Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.

abstract：:A novel plasmid-mediated metallo-beta-lactamase (IMP-9) is described in seven isolates of Pseudomonas aeruginosa from Guangzhou, China, isolated in 2000. The gene was carried on a large (approximately 450-kb) IncP-2 conjugative plasmid. This is the first report of carriage of bla(IMP) genes on such large plasmids. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong J,Hynes MF,Ye H,Chen H,Yang Y,M'zali F,Hawkey PM

更新日期：2006-01-01 00:00:00

abstract：:Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

journal_title：Antimicrobial agents and chemotherapy

authors： Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

更新日期：2020-12-16 00:00:00

abstract：:As drug resistance continues to grow, treatment strategies that turn resistance into a disadvantage for the organism will be increasingly relied upon to treat infections and to lower the rate of multidrug resistance. The majority of work in this area has investigated how resistance evolution toward a single antibiotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez de Evgrafov MC,Faza M,Asimakopoulos K,Sommer MOA

更新日期：2020-12-16 00:00:00

abstract：:Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum...

journal_title：Antimicrobial agents and chemotherapy

authors： Theodos CM,Griffiths JK,D'Onfro J,Fairfield A,Tzipori S

更新日期：1998-08-01 00:00:00

abstract：:Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Sá Cavalcanti FL,Mendes-Marques CL,Vasconcelos CR,de Lima Campos T,Rezende AM,Xavier DE,Leal NC,de-Melo-Neto OP,de Morais MM,Leal-Balbino TC

更新日期：2016-12-27 00:00:00

abstract：:In a crossover study, single doses of netilmicin and gentamicin were administered intramuscularly, each at 1.0 and 2.5 mg/kg. The serum concentrations, analyzed by a two-compartment open model with a first-order absorption, indicated that the pharmacokinetics of the drugs are essentially the same. Both drugs were rapi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chung M,Costello R,Symchowicz S

更新日期：1980-02-01 00:00:00

abstract：:A reverse-phase, high-pressure liquid chromatographic method for the rapid and quantitative determination of ketoconazole has been developed. Drug levels from 0.5 to 10 microgram/ml can be determined in either yeast nitrogen base medium or human serum by using an octadecylsilane column. A retention time of 4.9 +/- 0.1...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrews FA,Peterson LR,Beggs WH,Crankshaw D,Sarosi GA

更新日期：1981-01-01 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact virus sanctuaries. Ruxolitinib and tofacitinib are JAK1/2 inhibitors t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavegnano C,Detorio M,Montero C,Bosque A,Planelles V,Schinazi RF

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodyna...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaruratanasirikul S,Wongpoowarak W,Aeinlang N,Jullangkoon M

更新日期：2013-07-01 00:00:00

abstract：:The metallo-β-lactamase VIM-4, mainly found in Pseudomonas aeruginosa or Acinetobacter baumannii, was produced in Escherichia coli and characterized by biochemical and X-ray techniques. A detailed kinetic study performed in the presence of Zn²+ at concentrations ranging from 0.4 to 100 μM showed that VIM-4 exhibits a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lassaux P,Traoré DA,Loisel E,Favier A,Docquier JD,Sohier JS,Laurent C,Bebrone C,Frère JM,Ferrer JL,Galleni M

更新日期：2011-03-01 00:00:00

abstract：:Xylitol is effective in preventing acute otitis media by inhibiting the growth of Streptococcus pneumoniae. To clarify this inhibition we used fructose, which is known to block similar growth inhibition observed in Streptococcus mutans. In addition, we evaluated the efficacy of sorbitol in inhibiting the growth of pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Tapiainen T,Kontiokari T,Sammalkivi L,Ikäheimo I,Koskela M,Uhari M

更新日期：2001-01-01 00:00:00

abstract：:Stenotrophomonas maltophilia is increasingly being isolated from the respiratory tract of individuals with cystic fibrosis, and, because of its multidrug-resistant nature, the selection of suitable treatment regimens can be problematical. Etest methodology was used to facilitate MIC and antimicrobial combination testi...

journal_title：Antimicrobial agents and chemotherapy

authors： Milne KE,Gould IM

更新日期：2012-08-01 00:00:00

abstract：:Avibactam is a new non-β-lactam β-lactamase inhibitor that shows promising restoration of ceftazidime activity against microorganisms producing Ambler class A extended-spectrum β-lactamases (ESBLs) and carbapenemases such as KPCs, class C β-lactamases (AmpC), and some class D enzymes. To determine optimal dosing combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berkhout J,Melchers MJ,van Mil AC,Seyedmousavi S,Lagarde CM,Schuck VJ,Nichols WW,Mouton JW

更新日期：2015-11-02 00:00:00

abstract：:Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Sáez-Llorens X,Macias M,Maiya P,Pineros J,Jafri HS,Chatterjee A,Ruiz G,Raghavan J,Bradshaw SK,Kartsonis NA,Sun P,Strohmaier KM,Fallon M,Bi S,Stone JA,Chow JW

更新日期：2009-03-01 00:00:00

abstract：:Burkholderia pseudomallei, the causative agent of melioidosis, is inherently resistant to a variety of antibiotics including aminoglycosides, macrolides, polymyxins, and beta-lactam antibiotics. Despite resistance to many beta-lactams, ceftazidime and beta-lactamase inhibitor-beta-lactam combinations are commonly used...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Moore RA,Baker P,Woods DE

更新日期：2003-07-01 00:00:00

abstract：:Infections caused by carbapenem-resistant KPC-producing Klebsiella pneumoniae are responsible for high rates of mortality and represent a major therapeutic challenge, especially when the isolates are also resistant to colistin. We used the checkerboard method to evaluate the synergistic activity of 10 antibiotic combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tascini C,Tagliaferri E,Giani T,Leonildi A,Flammini S,Casini B,Lewis R,Ferranti S,Rossolini GM,Menichetti F

更新日期：2013-08-01 00:00:00

abstract：:Surveillance studies conducted in the United States over the last decade have revealed increasing resistance among community-acquired respiratory pathogens, especially Streptococcus pneumoniae, that may limit future options for empirical therapy. The objective of this study was to assess the scope and magnitude of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Critchley IA,Brown SD,Traczewski MM,Tillotson GS,Janjic N

更新日期：2007-12-01 00:00:00

abstract：:The biosynthetic gene cluster of lankamycin (LM), a 14-member macrolide antibiotic, is encoded on the 210-kb linear plasmid pSLA2-L in Streptomyces rochei 7434AN4. LM contains a 3-hydroxy-2-butyl group at the C-13 position, which is different from an ethyl group in erythromycin. The following two possibilities could b...

journal_title：Antimicrobial agents and chemotherapy

authors： Arakawa K,Kodama K,Tatsuno S,Ide S,Kinashi H

更新日期：2006-06-01 00:00:00

abstract：:Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting the enzymatic activities of CHIKV replication proteins. These pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Das PK,Puusepp L,Varghese FS,Utt A,Ahola T,Kananovich DG,Lopp M,Merits A,Karelson M

更新日期：2016-11-21 00:00:00

abstract：:Three structural analogs of 5-ethyl-1-benzyloxymethyl-6-(phenylthio)uracil (E-BPU) inhibited human immunodeficiency virus type 1 (HIV-1) replication without cytotoxicity in vitro and were more potent than azidothymidine and were as potent as E-BPU. The target of these compounds is HIV-1 reverse transcriptase. Reverse ...

journal_title：Antimicrobial agents and chemotherapy

authors： Piras G,Dutschman GE,Im GJ,Pan BC,Chu SH,Cheng YC

更新日期：1995-02-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:Pneumonia occurring outside of the hospital setting has traditionally been categorized as community-acquired pneumonia (CAP). However, when pneumonia is associated with health care risk factors (prior hospitalization, dialysis, residing in a nursing home, immunocompromised state), it is now more appropriately classifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Kollef KE,Reichley RM,Roubinian N,Kollef MH

更新日期：2007-10-01 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol...

journal_title：Antimicrobial agents and chemotherapy

authors： Mayers M,Rush D,Madu A,Motyl M,Miller MH

更新日期：1991-09-01 00:00:00

abstract：:Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium in...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano P,Recio S,Peláez T,González-Rivera M,Bouza E,Guinea J

更新日期：2012-01-01 00:00:00

abstract：:Spiramycins are clinically important 16-member macrolide antibiotics produced by Streptomyces ambofaciens. Biosynthetic studies have established that the earliest lactonic intermediate in spiramycin biosynthesis, the macrolactone platenolide I, is synthesized by a type I modular polyketide synthase (PKS). Platenolide ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen HC,Darbon E,Thai R,Pernodet JL,Lautru S

更新日期：2013-08-01 00:00:00

abstract：:The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Idelevich EA,Kriegeskorte A,Schleimer N,Peters G,von Eiff C,Becker K

更新日期：2018-03-27 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00