Improved procedure for extracting aminoglycosides from renal cortical tissue.

abstract：:We report retrospective analysis of the clinical and antimicrobial susceptibility data of 140 Streptococcus pseudopneumoniae isolates. Strains were isolated mostly from respiratory tract samples from patients with underlying diseases. In the case of infection, pneumonia, mainly aspiration pneumonia, was the most frequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Laurens C,Michon AL,Marchandin H,Bayette J,Didelot MN,Jean-Pierre H

更新日期：2012-08-01 00:00:00

abstract：:We determined the complete nucleotide sequence of a self-transmissible IncL/M plasmid, pKOI-34, from a Klebsiella oxytoca isolate. pKOI-34 possessed the core structure of an IncL/M plasmid found in Erwinia amylovora, pEL60, with two mobile elements inserted, a transposon carrying the arsenic resistance operon and a Tn...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Kayama S,Shigemoto N,Hisatsune J,Kuwahara R,Nishio H,Yamasaki K,Wada Y,Sueda T,Ohge H,Sugai M

更新日期：2016-04-22 00:00:00

abstract：:Staphylococcal biofilms on surgical implants are the underlying cause of a lack of response to antimicrobial treatment. We investigated the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilm...

journal_title：Antimicrobial agents and chemotherapy

authors： Presterl E,Hajdu S,Lassnigg AM,Hirschl AM,Holinka J,Graninger W

更新日期：2009-08-01 00:00:00

abstract：:According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin. Among the 224 (72%) eligible patients for whom treat...

journal_title：Antimicrobial agents and chemotherapy

authors： Chauty A,Ardant MF,Adeye A,Euverte H,Guédénon A,Johnson C,Aubry J,Nuermberger E,Grosset J

更新日期：2007-11-01 00:00:00

abstract：:Antibiotic therapy is the most commonly used strategy to control pathogenic infections; however, it has contributed to the generation of antibiotic-resistant bacteria. To circumvent this emerging problem, we are searching for compounds that target bacterial virulence factors rather than their viability. Pseudomonas ae...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamazaki A,Li J,Zeng Q,Khokhani D,Hutchins WC,Yost AC,Biddle E,Toone EJ,Chen X,Yang CH

更新日期：2012-01-01 00:00:00

abstract：:The mutations in the quinolone resistance-determining region of the gyrA gene from clinical isolates of Pseudomonas aeruginosa were determined by DNA sequencing. The strains were isolated in 1989 and 1993. No mutations were detected in the clinical isolates in 1989, while five types of mutations were identified in the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yonezawa M,Takahata M,Matsubara N,Watanabe Y,Narita H

更新日期：1995-09-01 00:00:00

abstract：:Antibiotic therapy with penicillin, doxycycline, and ceftriaxone has proven to be effective for the treatment of Lyme borreliosis. In some patients, however, it was noticed that borreliae can survival in the tissues in spite of seemingly adequate therapy. For a better understanding of this phenomenon, we investigated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersten A,Poitschek C,Rauch S,Aberer E

更新日期：1995-05-01 00:00:00

abstract：:The capacity for intracellular growth is an important survival strategy for a large group of common pathogens. Helicobacter pylori, the etiological agent for gastritis and duodenal ulcer, has been shown by both in vivo and in vitro studies to have the capacity to invade epithelial cells. In vitro models are used to st...

journal_title：Antimicrobial agents and chemotherapy

authors： Hultén K,Rigo R,Gustafsson I,Engstrand L

更新日期：1996-12-01 00:00:00

abstract：:We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters w...

journal_title：Antimicrobial agents and chemotherapy

authors： Keirns J,Sawamoto T,Holum M,Buell D,Wisemandle W,Alak A

更新日期：2007-02-01 00:00:00

abstract：:Lysostaphin is an endopeptidase that kills Staphylococcus aureus, a predominant organism in catheter-related infections. Lysostaphin-coated catheters prevented catheter colonization by several strains of S. aureus, and activity was maintained for at least 4 days. Prophylactic use of lysostaphin in catheters may help p...

journal_title：Antimicrobial agents and chemotherapy

authors： Shah A,Mond J,Walsh S

更新日期：2004-07-01 00:00:00

abstract：:The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

更新日期：2015-09-01 00:00:00

abstract：:Antimicrobial liquids and foams were applied to the hands to determine their virucidal activity against rhinoviruses. Dilute solutions (1%) of iodine in ethyl alcohol or in water were most effective in causing inactivation of rhinovirus when applied immediately after viral contamination. Iodine also had a residual vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Hendley JO,Mika LA,Gwaltney JM Jr

更新日期：1978-11-01 00:00:00

abstract：:Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Borowski P,Lang M,Haag A,Schmitz H,Choe J,Chen HM,Hosmane RS

更新日期：2002-05-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00

abstract：:ICESp1116, responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, was comprehensively characterized, and its chromosomal integration site was determined. It displayed a unique mosaic organization consisting of a scaffold, related to TnGallo1 from Streptococcus gallolyticus, with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Tiberi E,Morici E,Oryasin E,Giovanetti E,Varaldo PE

更新日期：2012-12-01 00:00:00

abstract：:We studied the efficacy of new experimental antifungal drugs, which represent molecular modifications of present active agents, in a murine model of blastomycosis. Ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, Bay l 9139, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Lefler E,Brummer E,Perlman AM,Stevens DA

更新日期：1985-03-01 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

journal_title：Antimicrobial agents and chemotherapy

authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

更新日期：2017-10-24 00:00:00

abstract：:Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hatfaludi T,Al-Hasani K,Dunstone M,Boyce J,Adler B

更新日期：2008-11-01 00:00:00

abstract：:Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and devel...

journal_title：Antimicrobial agents and chemotherapy

authors： Bulitta JB,Yang JC,Yohonn L,Ly NS,Brown SV,D'Hondt RE,Jusko WJ,Forrest A,Tsuji BT

更新日期：2010-05-01 00:00:00

abstract：:We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto K,Yanagihara K,Sugahara K,Imamura Y,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Hirakata Y,Kamihira S,Kohno S

更新日期：2009-08-01 00:00:00

abstract：:Community-acquired multidrug resistant Enterobacteriaceae (MDR-Ent) infections continue to increase in the United States. In prior studies, we identified neighboring regions in Chicago, Illinois, where children have 5 to 6 times greater odds of MDR-Ent infections. To prevent community spread of MDR-Ent, we need to ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Logan LK,Zhang L,Green SJ,Dorevitch S,Arango-Argoty GA,Reme K,Garner E,Aldstadt J,Johnson-Walker YJ,Hayden MK,Weinstein RA,Pruden A

更新日期：2020-03-24 00:00:00

abstract：:Bovicin HC5, a broad-spectrum lantibiotic produced by Streptococcus bovis HC5, catalyzed the efflux of intracellular potassium from Streptococcus bovis JB1, a sensitive strain. The level of ATP also decreased, but this decline appeared to be caused by the activity of the F(1)F(0) ATPase rather than efflux per se. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantovani HC,Russell JB

更新日期：2008-06-01 00:00:00

abstract：:We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a short hairpin RNA (shRNA). To design small interfering RNAs (siRNAs) targeting this site, we evaluated the effects of siRNAs with different lengths on HIV-1 production. The potency and efficacy of these siRNAs...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarborough RJ,Adams KL,Daher A,Gatignol A

更新日期：2015-09-01 00:00:00

abstract：:The increasing use of carbapenems for treating multidrug-resistant (MDR) Gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Serine and metallo-β-lactamases (MBLs) that hydrolyze carbapenems have become prevalent and endemic in some countries...

journal_title：Antimicrobial agents and chemotherapy

authors： Bradford PA,Kazmierczak KM,Biedenbach DJ,Wise MG,Hackel M,Sahm DF

更新日期：2015-12-14 00:00:00

abstract：:A total of 636 vancomycin-resistant Enterococcus faecium (VRE) isolates that had been obtained between 1994 and 1999 from the Medical School Hospital of the University of Michigan, Ann Arbor, were tested for bacteriocin production. Two hundred seventy-seven (44%) of the strains were bacteriocinogenic; and 193 of these...

journal_title：Antimicrobial agents and chemotherapy

authors： Inoue T,Tomita H,Ike Y

更新日期：2006-04-01 00:00:00

abstract：:The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Dudley MN,Nightingale CH,Drezner AD,Low HB,Quintiliani R

更新日期：1984-09-01 00:00:00

abstract：:The substituted benzimidazole omeprazole, used for the treatment of human peptic ulcer disease, inhibits the growth of the metronidazole-resistant bovine pathogen Tritrichomonas foetus in vitro (MIC at which the growth of parasite cultures is inhibited by 50%, 22 microg/ml [63 microM]). The antitrichomonad activity ap...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutak R,Tachezy J,Kulda J,Hrdý I

更新日期：2004-06-01 00:00:00

abstract：:Avibactam is a new non-β-lactam β-lactamase inhibitor that shows promising restoration of ceftazidime activity against microorganisms producing Ambler class A extended-spectrum β-lactamases (ESBLs) and carbapenemases such as KPCs, class C β-lactamases (AmpC), and some class D enzymes. To determine optimal dosing combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berkhout J,Melchers MJ,van Mil AC,Seyedmousavi S,Lagarde CM,Schuck VJ,Nichols WW,Mouton JW

更新日期：2015-11-02 00:00:00

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00