Itraconazole resistance in Aspergillus fumigatus.

abstract：:Amphotericin B lipid complex for injection (ABLC) is a suspension of amphotericin B complexed with the lipids L-alpha-dimyristoylphosphatidylcholine (DMPC) and L-alpha-dimyristoylphosphatidylglycerol. ABLC is less toxic than amphotericin B deoxycholate (AmB-d), while it maintains the antifungal activity of AmB-d. Acti...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson CE,Perkins WR,Roberts P,Ahmad I,Stevens R,Stevens DA,Janoff AS

更新日期：1998-04-01 00:00:00

abstract：:Itraconazole is used for the prevention and treatment of infections caused by Aspergillus fumigatus. An understanding of the pharmacodynamics of itraconazole against wild-type and triazole-resistant strains provides a basis for innovative therapeutic strategies for treatment of infections. An in vitro model of the hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Nakeeb Z,Sudan A,Jeans AR,Gregson L,Goodwin J,Warn PA,Felton TW,Howard SJ,Hope WW

更新日期：2012-08-01 00:00:00

abstract：:Encephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, both in vitro and in cells. AG1478 impaired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dorobantu CM,Harak C,Klein R,van der Linden L,Strating JR,van der Schaar HM,Lohmann V,van Kuppeveld FJ

更新日期：2016-09-23 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:Lipids in fresh human milk do not inactivate viruses but become antiviral after storage of the milk for a few days at 4 or 23 degrees C. The appearance of antiviral activity depends on active milk lipases and correlates with the release of free fatty acids in the milk. A number of fatty acids which are normal componen...

journal_title：Antimicrobial agents and chemotherapy

authors： Thormar H,Isaacs CE,Brown HR,Barshatzky MR,Pessolano T

更新日期：1987-01-01 00:00:00

abstract：:The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than a...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott NW,Harwood CR

更新日期：1981-04-01 00:00:00

abstract：:Sch 21420 is a new aminoglycoside synthesized from gentamicin B. Susceptibility tests with Sch 21420, amikacin, gentamicin, netilmicin, sisomicin, and tobramycin were performed on a variety of bacterial species including 44 with known mechanisms of resistance to aminoglycosides. Sch 21420 and amikacin had similar effe...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Barry AL,Jones RN,Baker CN,Badal RE,Packer RR

更新日期：1980-08-01 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:Prolonged antimicrobial therapy is recommended for methicillin-susceptible Staphylococcus aureus (MSSA) bone and joint infections (BJI), but its safety profile and risk factors for severe adverse events (SAE) in clinical practice are unknown. We addressed these issues in a retrospective cohort study (2001 to 2011) ana...

journal_title：Antimicrobial agents and chemotherapy

authors： Valour F,Karsenty J,Bouaziz A,Ader F,Tod M,Lustig S,Laurent F,Ecochard R,Chidiac C,Ferry T,Lyon BJI Study Group.

更新日期：2014-01-01 00:00:00

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococca...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MS,Chai Y,Britigan BE,McKenna W,Adams J,Svendsen T,Bean K,Hassett DJ,Sparling PF

更新日期：1987-10-01 00:00:00

abstract：:To investigate the effects of posaconazole (POS) and amphotericin B (AMB) combination therapy in cryptococcal infection, we established an experimental model of systemic cryptococcosis in CD1 mice by intravenous injection of three distinct clinical isolates of Cryptococcus neoformans. Therapy was started 24 h after th...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Schimizzi AM,Maracci M,Giannini D,Carle F,Scalise G

更新日期：2004-09-01 00:00:00

abstract：:Within wounds, microorganisms predominantly exist as biofilms. Biofilms are associated with chronic infections and represent a tremendous clinical challenge. As antibiotics are often ineffective against biofilms, use of dispersal agents as adjunctive, topical therapies for the treatment of wound infections involving b...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanchez CJ Jr,Akers KS,Romano DR,Woodbury RL,Hardy SK,Murray CK,Wenke JC

更新日期：2014-08-01 00:00:00

abstract：:Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome. Sprague-Dawley male rats were used to investigate the pharmacokinetics and bioavailability of carbovir. Six rats received car...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeom YH,Remmel RP,Huang SH,Hua M,Vince R,Zimmerman CL

更新日期：1989-02-01 00:00:00

abstract：:Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone. In an open crossover study with two phases, 12 healthy volunteers took a single oral dose of 10 mg of immediate-release oxycodone with or without thrice-daily 85-mg miconazole oral gel treatment. The plasma concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： Grönlund J,Saari TI,Hagelberg N,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2011-03-01 00:00:00

abstract：:Various parameters were examined for their effects on interferon production with human fibroblast cells (FS-4) grown on microcarriers, using a superinduction procedure. Optimal concentrations of cycloheximide and actinomycin D during induction were 10 micrograms/ml, respectively. Cells required 5 to 6 h of exposure to...

journal_title：Antimicrobial agents and chemotherapy

authors： Giard DJ,Fleischaker RJ

更新日期：1980-07-01 00:00:00

abstract：:The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. P...

journal_title：Antimicrobial agents and chemotherapy

authors： Barbhaiya RH,Gerber AU,Craig WA,Welling PG

更新日期：1982-03-01 00:00:00

abstract：:Tilorone hydrochloride characteristically induces an unusually delayed and prolonged interferon response not commonly associated with other synthetic inducers. Maximum circulating interferon levels of 8,000 to 10,000 units/ml were detected 12 hr postinoculation and persisted for up to 30 hr after administration of til...

journal_title：Antimicrobial agents and chemotherapy

authors： Stringfellow DA,Glasgow LA

更新日期：1972-08-01 00:00:00

abstract：:Heteroresistant (methicillin-resistant) and nonheteroresistant strains of Staphylococcus aureus were tested for their susceptibility to penicillinase-resistant penicillins at incubation temperatures of 37, 35, and 30 C. Susceptibilities were determined by agar dilution and by the standard Kirby-Bauer agar diffusion te...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Caruthers JQ,Baker CN

更新日期：1973-09-01 00:00:00

abstract：:A practical preclinical model for the hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors has been developed. Indinavir and atazanavir produced significant hyperbilirubinemia, whereas amprenavir, the negative control, was indistinguishable from the ritonavir booster dose. This model was use...

journal_title：Antimicrobial agents and chemotherapy

authors： Kempf DJ,Waring JF,Morfitt DC,Werner P,Ebert B,Mitten M,Nguyen B,Randolph JT,DeGoey DA,Klein LL,Marsh K

更新日期：2006-02-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are resistant to most antibiotics, making CRE infections extremely difficult to treat with available agents. Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) are predominant carbapenemases in CRE in the United States. Nacubactam is a bridged diazabicyclooctane (DBO) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes MD,Taracila MA,Good CE,Bajaksouzian S,Rojas LJ,van Duin D,Kreiswirth BN,Jacobs MR,Haldimann A,Papp-Wallace KM,Bonomo RA

更新日期：2019-07-25 00:00:00

abstract：:The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Fothergill AW,Arzeni D,Greganti G,Giannini D,Rinaldi MG,Scalise G

更新日期：2005-06-01 00:00:00

abstract：:Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Prunier AL,Malbruny B,Tandé D,Picard B,Leclercq R

更新日期：2002-09-01 00:00:00

abstract：:Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 microg/ml). The MIC50 of rifabutin was 0.008 microg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exc...

journal_title：Antimicrobial agents and chemotherapy

authors： Heep M,Beck D,Bayerdörffer E,Lehn N

更新日期：1999-06-01 00:00:00

abstract：:Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli, the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin. We report here that this hypersusceptibility can be observed in TolC-deficient cells and is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrushenko ZM,Zhao H,Zgurskaya HI,Rybenkov VV

更新日期：2016-04-22 00:00:00

abstract：:Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Coleman VR,Wilkie J,Levinson WE,Stevens T,Jawetz E

更新日期：1973-09-01 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00