Correlation of effects of erythromycin analogues on intact bacteria and on [14C]erythromycin binding to Escherichia coli ribosomes.

abstract：:Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro potency, in vitro resistance profile, and activity in combination wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng G,Tian Y,Doehle B,Peng B,Corsa A,Lee YJ,Gong R,Yu M,Han B,Xu S,Dvory-Sobol H,Perron M,Xu Y,Mo H,Pagratis N,Link JO,Delaney W

更新日期：2016-01-11 00:00:00

abstract：:The minimal inhibitory concentration of temocillin (BRL 17421) against 476 clinical isolates was determined by an agar dilution method. Temocillin was active against most of the Enterobacteriaceae, Haemophilus, and Neisseria strains tested. The compound showed low activity or was inactive against Bacteroides, Campylob...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Landuyt HW,Pyckavet M,Lambert A,Boelaert J

更新日期：1982-10-01 00:00:00

abstract：:Lipids in fresh human milk do not inactivate viruses but become antiviral after storage of the milk for a few days at 4 or 23 degrees C. The appearance of antiviral activity depends on active milk lipases and correlates with the release of free fatty acids in the milk. A number of fatty acids which are normal componen...

journal_title：Antimicrobial agents and chemotherapy

authors： Thormar H,Isaacs CE,Brown HR,Barshatzky MR,Pessolano T

更新日期：1987-01-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nair S,Desai S,Poonacha N,Vipra A,Sharma U

更新日期：2016-11-21 00:00:00

abstract：:Hard-tick-borne relapsing fever (HTBRF) is an emerging infectious disease throughout the temperate zone caused by the relapsing-fever spirochete Borrelia miyamotoi Antibiotic treatment of HTBRF is empirically based on the treatment of Lyme borreliosis; however, the antibiotic susceptibility of B. miyamotoi has not bee...

journal_title：Antimicrobial agents and chemotherapy

authors： Koetsveld J,Draga ROP,Wagemakers A,Manger A,Oei A,Visser CE,Hovius JW

更新日期：2017-08-24 00:00:00

abstract：:Concentration-QTc modeling was applied to pretomanid, a new nitroimidazooxazine antituberculosis drug. Data came from eight phase 2 and phase 3 studies. Besides pretomanid alone, various combinations with bedaquiline, linezolid, moxifloxacin, and pyrazinamide were considered; special attention was given to the bedaqui...

journal_title：Antimicrobial agents and chemotherapy

authors： Li H,Salinger DH,Everitt D,Li M,Del Parigi A,Mendel C,Nedelman JR

更新日期：2019-09-23 00:00:00

abstract：:Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

更新日期：1995-08-01 00:00:00

abstract：:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

更新日期：2018-06-26 00:00:00

abstract：:Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunell M,Webber MA,Kotilainen P,Lilly AJ,Caddick JM,Jalava J,Huovinen P,Siitonen A,Hakanen AJ,Piddock LJ

更新日期：2009-09-01 00:00:00

abstract：:The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Binder U,Maurer E,Lackner M,Lass-Flörl C

更新日期：2015-03-01 00:00:00

abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

journal_title：Antimicrobial agents and chemotherapy

authors： Teuber M,Bader J

更新日期：1976-01-01 00:00:00

abstract：:The emergence of human immunodeficiency virus type 1 (HIV-1) strains resistant to highly active antiretroviral therapy necessitates continued drug discovery for the treatment of HIV-1 infection. Most current drug discovery strategies focus upon a single aspect of HIV-1 replication. A virus-cell-based assay, which can ...

journal_title：Antimicrobial agents and chemotherapy

authors： Adelson ME,Pacchia AL,Kaul M,Rando RF,Ron Y,Peltz SW,Dougherty JP

更新日期：2003-02-01 00:00:00

abstract：:Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for...

journal_title：Antimicrobial agents and chemotherapy

authors： Veiga MI,Osório NS,Ferreira PE,Franzén O,Dahlstrom S,Lum JK,Nosten F,Gil JP

更新日期：2014-12-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Bacteriophage therapy of bacterial infections has received renewed attention owing to the increasing prevalence of antibiotic-resistant pathogens. A side effect of many antibiotics as well as of phage therapy with lytic phage is the release of cell wall components, e.g., endotoxins of gram-negative bacteria, which med...

journal_title：Antimicrobial agents and chemotherapy

authors： Hagens S,Habel A,von Ahsen U,von Gabain A,Bläsi U

更新日期：2004-10-01 00:00:00

abstract：:MIC methodology was used to test the antibacterial activity of XRP 2868, a new oral combination of two semisynthetic streptogramins, RPR 132552A and RPR 202868, compared to activities of other antibacterial agents against pneumococci, Haemophilus influenzae, and Haemophilus parainfluenzae. For 261 pneumococci, XRP 286...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Kelly LM,Lin G,Bryskier A,Couturier C,Jacobs MR,Appelbaum PC

更新日期：2003-10-01 00:00:00

abstract：:The binding of penicillin G to a stable L-form from Staphylococcus aureus followed saturation-type kinetics with saturation achieved at 0.75 nmol/ml, the same as with its parent strain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H

更新日期：1976-03-01 00:00:00

abstract：:Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. A target area under the concentration-time curve from 0 to 24 h (AUC0-24) of 40 to 50 μg · h/ml is recommended. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Q,Leroux S,Shi HY,Xu HY,Kou C,Khan MW,Jacqz-Aigrain E,Zhao W

更新日期：2018-04-26 00:00:00

abstract：:Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are copre...

journal_title：Antimicrobial agents and chemotherapy

authors： Desta Z,Soukhova NV,Flockhart DA

更新日期：2001-02-01 00:00:00

abstract：:The Cpx stress response is widespread among Enterobacteriaceae We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA....

journal_title：Antimicrobial agents and chemotherapy

authors： Masi M,Pinet E,Pagès JM

更新日期：2020-05-21 00:00:00

abstract：:Acinetobacter baumannii has emerged as a serious problematic pathogen due to the ever-increasing presence of antibiotic resistance, demonstrating a need for novel, broad-spectrum antimicrobial therapeutic options. Antimicrobial nanoemulsions are emulsified mixtures of detergent, oil, and water (droplet size, 100 to 80...

journal_title：Antimicrobial agents and chemotherapy

authors： Hwang YY,Ramalingam K,Bienek DR,Lee V,You T,Alvarez R

更新日期：2013-08-01 00:00:00

abstract：:The in vivo and in vitro determination of significant intracellular stavudine (d4T) triphosphate (d4TTP) concentrations in human immunodeficiency virus (HIV)-infected subjects and NS-1 cells treated with zidovudine (ZDV) has recently been reported. This study was conducted to corroborate these findings with in vivo sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Meléndez M,Blanco R,Delgado W,García R,Santana J,García H,Rosario O,Rodríguez JF

更新日期：2006-03-01 00:00:00

abstract：:The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 microCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in study B (n = 7). Su...

journal_title：Antimicrobial agents and chemotherapy

authors： Stone JA,Xu X,Winchell GA,Deutsch PJ,Pearson PG,Migoya EM,Mistry GC,Xi L,Miller A,Sandhu P,Singh R,deLuna F,Dilzer SC,Lasseter KC

更新日期：2004-03-01 00:00:00

abstract：:A novel and highly accurate diagnostic assay platform was established for rapid identification of FKS mutations associated with echinocandin resistance in Candida glabrata The assay platform uses allele-specific molecular beacon and DNA melt analysis following asymmetric PCR. A dual assay for FKS1 and FKS2 was develop...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Y,Nagasaki Y,Kordalewska M,Press EG,Shields RK,Nguyen MH,Clancy CJ,Perlin DS

更新日期：2016-10-21 00:00:00

abstract：:The in vitro activities of two new antimicrobial agents, apalcillin and cefpiramide (SM-1652), were evaluated against 324 strains of anaerobic bacteria. Apalcillin (a penicillin derivative) and cefpiramide (a semisynthetic cephalosporin) were compared with piperacillin, moxalactam, and cefoxitin. Organisms studied inc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler H,Carter WT,Harris B,Finegold SM

更新日期：1984-02-01 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infections, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk but might increase the risks of renal or liver toxicity or Clostridium diffici...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Huskey RL,Tang L,Inaba H,Gaur AH,Ribeiro R,Rubnitz JE,Wolf J

更新日期：2018-02-23 00:00:00

abstract：:The effect of the cephalosporin precursors and amino acids of the aspartic acid family on antibiotic production by Streptomyces clavuligerus was investigated DL-meso-Diaminopimelate and L-lysine each stimulated specific antibiotic production by 75%. A fourfold increase in specific production was obtained by simultaneo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendelovitz S,Aharonowitz Y

更新日期：1982-01-01 00:00:00