighaft T

    更新日期:1979-02-01 00:00:00

  • Effectiveness of antimicrobial treatment against Borrelia burgdorferi infection in mice.

    abstract::Although antimicrobial agents are effective therapy for early Lyme disease, optimal treatment schedules have not been conclusively established. The efficacy of various dosages of eight antibiotics used for borreliosis treatment was evaluated for C3H/HeNCrIBR mice, which reproducibly develop persistent infection, arthr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Moody KD,Adams RL,Barthold SW

    更新日期:1994-07-01 00:00:00

  • An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment.

    abstract::Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

    更新日期:2020-04-21 00:00:00

  • A cell-based strategy to assess intrinsic inhibition efficiencies of HIV-1 reverse transcriptase inhibitors.

    abstract::During HIV-1 reverse transcription, there are increasing opportunities for nucleos(t)ide (NRTI) or nonnucleoside (NNRTI) reverse transcriptase (RT) inhibitors to stop elongation of the nascent viral DNA (vDNA). In addition, RT inhibitors appear to influence the kinetics of vDNA synthesis differently. While cell-free k...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Abram ME,Tsiang M,White KL,Callebaut C,Miller MD

    更新日期:2015-02-01 00:00:00

  • Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus.

    abstract::Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cheng M,Huang JX,Ramu S,Butler MS,Cooper MA

    更新日期:2014-11-01 00:00:00

  • Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists.

    abstract::How HIV-1 resistant to small-molecule CCR5 antagonists uses the coreceptor for entry has been studied in a limited number of isolates. We characterized dependence on the N terminus (NT) and the second extracellular loop (ECL2) of CCR5 of three vicriviroc (VCV)-resistant clinical isolates broadly cross-resistant to oth...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Henrich TJ,Lewine NR,Lee SH,Rao SS,Berro R,Gulick RM,Moore JP,Tsibris AM,Kuritzkes DR

    更新日期:2012-04-01 00:00:00

  • Antibiotic resistance and serotypes of 100 Streptococcus pneumoniae strains isolated in a children's hospital in Barcelona, Spain.

    abstract::A total of 100 Streptococcus pneumoniae strains with various penicillin G susceptibilities, isolated in Barcelona, Spain, from different pediatric sources during 1983 and the first 4 months of 1984, were tested for susceptibility to tetracycline, chloramphenicol, erythromycin, clindamycin, vancomycin, and rifampin. Th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Latorre C,Juncosa T,Sanfeliu I

    更新日期:1985-08-01 00:00:00

  • Enzymatic detachment of Staphylococcus epidermidis biofilms.

    abstract::The gram-positive bacterium Staphylococcus epidermidis is the most common cause of infections associated with catheters and other indwelling medical devices. S. epidermidis produces an extracellular slime that enables it to form adherent biofilms on plastic surfaces. We found that a biofilm-releasing enzyme produced b...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kaplan JB,Ragunath C,Velliyagounder K,Fine DH,Ramasubbu N

    更新日期:2004-07-01 00:00:00

  • Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model.

    abstract::The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

    更新日期:1989-08-01 00:00:00

  • Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.

    abstract::We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Spreghini E,Orlando F,Santinelli A,Pisa E,Loretelli C,Manso E,Milici ME,Scalise G,Barchiesi F

    更新日期:2009-09-01 00:00:00

  • Comparison of Septic Shock Due to Multidrug-Resistant Acinetobacter baumannii or Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Intensive Care Unit Patients.

    abstract::A significant cause of mortality in the intensive care unit (ICU) is multidrug-resistant (MDR) Gram-negative bacteria, such as MDR Acinetobacter baumannii (MDR-AB) and Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp). The aim of the present study was to compare the clinical features, therapy, and o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Russo A,Giuliano S,Ceccarelli G,Alessandri F,Giordano A,Brunetti G,Venditti M

    更新日期:2018-05-25 00:00:00

  • Sustained delivery of commensal bacteria from pod-intravaginal rings.

    abstract::Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

    更新日期:2014-01-01 00:00:00

  • Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.

    abstract::Expression of high-level beta-lactam resistance is known to be thermosensitive in many methicillin-resistant Staphylococcus aureus (MRSA) strains, including strain COL, in which the high methicillin MIC for cultures grown at 37 degrees C (800 microg/ml) was reduced to 12 microg/ml at 42 degrees C. COL grew faster at 4...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sieradzki K,Chung M,Tomasz A

    更新日期:2008-02-01 00:00:00

  • The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity.

    abstract::We found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Li M,Mislak AC,Foli Y,Agbosu E,Bose V,Bhandari S,Szymanski MR,Shumate CK,Yin YW,Anderson KS,Paintsil E

    更新日期:2016-08-22 00:00:00