Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.

abstract：:Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distrib...

journal_title：Antimicrobial agents and chemotherapy

authors： Pai H,Seo MR,Choi TY

更新日期：2007-01-01 00:00:00

abstract：:The comparative activities of azithromycin (AZI) and clarithromycin (CLA) against eight Mycobacterium avium complex (MAC) isolates were evaluated in the beige mouse model of disseminated infection. Mice were infected intravenously with approximately 10(7) viable MAC isolate. AZI at 100 or 200 mg/kg of body weight or C...

journal_title：Antimicrobial agents and chemotherapy

authors： Cynamon MH,Klemens SP,Grossi MA

更新日期：1994-07-01 00:00:00

abstract：:Intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) reduces malaria episodes by 20 to 59% across Africa. This protective efficacy, however, may be affected by the high frequency of malnutrition in African infants. We analyzed the impact of malnutrition as defined by anthropometry on t...

journal_title：Antimicrobial agents and chemotherapy

authors： Danquah I,Dietz E,Zanger P,Reither K,Ziniel P,Bienzle U,Mockenhaupt FP

更新日期：2009-05-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:High-throughput screening of transposon insertion libraries is a useful strategy for unveiling bacterial genes whose inactivation results in an altered susceptibility to antibiotics. A potential drawback of these studies is they are usually based on just one model antibiotic for each structural family, under the assum...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanz-García F,Alvarez-Ortega C,Olivares-Pacheco J,Blanco P,Martínez JL,Hernando-Amado S

更新日期：2019-04-25 00:00:00

abstract：:The binding of antibiotics to plasma (serum) proteins through hydrogen bonding can significantly influence the biological characteristics of these drugs. A rapid spectrophotometric assay has been developed that measures the level of free (unbound) penem antibiotic in serum ultrafiltrates. Whole human serum was adjuste...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Subashi TA,Lindner DL

更新日期：1988-02-01 00:00:00

abstract：:An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on the MIC(90) of 0.06 microg/ml for Streptococcus pyogenes reported in the literature) was shown to be achievable in a phase 1 study of 23 children with a once-daily (QD) modified-release, multiparticulate formul...

journal_title：Antimicrobial agents and chemotherapy

authors： Pichichero ME,Casey JR,Block SL,Guttendorf R,Flanner H,Markowitz D,Clausen S

更新日期：2008-07-01 00:00:00

abstract：:The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Cherrington JM,Marthas ML,Berardi CJ,Mulato AS,Spinner A,Tarara RP,Canfield DR,Telm S,Bischofberger N,Pedersen NC

更新日期：1996-11-01 00:00:00

abstract：:The most appropriate vancomycin dosing strategy in pediatric patients weighing ≥70 kg (weight based versus non-weight based) to achieve an area under the concentration-time curve (AUC) of ≥400 mg·liter/h and a trough concentration of <20 mg/liter is not known. Population pharmacokinetic analysis determined that dosing...

journal_title：Antimicrobial agents and chemotherapy

authors： Moffett BS,Ivaturi V,Morris J,Akcan Arikan A,Dutta A

更新日期：2019-03-27 00:00:00

abstract：:Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed....

journal_title：Antimicrobial agents and chemotherapy

authors： Li X,Hou Y,Yue L,Liu S,Du J,Sun S

更新日期：2015-10-01 00:00:00

abstract：:The minimal inhibiting concentrations (MIC) of ampicillin, trisulfapyrimidines, and various combinations of these drugs were determined for four clinical isolates of Nocardia asteroides on Mueller-Hinton agar. The combination of ampicillin and sulfonamides was found to be synergistic for three of the four isolates whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Orfanakis MG,Wilcox HG,Smith CB

更新日期：1972-03-01 00:00:00

abstract：:Hypermutable Pseudomonas aeruginosa strains are found with high frequency in the lungs of patients with chronic infections and are associated with high antibiotic resistance rates. The in vivo consequences of hypermutation for treatment in a mouse model of lung infection using strain PAO1 and its hypermutable derivati...

journal_title：Antimicrobial agents and chemotherapy

authors： Maciá MD,Borrell N,Segura M,Gómez C,Pérez JL,Oliver A

更新日期：2006-03-01 00:00:00

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:Polyamine levels are greatly increased in alveolar macrophages (AMs) during Pneumocystis pneumonia (PCP), leading to increased production of H(2)O(2), which causes AMs to undergo apoptosis. One of the mechanisms by which polyamine levels in AMs are elevated is enhanced uptake of exogenous polyamines. In this study, th...

journal_title：Antimicrobial agents and chemotherapy

authors： Liao CP,Phanstiel O 4th,Lasbury ME,Zhang C,Shao S,Durant PJ,Cheng BH,Lee CH

更新日期：2009-12-01 00:00:00

abstract：:This study evaluated the pulmonary disposition of eravacycline in 20 healthy adult volunteers receiving 1.0 mg of eravacycline/kg intravenously every 12 h for a total of seven doses over 4 days. Plasma samples were collected at 0, 1, 2, 4, 6, and 12 h on day 4, with each subject randomized to undergo a single bronchoa...

journal_title：Antimicrobial agents and chemotherapy

authors： Connors KP,Housman ST,Pope JS,Russomanno J,Salerno E,Shore E,Redican S,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:Grazoprevir (GZR) plus elbasvir is an approved treatment for chronic infection with hepatitis C virus (HCV) genotype 1 or 4. HCV infection complications include liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The objective of this study was to evaluate the pharmacokinetics and safety of multipl...

journal_title：Antimicrobial agents and chemotherapy

authors： Caro L,Wenning L,Guo Z,Fraser IP,Fandozzi C,Talaty J,Panebianco D,Ho M,Uemura N,Reitmann C,Angus P,Gane E,Marbury T,Smith WB,Iwamoto M,Butterton JR,Yeh WW

更新日期：2017-11-22 00:00:00

abstract：:We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 microg/ml) was compared to its transconjugants harboring qnrA1 or qnrS1...

journal_title：Antimicrobial agents and chemotherapy

authors： Allou N,Cambau E,Massias L,Chau F,Fantin B

更新日期：2009-10-01 00:00:00

abstract：:beta-Lactamase production was investigated in cultures of 25 Klebsiella pneumoniae isolates isolated at a hospital in Durban, South Africa, in 1994 and 1996. Twenty of these isolates gave ceftazidime MIC/ceftazidime plus clavulanate MIC ratios of >/=8, implying production of extended-spectrum beta-lactamases (ESBLs), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essack SY,Hall LM,Pillay DG,McFadyen ML,Livermore DM

更新日期：2001-01-01 00:00:00

abstract：:We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. Monte Carlo simulations were used to define the permissible HDCI meropenem regimens that could be saf...

journal_title：Antimicrobial agents and chemotherapy

authors： Cojutti P,Sartor A,Righi E,Scarparo C,Bassetti M,Pea F

更新日期：2017-09-22 00:00:00

abstract：:The biliary excretion profile of cefixime was studied in 10 patients provided with T-tube drainage of the common bile duct after cholecystectomy. Following a single 200-mg oral dose, the peak concentration of cefixime in bile reached 56.9 +/- 70 mg/liter, approximately 20 times as high as the peak concentration in ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Westphal JF,Jehl F,Schloegel M,Monteil H,Brogard JM

更新日期：1993-07-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:A gentamicin resistance determinant of a conjugative plasmid from Enterobacter cloacae was cloned on a 3.2-kilobase fragment in the PstI site of pBR322. Substrate profiles for eight aminoglycosides at three concentrations showed that the resistance was due to aminoglycoside-(3)-N-acetyltransferase isoenzyme II. Insert...

journal_title：Antimicrobial agents and chemotherapy

authors： Vliegenthart JS,Ketelaar-van Gaalen PA,van de Klundert JA

更新日期：1989-08-01 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

更新日期：2014-09-01 00:00:00

abstract：:Ampicillin and erythromycin were shown to act synergistically in vitro against the majority of strains of Nocardia asteroides tested. With these strains, the minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- to more than 512-fold as compared with the MIC of each antibiotic acting individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Finland M,Bach MC,Garner C,Gold O

更新日期：1974-03-01 00:00:00

abstract：:Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close relative of N. fowleri, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarink MJ,Tielens AGM,Verbon A,Sutak R,van Hellemond JJ

更新日期：2020-07-22 00:00:00

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Nephrotoxicity is the main complication of gentamicin (GM) treatment. GM induces renal damage by overproduction of reactive oxygen species and inflammation in proximal tubular cells. Phenolic compounds from ginger, called gingerols, have been demonstrated to have antioxidant and anti-inflammatory effects. We investiga...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues FA,Prata MM,Oliveira IC,Alves NT,Freitas RE,Monteiro HS,Silva JA,Vieira PC,Viana DA,Libório AB,Havt A

更新日期：2014-01-01 00:00:00

abstract：:VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding site of PB2. VX-787 binds the cap-bi...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrn RA,Jones SM,Bennett HB,Bral C,Clark MP,Jacobs MD,Kwong AD,Ledeboer MW,Leeman JR,McNeil CF,Murcko MA,Nezami A,Perola E,Rijnbrand R,Saxena K,Tsai AW,Zhou Y,Charifson PS

更新日期：2015-03-01 00:00:00