Comparison of Two Phenotypic Algorithms To Detect Carbapenemase-Producing Enterobacteriaceae.

abstract：:Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC24/MIC) of >400 as the...

journal_title：Antimicrobial agents and chemotherapy

authors： Tseng SH,Lim CP,Chen Q,Tang CC,Kong ST,Ho PC

更新日期：2018-03-27 00:00:00

abstract：:Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain bar...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu JQ,Shao K,Wang X,Wang RY,Cao YH,Yu YQ,Lou JN,Chen YQ,Zhao HZ,Zhang QQ,Weng XH,Jiang C,Zhu LP

更新日期：2014-08-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:Antibiotic resistance of biofilm-grown bacteria contributes to chronic infections, such as marginal and periapical periodontitis, which are strongly associated with Porphyromonas gingivalis. Concurrent azithromycin (AZM) administration and mechanical debridement improve the clinical parameters of periodontal tissue in...

journal_title：Antimicrobial agents and chemotherapy

authors： Maezono H,Noiri Y,Asahi Y,Yamaguchi M,Yamamoto R,Izutani N,Azakami H,Ebisu S

更新日期：2011-12-01 00:00:00

abstract：:Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day) and pefloxacin (50 mg/kg subcutaneously, twice a day). A partial knee replacement was performed with a silicone implant f...

journal_title：Antimicrobial agents and chemotherapy

authors： Crémieux AC,Mghir AS,Bleton R,Manteau M,Belmatoug N,Massias L,Garry L,Sales N,Mazière B,Carbon C

更新日期：1996-09-01 00:00:00

abstract：:The vesicular stomatitis virus cytopathic effect reduction assay is suitable to quantify polyethylene glycol-alpha interferon 2a (PEG-IFN-alpha 2a) and PEG-IFN-alpha 2b. Human serum and ribavirin did not interfere with the assay. This bioassay was successfully used for assaying PEG-IFN-alpha 2a and PEG-IFN-alpha 2b in...

journal_title：Antimicrobial agents and chemotherapy

authors： Boulestin A,Kamar N,Legrand-Abravanel F,Sandres-Saune K,Alric L,Vinel JP,Rostaing L,Izopet J

更新日期：2004-09-01 00:00:00

abstract：:The in vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of the MICs and minimum bactericidal concentrations (MBCs), timed killing, single-step and multistep mutation rates, the erythromycin indu...

journal_title：Antimicrobial agents and chemotherapy

authors： Woosley LN,Castanheira M,Jones RN

更新日期：2010-05-01 00:00:00

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00

abstract：:In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chinh NT,Quang NN,Anh CX,Thanh NX,Dai B,Birrell GW,Chavchich M,Edstein MD

更新日期：2011-09-01 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00

abstract：:Posaconazole in oral suspension must be taken multiple times a day with food (preferably a high-fat meal) to ensure adequate exposure among patients. We evaluated the effect of food on the bioavailability of a new delayed-release tablet formulation of posaconazole at the proposed clinical dose of 300 mg once daily in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersemaekers WM,Dogterom P,Xu J,Marcantonio EE,de Greef R,Waskin H,van Iersel ML

更新日期：2015-01-01 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00

abstract：:The current recommendations for intravenous (i.v.) acyclovir dosing in obese patients suggest using ideal body weight (IBW) rather than total body weight (TBW). To our knowledge, no pharmacokinetic analysis has validated this recommendation. This single-dose pharmacokinetic study was conducted in an inpatient oncology...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Cumpston A,Sweet M,Briggs F,Slain D,Wen S,Craig M,Hamadani M,Petros W

更新日期：2016-01-11 00:00:00

abstract：:In order to study the mechanism of insusceptibility of Spiroplasma citri to rifampin, we have cloned and sequenced its rpoB gene, which encodes the beta subunit of RNA polymerase. By comparison of the deduced amino acid sequence with sequences of beta subunits from susceptible and resistant bacteria, it was possible t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaurivaud P,Laigret F,Bove JM

更新日期：1996-04-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldberg I,Walker JR,Bloch K

更新日期：1973-05-01 00:00:00

abstract：:Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nie B,Long T,Ao H,Zhou J,Tang T,Yue B

更新日期：2016-12-27 00:00:00

abstract：:Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

更新日期：2020-10-20 00:00:00

abstract：:An experimental local infection system has been developed in which exudates are induced with croton oil in granuloma pouches of rats. This system provided a suitable model for the evaluation of the therapeutic effect of two antibiotics, cefazolin and cephalothin. Exudate levels of cefazolin were found to be higher tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T

更新日期：1977-06-01 00:00:00

abstract：:Antisera produced against envelope fractions of tetracycline-resistant Escherichia coli and supernatant fluid of disrupted cells of tetracycline-resistant Salmonella typhi were adsorbed with the corresponding fractions of susceptible cultures. With these sera, cross-reacting antigens were demonstrated in the following...

journal_title：Antimicrobial agents and chemotherapy

authors： Boldur I,Sompolinsky D

更新日期：1974-08-01 00:00:00

abstract：:ME1100 (arbekacin inhalation solution) is an inhaled aminoglycoside that is being developed to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were undertaken to evaluate ME1100 regimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhavnani SM,Hammel JP,Lakota EA,Safir MC,VanScoy BD,Nagira Y,Rubino CM,Sato N,Koresawa T,Kondo K,Ambrose PG

更新日期：2020-09-21 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:The antimicrobial treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections has become a great challenge for medical staff all over the world. Increasing numbers of MDR A. baumannii infections have been identified and reported, but effective clinical treatments for them are decreasing. The objective of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai Y,Liu B,Wang T,Cai Y,Liang B,Wang R,Liu Y,Wang J

更新日期：2015-03-01 00:00:00

abstract：:Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative p...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel L

更新日期：2012-04-01 00:00:00

abstract：:Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Adjei GO,Kristensen K,Goka BQ,Hoegberg LC,Alifrangis M,Rodrigues OP,Kurtzhals JA

更新日期：2008-12-01 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not impr...

journal_title：Antimicrobial agents and chemotherapy

authors： Ibrahim AS,Gebremariam T,Schwartz JA,Edwards JE Jr,Spellberg B

更新日期：2009-02-01 00:00:00

abstract：:Resistance to rifampin in Mycobacterium tuberculosis results from mutations in the gene coding for the beta subunit of RNA polymerase (rpoB). At least 95% of rifampin-resistant isolates have mutations in rpoB, and the mutations are clustered in a small region. About 40 distinct point mutations and in-frame insertions ...

journal_title：Antimicrobial agents and chemotherapy

authors： Morlock GP,Plikaytis BB,Crawford JT

更新日期：2000-12-01 00:00:00