Practical preclinical model for assessing the potential for unconjugated hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors.

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:We describe a primary high-throughput screen that uses the reporter strain Bacillus subtilis BAU-102 to identify antibiotics that induce autolysis. The screen measures autolysis in terms of the incipient release of recombinant Escherichia coli beta-galactosidase (beta-Gal) from the periplasmic space of B. subtilis owi...

journal_title：Antimicrobial agents and chemotherapy

authors： Falk SP,Noah JW,Weisblum B

更新日期：2010-09-01 00:00:00

abstract：:Acyclovir [9-(2-hydroxyethoxymethyl)guanine] (ACV), a potent antiviral compound, was phosphorylated to the same extent by extracts from untreated and iododeoxyuridine-treated Epstein-Barr virus-containing latent D98/HR-1 somatic hybrid cells. ATP was the preferred phosphate donor over other nucleoside triphosphates. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Datta AK,Pagano JS

更新日期：1983-07-01 00:00:00

abstract：:Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutt M,Khuller GK

更新日期：2001-01-01 00:00:00

abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

更新日期：2019-10-22 00:00:00

abstract：:The purpose of this investigation was to assess the influence that treatment with antacid and ranitidine had on the pharmacokinetics of oral cefetamet pivoxil in 18 healthy male volunteers. Each subject received, in an open-labeled, randomized, three-way crossover design, a single oral dose of 1,000 mg (two tablets) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Blouin RA,Kneer J,Ambros RJ,Stoeckel K

更新日期：1990-09-01 00:00:00

abstract：:Stenotrophomonas maltophilia is an emerging nosocomial pathogen that displays high-level intrinsic resistance to a variety of structurally unrelated antimicrobial agents. Efflux mechanisms are known to contribute to acquired multidrug resistance in this organism, and indeed, one such multidrug efflux system, SmeDEF, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang L,Li XZ,Poole K

更新日期：2001-12-01 00:00:00

abstract：:MIC methodology was used to test the antibacterial activity of XRP 2868, a new oral combination of two semisynthetic streptogramins, RPR 132552A and RPR 202868, compared to activities of other antibacterial agents against pneumococci, Haemophilus influenzae, and Haemophilus parainfluenzae. For 261 pneumococci, XRP 286...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Kelly LM,Lin G,Bryskier A,Couturier C,Jacobs MR,Appelbaum PC

更新日期：2003-10-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:Exogenous NAD, nicotinamide mononucleotide, or nicotinamide riboside is required for the growth of Haemophilus influenzae. These compounds have been defined as the V-factor growth requirement. We have previously shown that the internalization of nicotinamide riboside is energy dependent and carrier mediated with satur...

journal_title：Antimicrobial agents and chemotherapy

authors： Godek CP,Cynamon MH

更新日期：1990-08-01 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson JM,Prati F,Bethel CR,Bonomo RA

更新日期：2007-04-01 00:00:00

abstract：:We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantón E,Pemán J,Valentín A,Espinel-Ingroff A,Gobernado M

更新日期：2009-07-01 00:00:00

abstract：:Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vignaroli C,Biavasco F,Varaldo PE

更新日期：2006-07-01 00:00:00

abstract：:The physicochemical constants and some structural parameters (topological, steric, and electronic) of eight third-generation monofluorate quinolones (six uncommercialized and two used clinically [ciprofloxacin and enrofloxacin]) were determined: pKa, intrinsic solubility (S0), chromatographic capacity factor, partitio...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano E,Calpena AC,Garrigues TM,Freixas J,Domenech J,Moreno J

更新日期：1997-09-01 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown that 1843U89, even without polyglutamylation, is a potent folate-based inhibitor of purified malarial parasite thymidylat...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang L,Lee PC,White J,Rathod PK

更新日期：2000-04-01 00:00:00

abstract：:Rezafungin is a new long-acting echinocandin currently in phase 3 development. Epidemiological cutoff values are necessary for breakpoint setting but have not been established due to unexplained interlaboratory MIC variations observed in a prior multicenter study. Here we investigated if the choice of microtiter plate...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Jørgensen KM,Hare RK,Cuenca-Estrella M,Zaragoza O

更新日期：2019-08-23 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt HJ,Bernard EM,Häuser M,Armstrong D

更新日期：1988-11-01 00:00:00

abstract：:There are several major differences between the penicillin-binding proteins (PBPs) of highly penicillin-resistant and -susceptible strains of pneumococci. The highest-molecular-size PBP 1a (98 kilodaltons [kDa]) of susceptible pneumococci is not detectable in resistant bacteria. Instead, resistant strains contain a PB...

journal_title：Antimicrobial agents and chemotherapy

authors： Hakenbeck R,Ellerbrok H,Briese T,Handwerger S,Tomasz A

更新日期：1986-10-01 00:00:00

abstract：:In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the str...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzink J,Bartlett JG

更新日期：1980-04-01 00:00:00

abstract：:Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent. For many years, the risk of disease reemergence was thought to solely be through deliberate misuse of VARV strains kept in clandestine laboratories. Howev...

journal_title：Antimicrobial agents and chemotherapy

authors： Delaune D,Iseni F

更新日期：2020-03-24 00:00:00

abstract：:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

更新日期：1982-12-01 00:00:00

abstract：:Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([-]-beta-L-2',3'-dideoxy-3' thiacytidine) or famciclovir may select for viral mutants that are drug resistant due to point mutations in the polymerase gene. Determining whether such HBV mutants are sensitive to new antiviral agents is th...

journal_title：Antimicrobial agents and chemotherapy

authors： Chin R,Shaw T,Torresi J,Sozzi V,Trautwein C,Bock T,Manns M,Isom H,Furman P,Locarnini S

更新日期：2001-09-01 00:00:00

abstract：:Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics techniques also co...

journal_title：Antimicrobial agents and chemotherapy

authors： Vincent IM,Ehmann DE,Mills SD,Perros M,Barrett MP

更新日期：2016-03-25 00:00:00

abstract：:In concert with the development of novel beta-lactams and broad-spectrum cephalosporins, bacterially encoded beta-lactamases have evolved to accommodate the new agents. This study was designed to identify, at the sequence level, the genes responsible for the extended-spectrum-beta-lactamase (ESBL) phenotypes of Escher...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Tuckman M,Keeney D,Ruzin A,Bradford PA

更新日期：2009-02-01 00:00:00

abstract：:CL 188,624, CL 190,294, and CL 191,121 are novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems. The in vitro antibacterial activities of these THF carbapenems were evaluated and compared with those of biapenem, imipenem, and meropenem against 554 recent clinical isolates obtained from geographically dis...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Jacobus NV,Lin YI,Bitha P,Testa RT

更新日期：1999-03-01 00:00:00