Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery.

abstract：:A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clar...

journal_title：Antimicrobial agents and chemotherapy

authors： Debets-Ossenkopp YJ,Brinkman AB,Kuipers EJ,Vandenbroucke-Grauls CM,Kusters JG

更新日期：1998-10-01 00:00:00

abstract：:The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Swidergall M,Ernst AM,Ernst JF

更新日期：2013-08-01 00:00:00

abstract：:Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to detect the prevalen...

journal_title：Antimicrobial agents and chemotherapy

authors： Saravolatz SN,Martin H,Pawlak J,Johnson LB,Saravolatz LD

更新日期：2014-06-01 00:00:00

abstract：:We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

更新日期：1983-12-01 00:00:00

abstract：:SCE-129 [3-(4-carbamoyl-1-pyridiniomethyl)-7beta-(d-alpha-sulfophenylacetamido)-ceph-3-em-4-carboxylate monosodium salt], a new semisynthetic cephalosporin, shows potent in vitro antibacterial activities against Pseudomonas aeruginosa and some gram-positive bacteria, whereas it shows lower activity against many gram-n...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuchiya K,Kondo M,Nagatomo H

更新日期：1978-02-01 00:00:00

abstract：:The nucleotide sequence of the constitutively produced beta-lactamase (Bla) gene from Enterococcus faecalis HH22 was shown to be identical to the published sequences of three of four staphylococcal type A beta-lactamase genes; more differences were seen with the genes for staphylococcal type C and D enzymes. One hundr...

journal_title：Antimicrobial agents and chemotherapy

authors： Zscheck KK,Murray BE

更新日期：1991-09-01 00:00:00

abstract：:Toxoplasma gondii and Cryptosporidium parvum, members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium Boromycin potently inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Abenoja J,Cotto-Rosario A,O'Connor R

更新日期：2021-01-19 00:00:00

abstract：:Filibuvir and VX-222 are nonnucleoside inhibitors (NNIs) that bind to the thumb II allosteric pocket of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. Both compounds have shown significant promise in clinical trials and, therefore, it is relevant to better understand their mechanisms of inhibition. In our s...

journal_title：Antimicrobial agents and chemotherapy

authors： Yi G,Deval J,Fan B,Cai H,Soulard C,Ranjith-Kumar CT,Smith DB,Blatt L,Beigelman L,Kao CC

更新日期：2012-02-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP), are relatively low...

journal_title：Antimicrobial agents and chemotherapy

authors： Font E,Rosario O,Santana J,García H,Sommadossi JP,Rodriguez JF

更新日期：1999-12-01 00:00:00

abstract：:Amphotericin B and N-D-ornithyl amphotericin B methyl ester were compared for therapeutic efficacies against experimentally induced cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis in rabbits. Antifungal activity of the two polyenes in vitro was similar for the yeasts used in these experim...

journal_title：Antimicrobial agents and chemotherapy

authors： Perfect JR,Durack DT

更新日期：1985-12-01 00:00:00

abstract：:This study sought to characterize the impact of 3 types of variation on the Standardized Antimicrobial Administration Ratio (SAAR) utilizing local National Healthcare Safety Network (NHSN) data. SAAR and antimicrobial days per 1,000 days present (AD/1000DP) were compiled monthly for Northwestern Memorial Hospital from...

journal_title：Antimicrobial agents and chemotherapy

authors： Avedissian SN,Rhodes NJ,Liu J,Aljefri D,Postelnick MJ,Sutton SH,Zembower TR,Martin D,Pais G,Cruce CE,Scheetz MH

更新日期：2019-02-26 00:00:00

abstract：:Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Montealegre MC,Roh JH,Rae M,Davlieva MG,Singh KV,Shamoo Y,Murray BE

更新日期：2016-12-27 00:00:00

abstract：:Amoxicillin was studied in normal subjects after intravenous, oral, and intramuscular administration of 250-, 500-, and 1,000-mg doses. Serum drug levels were analyzed using a two-compartment open model, as well as area under the curve (AUC) and urinary recovery. The variations of these pharmacokinetic parameters were...

journal_title：Antimicrobial agents and chemotherapy

authors： Spyker DA,Rugloski RJ,Vann RL,O'Brien WM

更新日期：1977-01-01 00:00:00

abstract：:Mycoplasma hominis was highly susceptible to two new quinolones, with MICs for 90% of isolates tested of 0.004 micrograms/ml for WIN 57273 and 0.063 micrograms/ml for sparfloxacin, which were activities much greater than the 1 microgram/ml found for ofloxacin and tetracycline. Although Ureaplasma urealyticum was less ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Cartwright FD

更新日期：1991-07-01 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00

abstract：:A total of 91 multiply resistant bacterial strains, including Klebsiella pneumoniae (32 strains), Pseudomonas aeruginosa (16 strains), and Serratia marcescens (43 strains), were collected during hospital epidemics of nosocomial infection from 1975 to 1979. These strains were resistant to gentamicin, tobramycin, cephal...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ,Gerding DN

更新日期：1980-02-01 00:00:00

abstract：:MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-f...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ

更新日期：1997-08-01 00:00:00

abstract：:The indinavir dosage regimen currently used for human immunodeficiency virus (HIV)-infected children is not based on pharmacokinetic data obtained in the target patient population. The purpose of our study was to characterize indinavir pharmacokinetics and pharmacodynamics in HIV-infected children. Eleven children (ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Vigano' A,Sala N,Vella S,Bassetti M,Bassetti D,Principi N

更新日期：2000-03-01 00:00:00

abstract：:The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bourgault AM,Lamothe F,Hoban DJ,Dalton MT,Kibsey PC,Harding G,Smith JA,Low DE,Gilbert H

更新日期：1992-02-01 00:00:00

abstract：:Seventeen clinical isolates of group C streptococci were tested for penicillin tolerance. Sixteen of the strains showed penicillin tolerance with a 32-fold or greater difference between the minimal inhibitory concentration and the minimal bactericidal concentration. Synergism was demonstrated with a combination of pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Portnoy D,Prentis J,Richards GK

更新日期：1981-08-01 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez P,Alonso A,Martinez JL

更新日期：2002-11-01 00:00:00

abstract：:The minimal inhibitory concentrations of 45 antimicrobial agents were determined for 14 strains of Bacterium actinomycetem comitans (Actinobacillus actinomycetem-comitans). All the strains showed good susceptibility to tetracyclines and chloramphenicol, but not to lincomycins. Some strains were clearly resistant to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Höffler U,Niederau W,Pulverer G

更新日期：1980-06-01 00:00:00

abstract：:A rapid, sensitive, and specific method of analysis for mezlocillin in serum and urine by high-pressure liquid chromatography is described. A solid-phase extraction column was used to remove interfering substances from samples before chromatography. Quantitation included the use of an internal standard, nafcillin. Mez...

journal_title：Antimicrobial agents and chemotherapy

authors： Fiore D,Auger FA,Drusano GL,Dandu VR,Lesko LJ

更新日期：1984-11-01 00:00:00

abstract：:Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Zarember KA,Cruz AR,Huang CY,Gallin JI

更新日期：2009-06-01 00:00:00

abstract：:A Cedecea davisae isolate, which was intermediate or resistant to third-generation cephalosporins and carbapenems, was recovered from a urine sample. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC β-lactamase expression combined with porin deficiency accounted fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ammenouche N,Dupont H,Mammeri H

更新日期：2014-11-01 00:00:00

abstract：:The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family Enterobacteriaceae were inhibited by W...

journal_title：Antimicrobial agents and chemotherapy

authors： Sewell D,Barry A,Allen S,Fuchs P,McLaughlin J,Pfaller M

更新日期：1995-07-01 00:00:00

abstract：:Pseudomonas aeruginosa pneumonia remains a difficult therapeutic problem. Optimal doses and modes of administration of single agents often do not result in acceptable outcomes. Further, emergence of resistance occurs frequently in this setting with single-agent chemotherapy. The purpose of these experiments was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Liu W,Fikes S,Brown D,Drusano GL

更新日期：2013-06-01 00:00:00

abstract：:Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as Pseudomonas aeruginosa, Burkholderia multivorans, and Stenotrophomonas maltophilia We previously showed that argyrin B targets elongation factor G (FusA). Here, we show that argyrin B activity against P. aeruginosa PAO1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones AK,Woods AL,Takeoka KT,Shen X,Wei JR,Caughlan RE,Dean CR

更新日期：2017-03-24 00:00:00

abstract：:Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure of A. flavus to subinhibitory concentrations of VRC in vitro cau...

journal_title：Antimicrobial agents and chemotherapy

authors： Ukai Y,Kuroiwa M,Kurihara N,Naruse H,Homma T,Maki H,Naito A

更新日期：2018-10-24 00:00:00