Mode of action of lividomycin on protein synthesis in Escherichia coli.

abstract：:VT-1161 and VT-1598 are promising investigational tetrazole antifungals that have shown in vitro and in vivo activity against Candida and other fungi. Candida glabrata is a problematic opportunistic pathogen that is associated with high mortality in invasive infection, as well as both intrinsic and rapidly acquired an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishimoto AT,Whaley SG,Wiederhold NP,Zhang Q,Yates CM,Hoekstra WJ,Schotzinger RJ,Garvey EP,Rogers PD

更新日期：2019-09-23 00:00:00

abstract：:We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necro...

journal_title：Antimicrobial agents and chemotherapy

authors： Su F,Xue Y,Wang Y,Zhang L,Chen W,Hu S

更新日期：2015-09-01 00:00:00

abstract：:The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Novotna GB,Kwun MJ,Hong HJ

更新日期：2015-12-28 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00

abstract：:Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, express a single polar flagellum powered by sodium motive force and require motility to colonize and spread along the small intestine. In a previous study, we described a high-throughput assay for screening for sm...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Zhang L,Silva AJ,Benitez JA

更新日期：2013-08-01 00:00:00

abstract：:Guanylhydrazones are cationic heteroaromatic drugs similar to the diamidines which are effective in the treatment of African trypanosomiasis and pneumocystosis. On the basis of their antitrypanosomal activity, different guanylhydrazones were selected for evaluation in a rat model of Pneumocystis carinii pneumonia. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Walzer PD,Foy J,Runck J,Steele P,White M,Klein RS,Otter BA,Sundberg RJ

更新日期：1994-11-01 00:00:00

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

更新日期：2015-09-01 00:00:00

abstract：:The in vitro antifungal activities of two N-aminoacyl derivatives of amphotericin B methyl ester (AME) were compared by tube dilution with those of amphotericin B and AME, using 60 isolates representing 10 yeast species. A total of 70% of the strains were inhibited by concentrations of the N-aminoacyl AME derivatives ...

journal_title：Antimicrobial agents and chemotherapy

authors： Oblack DL,Hewitt WL,Martin WJ

更新日期：1981-01-01 00:00:00

abstract：:High-dose clindamycin (CLDM) and benzylpenicillin (PCG) are the recommended chemotherapeutic remedies for toxic shock-like syndrome caused by group A streptococci. One reason for this is that it has been shown that CLDM suppresses the expression of some exoproteins, e.g., SpeB, SpeA, and streptolysin O (Slo). We analy...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka M,Hasegawa T,Okamoto A,Torii K,Ohta M

更新日期：2005-01-01 00:00:00

abstract：:The activities of mecillinam and ampicillin, alone and in combination, were evaluated in mice infected with the LT-2 strain of Salmonella typhimurium. The minimal inhibitory concentrations of mecillinam and ampicillin for this strain were, respectively, 6.2 and 0.4 microgram/ml of culture medium. In vitro synergy was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler T,Shuster CW,Dixon P

更新日期：1981-02-01 00:00:00

abstract：:We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

更新日期：2020-12-14 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a type 2-preferential but not a type 2-specific antiviral effect. Utilizing a microtiter assay with BHK-21 cells, we found ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teh CZ,Sacks SL

更新日期：1983-05-01 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:The in vivo efficacy of ciprofloxacin or pefloxacin alone or in combination with fosfomycin was evaluated in experimental aortic valve endocarditis induced in 133 rabbits by a multidrug-susceptible or multidrug-resistant strain of Pseudomonas aeruginosa. Therapy was initiated early (12 h after infection), when bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Potel G,Caillon J,Stephant G,Jehl F,Bugnon D,Le Conte P,Baron D,Drugeon H

更新日期：1995-02-01 00:00:00

abstract：:Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is associated with amino acid substitutions in the cyp51A gene. To obtain insight into azole resistance mutations, the cyp51A gene of 130 resistant and 76 susceptible A. fumigatus isolates was sequenced. Out of 130 azole-resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Snelders E,Karawajczyk A,Schaftenaar G,Verweij PE,Melchers WJ

更新日期：2010-06-01 00:00:00

abstract：:A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employ...

journal_title：Antimicrobial agents and chemotherapy

authors： Upcroft JA,Upcroft P

更新日期：2001-06-01 00:00:00

abstract：:The efficacies of ciprofloxacin and ampicillin against Listeria monocytogenes in an immunosuppressed mouse model of listeriosis were compared. Immunosuppression was achieved by administration of 2.5 mg of hydrocortisone acetate daily. Both ciprofloxacin and ampicillin were effective in reducing the number of viable L....

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Mattie H,Sekh BR,van Strijen E,van Furth R

更新日期：1992-11-01 00:00:00

abstract：:Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutt M,Khuller GK

更新日期：2001-01-01 00:00:00

abstract：:The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between th...

journal_title：Antimicrobial agents and chemotherapy

authors： Salfinger M,Heifets LB

更新日期：1988-07-01 00:00:00

abstract：:Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mitchell KF,Taff HT,Cuevas MA,Reinicke EL,Sanchez H,Andes DR

更新日期：2013-04-01 00:00:00

abstract：:Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumig...

journal_title：Antimicrobial agents and chemotherapy

authors： Denning DW,Venkateswarlu K,Oakley KL,Anderson MJ,Manning NJ,Stevens DA,Warnock DW,Kelly SL

更新日期：1997-06-01 00:00:00

abstract：:A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Cuchural GJ Jr,Jacobus NV,Gorbach SL,Aldridge K,Cleary T,Finegold SM,Hill G,Iannini P,O'Keefe JP

更新日期：1985-11-01 00:00:00

abstract：:The pharmacokinetics of the macrolide roxithromycin (RU 28965) were studied during and after administration of 150 mg every 12 h for 3 days (five doses) in six volunteers. The concentrations in serum, blister fluid, and urine were measured. Mean levels in serum taken at 1.5 h after the morning dose increased from 4.4 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Kirkpatrick B,Ashby J,Andrews JM

更新日期：1987-07-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:A group H1 R factor encoding resistance to chloramphenicol, streptomycin, sulfonamide, and tetracycline was transferred into Salmonella typhimurium LT-2. The virulence of LT-2 for mice, as assessed by intraperitoneal 50% lethal dose and the number of organisms in the spleen, was not affected by the R factor. On the ot...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler T,Shuster CW,Franco A

更新日期：1979-03-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00

abstract：:Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

journal_title：Antimicrobial agents and chemotherapy

authors： Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

更新日期：2020-04-21 00:00:00