Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event.


:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is the result of an apparent gene conversion-like event.


Gentry DR,Holmes DJ




Has Abstract


2008-03-01 00:00:00














  • Effect of grapefruit juice on clarithromycin pharmacokinetics.

    abstract::To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromyci...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cheng KL,Nafziger AN,Peloquin CA,Amsden GW

    更新日期:1998-04-01 00:00:00

  • In vitro activity of a new fluoroquinolone, CP-99,219, against strains of Neisseria gonorrhoeae.

    abstract::The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Knapp JS,Neal SW,Parekh MC,Rice RJ

    更新日期:1995-04-01 00:00:00

  • In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.

    abstract::We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficac...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mario DN,Guarro J,Santurio JM,Alves SH,Capilla J

    更新日期:2015-08-01 00:00:00

  • Effect of cefamandole nafate on the toxicity of tobramycin.

    abstract::Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wold JS,Turnipseed SA,Broddle WD,Owen NV

    更新日期:1977-10-01 00:00:00

  • Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.

    abstract::The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Johnson BC,Métifiot M,Pommier Y,Hughes SH

    更新日期:2012-01-01 00:00:00

  • Inhibition of herpes simplex virus type 1 replication by halothane.

    abstract::Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein faile...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bedows E,Holland TC,Knight PR

    更新日期:1986-05-01 00:00:00

  • Pharmacokinetics of oral and intravenous ofloxacin in children with multidrug-resistant typhoid fever.

    abstract::The pharmacokinetics of oral and intravenous ofloxacin (7.5 of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bethell DB,Day NP,Dung NM,McMullin C,Loan HT,Tam DT,Minh LT,Linh NT,Dung NQ,Vinh H,MacGowan AP,White LO,White NJ

    更新日期:1996-09-01 00:00:00

  • In vitro and in vivo activities of macrolides against Mycobacterium leprae.

    abstract::We previously demonstrated the potent in vitro activity of erythromycin against Mycobacterium leprae as determined by its effect on ATP pools and rates of palmitate oxidation and phenolic glycolipid I synthesis. In the present study, the relative in vitro activities of a number of new macrolides with superior pharmaco...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Franzblau SG,Hastings RC

    更新日期:1988-12-01 00:00:00

  • First Report of the Carbapenemase Gene blaOXA-499 in Acinetobacter pittii.

    abstract::We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: D'Souza R,Pinto NA,Higgins PG,Hwang I,Yong D,Choi J,Lee K,Chong Y

    更新日期:2017-04-24 00:00:00

  • Mutation of RNA polymerase beta subunit (rpoB) promotes hVISA-to-VISA phenotypic conversion of strain Mu3.

    abstract::The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

    更新日期:2011-09-01 00:00:00

  • Antibiofilm Activity and Synergistic Inhibition of Staphylococcus aureus Biofilms by Bactericidal Protein P128 in Combination with Antibiotics.

    abstract::P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nair S,Desai S,Poonacha N,Vipra A,Sharma U

    更新日期:2016-11-21 00:00:00

  • Comparative activities of Bay n7133, ICI 153,066, and ketoconazole in murine cryptococcosis.

    abstract::Two new antifungal triazoles, BAY n7133 and ICI 153,066, were compared with ketoconazole in treatment of mice challenged intraperitoneally with Cryptococcus neoformans. At high challenge doses, thymus-containing normal mice had prolonged survival after treatment with BAY n7133. Athymic mice, which have severely defici...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Graybill JR,Kaster SR,Drutz DJ

    更新日期:1983-12-01 00:00:00

  • Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus.

    abstract::Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bryson D,Hettle AG,Boraston AB,Hobbs JK

    更新日期:2020-02-21 00:00:00

  • Efficacy of ciprofloxacin for experimental endocarditis caused by methicillin-susceptible or -resistant strains of Staphylococcus aureus.

    abstract::The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

    更新日期:1986-09-01 00:00:00

  • Stepwise acquisition of multiple drug resistance by beta-hemolytic streptococci and difference in resistance pattern by type.

    abstract::We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Miyamoto Y,Takizawa K,Matsushima A,Asai Y,Nakatsuka S

    更新日期:1978-03-01 00:00:00

  • Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro.

    abstract::BILN 2061 is a novel, specific hepatitis C virus (HCV) NS3 serine protease inhibitor discovered by Boehringer Ingelheim that has shown potent activity against HCV replicons in tissue culture and is currently under clinical investigation for the treatment of HCV infection. The poor fidelity of the HCV RNA-dependent RNA...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lu L,Pilot-Matias TJ,Stewart KD,Randolph JT,Pithawalla R,He W,Huang PP,Klein LL,Mo H,Molla A

    更新日期:2004-06-01 00:00:00

  • Cefamandole bile levels in patients with hepatobiliary disease.

    abstract::Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

    更新日期:1982-12-01 00:00:00

  • Pharmacokinetics of cefepime in patients with thermal burn injury.

    abstract::The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and uri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Bonapace CR,White RL,Friedrich LV,Norcross ED,Bosso JA

    更新日期:1999-12-01 00:00:00

  • Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis.

    abstract::The activity of gemifloxacin against Haemophilus influenzae and Moraxella catarrhalis was compared to those of 11 other agents. All quinolones were very active (MICs,

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Davies TA,Kelly LM,Hoellman DB,Ednie LM,Clark CL,Bajaksouzian S,Jacobs MR,Appelbaum PC

    更新日期:2000-03-01 00:00:00

  • Musculoskeletal safety outcomes of patients receiving daptomycin with HMG-CoA reductase inhibitors.

    abstract::Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

    更新日期:2014-10-01 00:00:00

  • Artifactual depression of serum glutamic oxaloacetic transaminase by metronidazole.

    abstract::Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rissing JP,Newman C,Moore WL Jr

    更新日期:1978-10-01 00:00:00

  • High-throughput human immunodeficiency virus type 1 (HIV-1) full replication assay that includes HIV-1 Vif as an antiviral target.

    abstract::Antiviral screens have proved useful for the identification of novel human immunodeficiency virus type 1 (HIV-1) inhibitors. In this study, we describe an HIV-1 full replication (HIV-1 Rep) assay that incorporates all of the targets required for replication in T-cell lines, including the HIV-1 Vif gene. The HIV-1 Rep ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cao J,Isaacson J,Patick AK,Blair WS

    更新日期:2005-09-01 00:00:00

  • Pharmacokinetics of ampicillin and sulbactam in pediatric patients.

    abstract::Intravenous ampicillin-sulbactam is effective in the treatment of various infections in adults, but little is known about the pharmacokinetics (PK) of ampicillin-sulbactam in children. The objective of this study was to determine the PK of ampicillin and sulbactam in pediatric patients with intra-abdominal infection, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Nahata MC,Vashi VI,Swanson RN,Messig MA,Chung M

    更新日期:1999-05-01 00:00:00

  • In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.

    abstract::We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Palomares F,Palencia G,Pérez R,González-Esquivel D,Castro N,Cook HJ

    更新日期:2004-06-01 00:00:00

  • Exudate levels and bactericidal activity of cefazolin in a new local infection system using rat granuloma pouches.

    abstract::An experimental local infection system has been developed in which exudates are induced with croton oil in granuloma pouches of rats. This system provided a suitable model for the evaluation of the therapeutic effect of two antibiotics, cefazolin and cephalothin. Exudate levels of cefazolin were found to be higher tha...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nishida M,Murakawa T

    更新日期:1977-06-01 00:00:00

  • In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates.

    abstract::The activities of daptomycin, a cyclic lipopeptide, and eight other agents were determined against 338 strains of gram-positive anaerobic bacteria and corynebacteria by the NCCLS reference agar dilution method with supplemented brucella agar for the anaerobes and Mueller-Hinton agar for the corynebacteria. The daptomy...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

    更新日期:2003-01-01 00:00:00

  • Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

    abstract::Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need to administer compounds intravenously. We have begun a program to pursue lead optimization around MDL 73811,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barker RH Jr,Liu H,Hirth B,Celatka CA,Fitzpatrick R,Xiang Y,Willert EK,Phillips MA,Kaiser M,Bacchi CJ,Rodriguez A,Yarlett N,Klinger JD,Sybertz E

    更新日期:2009-05-01 00:00:00

  • Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model.

    abstract::Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a neutropenic murine lung in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Crandon JL,Kuti JL,Nicolau DP

    更新日期:2010-12-01 00:00:00

  • Occurrence of rpoB mutations in isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis isolates from Germany.

    abstract::Four out of 143 phenotypically isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis strains that were isolated from patients in Germany in 2011 had mutations in the rifampin resistance-determining region of rpoB. After performing drug susceptibility testing (DST) with two methods, the proportion met...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Andres S,Hillemann D,Rüsch-Gerdes S,Richter E

    更新日期:2014-01-01 00:00:00

  • Single-dose and steady-state pharmacokinetics of a novel microfluidized suspension of atovaquone in human immunodeficiency virus-seropositive patients.

    abstract::The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

    更新日期:1996-03-01 00:00:00