Macrolide-resistant Mycoplasma pneumoniae pneumonia in adolescents and adults: clinical findings, drug susceptibility, and therapeutic efficacy.

abstract：:We report a microanalytical high-performance liquid chromatography method for quantitation of cefpirome (HR 810) from serum. The drug was extracted from 0.05 ml of serum with 0.2 ml of isopropanol containing beta-hydroxypropyltheophylline, the internal standard. Separations were performed on a C18 column at ambient te...

journal_title：Antimicrobial agents and chemotherapy

authors： Turley CP,Kearns GL,Jacobs RF

更新日期：1988-10-01 00:00:00

abstract：:A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncomm...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Cuesta I,Zaragoza O,Mellado E,Rodriguez-Tudela JL,Antifungal Subcommittee of European Committee on Antimicrobial Susceptibility Testing.

更新日期：2011-04-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:Intravenous ampicillin-sulbactam is effective in the treatment of various infections in adults, but little is known about the pharmacokinetics (PK) of ampicillin-sulbactam in children. The objective of this study was to determine the PK of ampicillin and sulbactam in pediatric patients with intra-abdominal infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nahata MC,Vashi VI,Swanson RN,Messig MA,Chung M

更新日期：1999-05-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwendener S,Perreten V

更新日期：2011-10-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:The resistance-nodulation-division (RND)-type efflux pump is one of the causes of the multidrug resistance of Stenotrophomonas maltophilia. The roles of the RND-type efflux pump in physiological functions and virulence, in addition to antibiotic extrusion, have attracted much attention. In this study, the contribution...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin YT,Huang YW,Chen SJ,Chang CW,Yang TC

更新日期：2015-07-01 00:00:00

abstract：:Magainins are novel polycationic peptides with broad-spectrum antimicrobial activity, including activity against gram-negative bacteria. Gram-negative bacteremia can elicit endotoxic shock that is associated with the increased formation of eicosanoids. Inhibition of eicosanoid synthesis has been shown to improve the o...

journal_title：Antimicrobial agents and chemotherapy

authors： Matera G,Cook JA,Geisel J,Ashton SH,Wise WC,Focá A,Berkowitz BA,Halushka PV

更新日期：1993-03-01 00:00:00

abstract：:BAL5788 is the water-soluble prodrug of BAL9141, a novel broad-spectrum cephalosporin with potent bactericidal activities against methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae. We investigated the safety and pharmacokinetics of BAL5788 in a double-blind, single-as...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt-Hoffmann A,Roos B,Schleimer M,Sauer J,Man A,Nashed N,Brown T,Perez A,Weidekamm E,Kovács P

更新日期：2004-07-01 00:00:00

abstract：:A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2003-09-01 00:00:00

abstract：:A clinical trial was designed to evaluate the efficacy and safety of cefotaxime, a new semisynthetic, broad-spectrum cephalosporin, in the therapy of community-and hospital-acquired pneumonias. Thirty-nine males (mean age, 65 years) were treated for 41 episodes of pneumonia. Only five patient did not have a serious un...

journal_title：Antimicrobial agents and chemotherapy

authors： Schleupner CJ,Engle JC

更新日期：1982-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel HD,Nikitin P,Gesner T,Lin JJ,Barkan DT,Ciferri C,Carfi A,Akbarnejad Yazdi T,Skewes-Cox P,Wiedmann B,Jarousse N,Zhong W,Feire A,Hebner CM

更新日期：2016-07-22 00:00:00

abstract：:A survey conducted between 1987 and 1994 at the University Hospital of Besançon, France, demonstrated a dramatic increase (from 0 to 42. 5%) in the prevalence of amoxicillin resistance among Salmonella spp. Of the 96 resistant isolates collected during this period (including 77 Typhimurium), 54 were found to produce T...

journal_title：Antimicrobial agents and chemotherapy

authors： Llanes C,Kirchgesner V,Plesiat P

更新日期：1999-10-01 00:00:00

abstract：:Although it is generally believed that bactericidal and bacteriostatic drugs should not be combined in vivo, in vitro experiments using the checkerboard dilution technique revealed no antagonism between penicillin/cephalothin and rolitetracycline but rather additive or synergistic activity of either drug combination i...

journal_title：Antimicrobial agents and chemotherapy

authors： Daschner FD

更新日期：1976-11-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetics of oral and intravenous ofloxacin (7.5 mg.kg of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethell DB,Day NP,Dung NM,McMullin C,Loan HT,Tam DT,Minh LT,Linh NT,Dung NQ,Vinh H,MacGowan AP,White LO,White NJ

更新日期：1996-09-01 00:00:00

abstract：:Recalcitrant dermatophytoses are on the rise in India. High MICs of terbinafine (TRB) and squalene epoxidase (SQLE) gene mutations conferring resistance in Trichophyton spp. have been recently documented. However, studies correlating laboratory data with clinical response to TRB in tinea corporis/cruris are lacking. F...

journal_title：Antimicrobial agents and chemotherapy

authors： Khurana A,Masih A,Chowdhary A,Sardana K,Borker S,Gupta A,Gautam RK,Sharma PK,Jain D

更新日期：2018-11-26 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of a clinical isolate of Staphylococcus aureus specifically resistant to oral cephalosporins were compared with those of a susceptible strain. In the resistant strain, PBP3 (75,000 molecular weight) was missing or had substantially (greater than 100-fold) reduced affinity for pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Georgopapadakou NH,Smith SA,Bonner DP

更新日期：1982-07-01 00:00:00

abstract：:Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sponer U,Prajakwong S,Wiedermann G,Kollaritsch H,Wernsdorfer G,Wernsdorfer WH

更新日期：2002-01-01 00:00:00

abstract：:The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with r...

journal_title：Antimicrobial agents and chemotherapy

authors： Furi L,Ciusa ML,Knight D,Di Lorenzo V,Tocci N,Cirasola D,Aragones L,Coelho JR,Freitas AT,Marchi E,Moce L,Visa P,Northwood JB,Viti C,Borghi E,Orefici G,BIOHYPO Consortium.,Morrissey I,Oggioni MR

更新日期：2013-08-01 00:00:00

abstract：:Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA). Additionally, linezolid shows an immunomodulatory effect, such as inhibition of inflammatory cytokine production. In this study, we examined the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaku N,Yanagihara K,Morinaga Y,Yamada K,Harada Y,Migiyama Y,Nagaoka K,Nakamura S,Izumikawa K,Kohno S

更新日期：2014-07-01 00:00:00

abstract：:Gatifloxacin is an 8-methoxy fluoroquinolone effective against a broad spectrum of pathogens common in pediatric infections. The safety and pharmacokinetics of a single dose of gatifloxacin were studied in pediatric patients from 6 months to 16 years of age. Seventy-six pediatric patients (average age, 6.7 +/- 5.0 yea...

journal_title：Antimicrobial agents and chemotherapy

authors： Capparelli EV,Reed MD,Bradley JS,Kearns GL,Jacobs RF,Damle BD,Blumer JL,Grasela DM

更新日期：2005-03-01 00:00:00

abstract：:Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DCK,Guo I,Burrows LL

更新日期：2020-02-21 00:00:00

abstract：:While Candida albicans remains the most common Candida isolate, Candida glabrata accounts for approximately 15 to 20% of all Candida infections in the United States. In this study we used immunosuppressed mice infected with C. glabrata to investigate the efficacy of liposomal amphotericin B alone or in combination wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Olson JA,Adler-Moore JP,Smith PJ,Proffitt RT

更新日期：2005-12-01 00:00:00

abstract：:The biliary excretion of moxalactam was studied in 11 postsurgery patients who had indwelling T-tubes inserted in their common bile ducts. Peak levels of moxalactam in the bile reached mean levels of 33.7 +/- 11.1 and 173.7 +/- 67.0 micrograms/ml 2 h after intravenous administration of a single 500- or 2,000-mg dose, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez OV,Levi JU,Livingstone A,Malinin TI,Zeppa R,Hutson D,Einhorn N

更新日期：1981-08-01 00:00:00

abstract：:A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 50% inhibitory conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Severin A,Chopra R,Krishnamurthy G,Singh G,Hu W,Keeney D,Svenson K,Petersen PJ,Labthavikul P,Shlaes DM,Rasmussen BA,Failli AA,Shumsky JS,Kutterer KM,Gilbert A,Mansour TS

更新日期：2006-02-01 00:00:00

abstract：:Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

journal_title：Antimicrobial agents and chemotherapy

authors： Lau AH,Chang CW,Sabatini S

更新日期：1986-02-01 00:00:00

abstract：:There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration of daptomycin in patients with suspected or documented neurosurgical infections. We conducted a prospective study, assessing the pharmacokinetics and CSF penetration of a single intravenous daptomycin dose administered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kullar R,Chin JN,Edwards DJ,Parker D,Coplin WM,Rybak MJ

更新日期：2011-07-01 00:00:00

abstract：:A method utilizing immobilized major group rhinoviruses and biotinylated soluble intercellular adhesion molecule 1 has been developed for the detection of capsid binders. Binding measurements indicate a loss in relative affinity of biotinylated soluble intercellular adhesion molecule 1 for rhinoviruses by capsid binde...

journal_title：Antimicrobial agents and chemotherapy

authors： Last-Barney K,Marlin SD,Pal K,Cahill-Feehan C,McNally EJ,Jeanfavre DD,Merluzzi VJ

更新日期：1993-08-01 00:00:00