Inhibition of mouse LM cell replication by trifluorothymidine: role of cytosolic deoxythymidine kinase.

abstract：:SCY-078 is an orally active antifungal whose target is the β-(1,3)-d-glucan synthase (GS). We evaluated the spontaneous emergence of SCY-078-resistant Candida glabrata isolates following drug exposure in vitro Resistant isolates were analyzed using broth microdilution methodology and FKS sequencing. The kinetic inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiménez-Ortigosa C,Perez WB,Angulo D,Borroto-Esoda K,Perlin DS

更新日期：2017-08-24 00:00:00

abstract：:A hemoglobin-supplemented medium composed of Columbia agar base supplemented with 1% hemoglobin and 1% Polyvitex was used to investigate the in vitro activity of 29 antimicrobial agents against Capnocytophaga species. Clindamycin was the most active agent, with all strains being inhibited by 0.06 microgram/ml or less....

journal_title：Antimicrobial agents and chemotherapy

authors： Rummens JL,Gordts B,Van Landuyt HW

更新日期：1986-11-01 00:00:00

abstract：:Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizushima T,Matsuo M,Sekimizu K

更新日期：1997-01-01 00:00:00

abstract：:Twenty-three healthy male and female subjects received single 100-mg oral doses of rimantadine hydrochloride on two occasions in an open-label, sequential design with a 6-day washout between doses. The first dose of rimantadine was administered alone, and the second dose was administered concomitantly with cimetidine ...

journal_title：Antimicrobial agents and chemotherapy

authors： Holazo AA,Choma N,Brown SY,Lee LF,Wills RJ

更新日期：1989-06-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 x 10(-5) M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wanda P,Cupp J,Snipes W,Deith A,Rucinsky T,Polish L,Sands J

更新日期：1976-07-01 00:00:00

abstract：:The dissociation constants for binding to ribosomes from Escherichia coli and concentrations at which 50% inhibition of [(14)C]erythromycin binding to ribosomes occurred were determined for 45 erythromycin analogues. These values were correlated with their antibacterial activities against Bacillus subtilis. Compounds ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pestka S,Lemahieu R,Miller P

更新日期：1974-10-01 00:00:00

abstract：:Antiviral screens have proved useful for the identification of novel human immunodeficiency virus type 1 (HIV-1) inhibitors. In this study, we describe an HIV-1 full replication (HIV-1 Rep) assay that incorporates all of the targets required for replication in T-cell lines, including the HIV-1 Vif gene. The HIV-1 Rep ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao J,Isaacson J,Patick AK,Blair WS

更新日期：2005-09-01 00:00:00

abstract：:Iron-sulfur flavoproteins (Isf) are flavin mononucleotide (FMN)- and FeS cluster-containing proteins commonly encountered in anaerobic prokaryotes. However, with the exception of Isf from Methanosarcina thermophila, which participates in oxidative stress management by removing oxygen and hydrogen peroxide, none of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Smutná T,Pilarová K,Tarábek J,Tachezy J,Hrdý I

更新日期：2014-06-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:Amoxicillin when administered with gastric acid suppressors has been shown to be effective in eradication of Helicobacter pylori in 50 to 80% of subjects. The aim of this investigator-blind crossover study was to determine if gastric mucosal amoxicillin uptake was affected by increasing gastric juice pH. Fifteen male ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardaci G,Lambert JR,King RG,Onishi N,Midolo P

更新日期：1995-09-01 00:00:00

abstract：:Carbapenemase-producing Enterobacteriaceae isolates (n = 110) from health care centers in central Indiana (from 2010 to 2013) were tested for susceptibility to combinations of avibactam (4 μg/ml) with ceftazidime, ceftaroline, or aztreonam. MIC50/MIC90 values were 1/2 μg/ml (ceftazidime-avibactam), 0.5/2 μg/ml (ceftar...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Kashikar A,Brown CA,Denys G,Bush K

更新日期：2017-07-25 00:00:00

abstract：:The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Welch EC,Khan J,Pervez M,Doherty JA,Reichley RM,Kollef MH

更新日期：2010-05-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:Two 3-alkyl-substituted 2-hydroxy-1,4-naphthoquinones, NSC 113452 (NSC52) and NSC 113455 (NSC55), were evaluated for activity against Toxoplasma gondii in vitro and in murine models of acute toxoplasmosis. In vitro, both NSC52 and NSC55 significantly inhibited intracellular replication of T. gondii. In vivo, each comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Nasr M,Araujo FG

更新日期：1998-09-01 00:00:00

abstract：:In 24 patients with hepatitic C virus (HCV) infection who participated in a randomized trial with alpha 2B interferon, HCV RNA analysis by the polymerase chain reaction with two separate primer sets was performed at weeks 0, 4, and 24 and during a follow-up period of 6 to 9 months. Prior to therapy all patients were H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kleter GE,Brouwer JT,Heijtink RA,Schalm SW,Quint WG

更新日期：1993-03-01 00:00:00

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Back AF,Babst AF,Taylor D,Rice RJ

更新日期：1993-07-01 00:00:00

abstract：:Replication of hepatitis C virus (HCV) RNA is catalyzed by the virally encoded RNA-dependent RNA polymerase NS5B. It is believed that the viral polymerase utilizes a de novo or primer-independent mechanism for initiation of RNA synthesis. Our previous work has shown that dinucleotides were efficient initiation molecul...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhong W,An H,Barawkar D,Hong Z

更新日期：2003-08-01 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:Moxifloxacin (MXF) is a fluoroquinolone antibiotic that is effective against respiratory infections. However, the mechanisms of MXF lung diffusion are unknown. Active transport in other tissues has been suggested for several members of the fluoroquinolone family. In this study, transport of MXF was systematically inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Brillault J,De Castro WV,Harnois T,Kitzis A,Olivier JC,Couet W

更新日期：2009-04-01 00:00:00

abstract：:The rabbit kidney cell line LLC-RK1 was tested for its ability to discriminate the toxicities of six cephalosporin antibiotics according to their in vivo nephrotoxic potentials in rabbits. With the exception of cephalothin, which was markedly toxic to kidney cells in vitro, a good correlation between in vitro toxicity...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams PD,Laska DA,Tay LK,Hottendorf GH

更新日期：1988-03-01 00:00:00

abstract：:Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based therapies represents an emerging strategy for drug discovery. The ubiquitin-proteasome system is a central mode of signalin...

journal_title：Antimicrobial agents and chemotherapy

authors： Passalacqua KD,Charbonneau ME,Donato NJ,Showalter HD,Sun D,Wen B,He M,Sun H,O'Riordan MX,Wobus CE

更新日期：2016-06-20 00:00:00

abstract：:ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae In this study, we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical is...

journal_title：Antimicrobial agents and chemotherapy

authors： Santos-Lopez A,Bernabe-Balas C,Ares-Arroyo M,Ortega-Huedo R,Hoefer A,San Millan A,Gonzalez-Zorn B

更新日期：2017-01-24 00:00:00

abstract：:Mycograb (NeuTec Pharma plc) is a human genetically recombinant antibody against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with recovery in patients with invasive candidiasis who are receiving amphotericin B (AMB). Using in vitro assays developed for efficacy assessment of chemother...

journal_title：Antimicrobial agents and chemotherapy

authors： Matthews RC,Rigg G,Hodgetts S,Carter T,Chapman C,Gregory C,Illidge C,Burnie J

更新日期：2003-07-01 00:00:00

abstract：:Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kid...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Donnell JN,Rhodes NJ,Lodise TP,Prozialeck WC,Miglis CM,Joshi MD,Venkatesan N,Pais G,Cluff C,Lamar PC,Briyal S,Day JZ,Gulati A,Scheetz MH

更新日期：2017-10-24 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP), are relatively low...

journal_title：Antimicrobial agents and chemotherapy

authors： Font E,Rosario O,Santana J,García H,Sommadossi JP,Rodriguez JF

更新日期：1999-12-01 00:00:00

abstract：:The influence of a mission hospital on the evolution of antibiotic resistance in coliform bacteria from a remote antibiotic-free Xhosa community and environment is described. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Burt SJ,Woods DR

更新日期：1976-09-01 00:00:00

abstract：:A fosmid library from genomic DNA of Streptomyces viridochromogenes DSM 40736 was constructed and screened for the presence of genes known to be involved in the biosynthesis of phosphinothricin tripeptide (PTT). Eight positives were identified, one of which was able to confer PTT biosynthetic capability upon Streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Blodgett JA,Zhang JK,Metcalf WW

更新日期：2005-01-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeaman MR,Cheng D,Desai B,Kupferwasser LI,Xiong YQ,Gank KD,Edwards JE Jr,Bayer AS

更新日期：2004-08-01 00:00:00

abstract：:An efficient and reproducible procedure was developed for extracting aminoglycosides from renal cortical tissue. It involves a double homogenization and two rinsings with trichloroacetic acid. A higher recovery is obtained compared with that of other previously reported methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giuliano RA,Verpooten GA,Pollet DE,Verbist L,Scharpé SL,De Broe ME

更新日期：1984-06-01 00:00:00