Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis. These antibiotics are also being investigated for their targeting of the catalytic RNAs involved in viral replicat...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomas MG,Chan YA,Ozanick SG

更新日期：2003-09-01 00:00:00

abstract：:Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but ...

journal_title：Antimicrobial agents and chemotherapy

authors： Long R,Jones R,Talbot J,Mayers I,Barrie J,Hoskinson M,Light B

更新日期：2005-03-01 00:00:00

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics techniques also co...

journal_title：Antimicrobial agents and chemotherapy

authors： Vincent IM,Ehmann DE,Mills SD,Perros M,Barrett MP

更新日期：2016-03-25 00:00:00

abstract：:The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul M,Durand R,Fessi H,Rivollet D,Houin R,Astier A,Deniau M

更新日期：1997-08-01 00:00:00

abstract：:Human cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sá NP,Lima CM,Lino CI,Barbeira PJS,Baltazar LM,Santos DA,Oliveira RB,Mylonakis E,Fuchs BB,Johann S

更新日期：2017-07-25 00:00:00

abstract：:Five patients with chronic hepatitis B were treated with 8-day courses of leukocyte (alpha) interferon (5 X 10(6) U/day) and with 8-day courses of recombinant fibroblast (betaser) interferon at dosages of 5 X 10(6), 35 X 10(6), and 105 X 10(6) U/day. Inhibition of hepatitis B virus replication as evidenced by a decrea...

journal_title：Antimicrobial agents and chemotherapy

authors： Eisenberg M,Rosno S,Garcia G,Konrad MW,Gregory PB,Robinson WS,Merigan TC

更新日期：1986-01-01 00:00:00

abstract：:There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes in Staphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasive S. aureus (ISA) inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Song KH,Kim M,Kim CJ,Cho JE,Choi YJ,Park JS,Ahn S,Jang HC,Park KH,Jung SI,Yoon N,Kim DM,Hwang JH,Lee CS,Lee JH,Kwak YG,Kim ES,Park SY,Park Y,Lee KS,Lee YS,Kim HB

更新日期：2017-02-23 00:00:00

abstract：:Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Felici A,Perilli M,Segatore B,Franceschini N,Setacci D,Oratore A,Stefani S,Galleni M,Amicosante G

更新日期：1995-06-01 00:00:00

abstract：:At least four broad-spectrum efflux pumps (Mex) are involved in elevated intrinsic antibiotic resistance as well as in acquired multidrug resistance in Pseudomonas aeruginosa. Substrate specificity of the Mex pumps has been shown to be determined by the cytoplasmic membrane component (MexB, MexD, MexF, and MexY) of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Aires JR,Pechère JC,Van Delden C,Köhler T

更新日期：2002-07-01 00:00:00

abstract：:Disseminated infections caused by the Mycobacterium avium-M. intracellulare complex (MAC) are the most frequent opportunistic bacterial infections in patients with AIDS. MAC isolates are resistant to many of the standard antituberculous drugs. Failure to obtain significant activities of certain drugs is due to difficu...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT

更新日期：1996-08-01 00:00:00

abstract：:The in vitro activities of LY146032 and seven comparative antimicrobial agents against 14 species of staphylococci, streptococci, and enterococci were studied. MICs of LY146032 were less than or equal to 0.5 microgram/ml for all staphylococci, including oxacillin-resistant strains; less than or equal to 0.25 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ,Helsel VL

更新日期：1986-11-01 00:00:00

abstract：:Although information about the efficacy and safety experience with caspofungin at 50 mg/m(2) daily is available for children and adolescents, the dosing regimen in infants and toddlers 3 to 24 months of age has yet to be established. We studied the pharmacokinetics and safety of caspofungin at 50 mg/m(2) once daily in...

journal_title：Antimicrobial agents and chemotherapy

authors： Neely M,Jafri HS,Seibel N,Knapp K,Adamson PC,Bradshaw SK,Strohmaier KM,Sun P,Bi S,Dockendorf MF,Stone JA,Kartsonis NA

更新日期：2009-04-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Idelevich EA,Kriegeskorte A,Schleimer N,Peters G,von Eiff C,Becker K

更新日期：2018-03-27 00:00:00

abstract：:Ampicillin and erythromycin were shown to act synergistically in vitro against the majority of strains of Nocardia asteroides tested. With these strains, the minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- to more than 512-fold as compared with the MIC of each antibiotic acting individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Finland M,Bach MC,Garner C,Gold O

更新日期：1974-03-01 00:00:00

abstract：:Resistance of Plasmodium falciparum to drugs such as chloroquine and sulfadoxine-pyrimethamine is a major problem in malaria control. Artemisinin (ART) derivatives, particularly in combination with other drugs, are thus increasingly used to treat malaria, reducing the probability that parasites resistant to the compon...

journal_title：Antimicrobial agents and chemotherapy

authors： Afonso A,Hunt P,Cheesman S,Alves AC,Cunha CV,do Rosário V,Cravo P

更新日期：2006-02-01 00:00:00

abstract：:The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against Staphylococcus aureus, including methicillin-resistant strains, and Streptococcus pneumoniae an...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanabe A,Tokue Y,Takahashi H,Kikuchi T,Kobayashi T,Gomi K,Fujimura S,Nukiwa T

更新日期：1999-07-01 00:00:00

abstract：:The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Towner KJ,Smith MA,Cowlishaw WA

更新日期：1983-04-01 00:00:00

abstract：:Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically validated pharmaceuticals represents an attractive...

journal_title：Antimicrobial agents and chemotherapy

authors： Johansen MD,Daher W,Roquet-Banères F,Raynaud C,Alcaraz M,Maurer FP,Kremer L

更新日期：2020-10-20 00:00:00

abstract：:A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had hig...

journal_title：Antimicrobial agents and chemotherapy

authors： Brimacombe M,Hazbon M,Motiwala AS,Alland D

更新日期：2007-11-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of...

journal_title：Antimicrobial agents and chemotherapy

authors： Feldman WE,Zweighaft T

更新日期：1979-02-01 00:00:00

abstract：:We describe a rapid, precise, and simple procedure for the quantitation of azlocillin in serum and in aqueous solutions by high-pressure, reverse-phase liquid chromatography. This method uses a single precipitation step, detection by dual-wavelength monitoring (220 and 254 nm), and quantitation by comparison with an i...

journal_title：Antimicrobial agents and chemotherapy

authors： Weber A,Opheim KE,Wong K,Smith AL

更新日期：1983-11-01 00:00:00

abstract：:No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Downey AS,Chong CR,Graczyk TK,Sullivan DJ

更新日期：2008-09-01 00:00:00

abstract：:An in vitro tissue culture system consisting of reaggregated embryonic brain cells was used to evaluate the inhibition of herpes simplex type 1 (HSV-1) by several antiviral compounds. The efficacy of acyclovir, vidarabine, bromovinyldeoxyuridine, and 9-(1,3-dihydroxy-2-propoxymethyl) guanine in HSV-1-infected Vero cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Pulliam L,Panitch HS,Baringer JR,Dix RD

更新日期：1986-12-01 00:00:00

abstract：:The presence and genetic content of integrons were investigated for 37 epidemiologically unrelated multiple-drug-resistant strains of Salmonella enterica serotype Typhimurium from humans. All isolates were resistant to ampicillin, chloramphenicol, kanamycin, streptomycin, sulfonamides, and trimethoprim, as well as to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tosini F,Visca P,Luzzi I,Dionisi AM,Pezzella C,Petrucca A,Carattoli A

更新日期：1998-12-01 00:00:00

abstract：:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine...

journal_title：Antimicrobial agents and chemotherapy

authors： Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.

更新日期：2018-10-24 00:00:00