Abstract:
:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in A. baumannii isolates that had developed polymyxin B resistance in vivo compared to isolates that had developed polymyxin B resistance in vitro.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LYdoi
10.1128/AAC.01884-15subject
Has Abstractpub_date
2015-12-01 00:00:00pages
7899-902issue
12eissn
0066-4804issn
1098-6596pii
AAC.01884-15journal_volume
59pub_type
杂志文章abstract::We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This r...
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