Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.

abstract：:In 1989 and 1990, a large number of ampicillin-resistant strains of Enterococcus faecium were isolated from infected patients treated at intensive care units in Berlin, Germany. Twenty-five clinical isolates, including five different biotypes as classified by acid production from various sugars and a wide range of sus...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare I,Rodloff AC,Wagner J,Witte W,Hakenbeck R

更新日期：1992-04-01 00:00:00

abstract：:Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lo...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaturvedi V,Ramani R,Ghannoum MA,Killian SB,Holliday N,Knapp C,Ostrosky-Zeichner L,Messer SA,Pfaller MA,Iqbal NJ,Arthington-Skaggs BA,Vazquez JA,Sein T,Rex JH,Walsh TJ

更新日期：2008-04-01 00:00:00

abstract：:We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147-151, 1974), and the entire pncA nucleotide se...

journal_title：Antimicrobial agents and chemotherapy

authors： Morlock GP,Crawford JT,Butler WR,Brim SE,Sikes D,Mazurek GH,Woodley CL,Cooksey RC

更新日期：2000-09-01 00:00:00

abstract：:The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis. These antibiotics are also being investigated for their targeting of the catalytic RNAs involved in viral replicat...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomas MG,Chan YA,Ozanick SG

更新日期：2003-09-01 00:00:00

abstract：:A simple technique with antibiotic-impregnated disks has been developed to demonstrate the antibiotic synergism of penicillins and aminoglycosides against enterococci. The two antibiotic disks are placed on inoculated plates so that the distance between their centers is less than the sum of the two radii of their prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee WS,Komarmy L

更新日期：1975-01-01 00:00:00

abstract：:Resistance to 5-fluorocytosine was studied in 137 independent Candida albicans clinical isolates. Seventy-eight isolates (57%) were susceptible; 51 isolates (37%) were partially resistant; 8 isolates (6%) were highly resistant. All partially resistant isolates gave rise to variants which were highly resistant. Some su...

journal_title：Antimicrobial agents and chemotherapy

authors： Defever KS,Whelan WL,Rogers AL,Beneke ES,Veselenak JM,Soll DR

更新日期：1982-11-01 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:Tobramycin-resistant burn wound isolates of Klebsiella pneumoniae and Enterobacter cloacae, together with Escherichia coli K-12 transconjugants from these two strains, were examined for plasmid deoxyribonucleic acid (DNA). All the resistant strains contained a common, high-molecular-weight, covalently closed circular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Elwell LP,Inamine JM,Minshew BH

更新日期：1978-02-01 00:00:00

abstract：:Mupirocin is a topical antimicrobial used to decolonize patients who carry methicillin-resistant Staphylococcus aureus (MRSA), and the topical agent retapamulin may be a potential alternative therapy. The goal of this study was to determine the in vitro activity of retapamulin as well as a panel of 15 antimicrobial ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrington AT,Black JA,Clarridge JE 3rd

更新日期：2015-12-14 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:The spread of antibiotic-resistant bacteria presents a global health challenge. Efficient surveillance of bacteria harboring antibiotic resistance genes (ARGs) is a critical aspect to controlling the spread. Increased access to microbial genomic data from many diverse populations informs this surveillance but only whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim HL,Rodriguez RD,Morris SK,Zhao S,Donato JJ

更新日期：2020-10-20 00:00:00

abstract：:Two ceftazidime-resistant variants of Pseudomonas aeruginosa (PA-48, PA-60), obtained from cardiac vegetations of rabbits with endocarditis receiving ceftazidime therapy, were studied for mechanisms of resistance. Both resistant variants were stably derepressed for the type Id beta-lactamase, which was ceftazidime ind...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Peters J,Parr TR Jr,Chan L,Hancock RE

更新日期：1987-02-01 00:00:00

abstract：:Ribavirin was inactive against the rotavirus of murine gastroenteritis; this may be due to the presence of guanosine inhibitors in the gut. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoub BD,Prozesky OW

更新日期：1977-10-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. Pseudomonas aeruginosa is a particularly difficult pathogen to treat effectively because of the plethora of resistance mechanisms it carries. Fosfomycin is an agent discovered ci...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Neely MN,Yamada WM,Duncanson B,Brown D,Maynard M,Vicchiarelli M,Louie A

更新日期：2018-11-26 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen YT,Liao TL,Liu YM,Lauderdale TL,Yan JJ,Tsai SF

更新日期：2009-03-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:Antibiotic therapy with penicillin, doxycycline, and ceftriaxone has proven to be effective for the treatment of Lyme borreliosis. In some patients, however, it was noticed that borreliae can survival in the tissues in spite of seemingly adequate therapy. For a better understanding of this phenomenon, we investigated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersten A,Poitschek C,Rauch S,Aberer E

更新日期：1995-05-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis (HVH) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. Treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(I:C)] significantly increased the mean survival time and markedly altered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-06-01 00:00:00

abstract：:Although the use of probiotics based on Bacillus strains to fight off intestinal pathogens and antibiotic-associated diarrhea is widespread, the mechanisms involved in producing their beneficial effects remain unclear. Here, we studied the ability of compounds secreted by the probiotic Bacillus clausii strain O/C to c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ripert G,Racedo SM,Elie AM,Jacquot C,Bressollier P,Urdaci MC

更新日期：2016-05-23 00:00:00

abstract：:The susceptibilities of 430 Campylobacter jejuni strains and 79 C. coli strains to six antimicrobial agents were tested and analyzed. The two sets of strains originated from retail market chicken and turkey samples and from humans, respectively, in Berlin, Germany. Two groups of isolates, one dating from 1991 and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luber P,Wagner J,Hahn H,Bartelt E

更新日期：2003-12-01 00:00:00

abstract：:The ability of novobiocin to eliminate (cure) the wild-type plasmid pMG110 from Escherichia coli has been compared with that of other inhibitors of the gyrase B subunit and of the gyrase A subunit. Novobiocin eliminated pMG110 , producing over 99% plasmid loss at concentrations two- to eightfold below the MIC for bact...

journal_title：Antimicrobial agents and chemotherapy

authors： Hooper DC,Wolfson JS,McHugh GL,Swartz MD,Tung C,Swartz MN

更新日期：1984-05-01 00:00:00

abstract：:The pharmacokinetics of cefepime were studied in 12 adult patients in intensive care units during continuous venovenous hemofiltration (CVVH) or continuous venovenous hemodiafiltration (CVVHDF) with a Multiflow60 AN69HF 0.60-m(2) polyacrylonitrile hollow-fiber membrane (Hospal Industrie, Meyzieu, France). Patients (me...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-11-01 00:00:00

abstract：:The effects of binding and the bactericidal action of vancomycin on the arrangement and mobilities of cell wall polymers in Bacillus licheniformis were investigated by (15)N nuclear magnetic resonance spectroscopy. The bactericidal action of vancomycin led to reduced mobilities of cell wall teichoic acid and teichuron...

journal_title：Antimicrobial agents and chemotherapy

authors： Irving CS,Lapidot A

更新日期：1978-11-01 00:00:00

abstract：:Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nie B,Long T,Ao H,Zhou J,Tang T,Yue B

更新日期：2016-12-27 00:00:00

abstract：:GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Streptococcus pneumoniae a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoover J,Lewandowski T,Straub RJ,Novick SJ,DeMarsh P,Aubart K,Rittenhouse S,Zalacain M

更新日期：2015-10-19 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. Cefamandole had activity equivalent to cefazolin against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Cefamandole was more active than cephalothin or cefazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Shemonsky NK,Carrizosa J,Levison ME

更新日期：1975-12-01 00:00:00

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00