Comparison of the clinical characteristics and outcomes associated with vancomycin-resistant Enterococcus faecalis and vancomycin-resistant E. faecium bacteremia.

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:Three mer transposons from the Murray collection of preantibiotic enterobacteria show >99% sequence identity to current isolates. Tn5073 is most closely related to Tn5036 and Tn1696, and Tn5074 is most closely related to Tn5053. Tn5075 is most closely related to Tn21 but lacks integron In2 and is flanked by insertion ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essa AM,Julian DJ,Kidd SP,Brown NL,Hobman JL

更新日期：2003-03-01 00:00:00

abstract：:One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan CS,Morgan SL,Jordan AB,Smith CW,Sutton JP,Gangemi JD

更新日期：1984-01-01 00:00:00

abstract：:We have cloned a 4.9-kilobase (kb) HincII fragment which contains a tetracycline resistance determinant (tetM) from the chromosome of Ureaplasma urealyticum. The 4.9-kb HincII fragment contains DNA in addition to the structural gene, is closely related to the previously characterized 5.0-kb fragment from pJI3, and con...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown JT,Roberts MC

更新日期：1987-11-01 00:00:00

abstract：:Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-dir...

journal_title：Antimicrobial agents and chemotherapy

authors： Krief S,Martin MT,Grellier P,Kasenene J,Sévenet T

更新日期：2004-08-01 00:00:00

abstract：:Leukocyte chemotaxis was inhibited 9.6% compared with control in the presence of 10 mug of gentamicin per ml and 10.5% when exposed to 20 mug of amikacin per ml. However, cells incubated with an injectable form of gentamicin, containing preservatives, were inhibited an additional 25.8% relative to cells incubated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodhart GL

更新日期：1977-10-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating t...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Martínez L,Pascual A,Hernández-Allés S,Alvarez-Díaz D,Suárez AI,Tran J,Benedí VJ,Jacoby GA

更新日期：1999-07-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Escherichia coli is an important pathogen that shows increasing antimicrobial resistance in isolates from both animals and humans. Our laboratory recently described Salmonella isolates from food animals and humans that expressed an identical plasmid-mediated, AmpC-like beta-lactamase, CMY-2. In the present study, 59 o...

journal_title：Antimicrobial agents and chemotherapy

authors： Winokur PL,Vonstein DL,Hoffman LJ,Uhlenhopp EK,Doern GV

更新日期：2001-10-01 00:00:00

abstract：:Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucher LA,Chen YM,Walker JB

更新日期：1989-04-01 00:00:00

abstract：:We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pultz NJ,Stiefel U,Ghannoum M,Helfand MS,Donskey CJ

更新日期：2005-01-01 00:00:00

abstract：:As part of the SENTRY Antimicrobial Surveillance Program in 2002, five multidrug-resistant Pseudomonas aeruginosa clinical isolates were detected with metallo-beta-lactamase (MbetaL) activity. The isolates were recovered from different patients in a medical center located in Dusseldorf, Germany. The resistant determin...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Toleman MA,Jones RN,Schmidt FJ,Walsh TR

更新日期：2004-12-01 00:00:00

abstract：:The increasing incidence and severity of infection by Clostridium difficile have stimulated attempts to develop new antimicrobial therapies. We report here the relative abilities of two antibiotics (metronidazole and vancomycin) in current use for treating C. difficile infection and of a third antimicrobial, surotomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bouillaut L,McBride S,Sorg JA,Schmidt DJ,Suarez JM,Tzipori S,Mascio C,Chesnel L,Sonenshein AL

更新日期：2015-07-01 00:00:00

abstract：:Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of w...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Y,Creek D,Chollet J,Matile H,Charman SA,Wittlin S,Wood JK,Vennerstrom JL

更新日期：2007-08-01 00:00:00

abstract：:The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Logan M,Cooper M,Ashby JP,Andrews JM

更新日期：1990-08-01 00:00:00

abstract：:One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention. A total of 9 of 78 Ch-P-treated subjects and 26 of 52 subjects who received no prophylaxis contra...

journal_title：Antimicrobial agents and chemotherapy

authors： Gozal D,Hengy C,Fadat G

更新日期：1991-02-01 00:00:00

abstract：:Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kid...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Donnell JN,Rhodes NJ,Lodise TP,Prozialeck WC,Miglis CM,Joshi MD,Venkatesan N,Pais G,Cluff C,Lamar PC,Briyal S,Day JZ,Gulati A,Scheetz MH

更新日期：2017-10-24 00:00:00

abstract：:The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae. For clarithromycin the MIC at which 90% of the isolates were inhibited was

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Catamo G,Di Bonaventura G

更新日期：1998-11-01 00:00:00

abstract：:The aim of this study was to characterize a novel extended-spectrum beta-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine residue at posi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Celenza G,De Santis F,Pellegrini C,Forcella C,Rossolini GM,Stefani S,Amicosante G

更新日期：2008-03-01 00:00:00

abstract：:Several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant Staphylococcus aureus MI339 and vancomycin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Zervosen A,Lu WP,Chen Z,White RE,Demuth TP Jr,Frère JM

更新日期：2004-03-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:The structure-activity relations of myxinidin, a peptide derived from epidermal mucus of hagfish, Myxine glutinosa L., were investigated. Analysis of key residues allowed us to design new peptides with increased efficiency. Antimicrobial activity of native and modified peptides demonstrated the key role of uncharged r...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantisani M,Leone M,Mignogna E,Kampanaraki K,Falanga A,Morelli G,Galdiero M,Galdiero S

更新日期：2013-11-01 00:00:00

abstract：:Filibuvir and VX-222 are nonnucleoside inhibitors (NNIs) that bind to the thumb II allosteric pocket of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. Both compounds have shown significant promise in clinical trials and, therefore, it is relevant to better understand their mechanisms of inhibition. In our s...

journal_title：Antimicrobial agents and chemotherapy

authors： Yi G,Deval J,Fan B,Cai H,Soulard C,Ranjith-Kumar CT,Smith DB,Blatt L,Beigelman L,Kao CC

更新日期：2012-02-01 00:00:00

abstract：:The antiviral activity of zinc salts against rhinovirus types 1A and 39 was assayed by yield reduction and inhibition of cytopathic effect in cell culture. The findings indicate that the zinc salts tested have low in vitro therapeutic indices and suggest that the possible beneficial effects of zinc lozenges in reducin...

journal_title：Antimicrobial agents and chemotherapy

authors： Geist FC,Bateman JA,Hayden FG

更新日期：1987-04-01 00:00:00

abstract：:Since human cytomegalovirus (HCMV) does not infect or replicate in nonhuman cells and tissues, there are few animal models currently available for evaluation of antiviral therapies for these infections. In the present studies, we utilized two different models in which severe combined immunodeficient (SCID) mice were i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline CB,Rybak RJ,Drach JC,Townsend LB,Biron KK,Bidanset DJ

更新日期：2004-05-01 00:00:00

abstract：:Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong K,Su C,Sun Q,Lu Y

更新日期：2021-01-20 00:00:00

abstract：:Few studies have estimated the excess inpatient costs due to nosocomial cultures of Gram-negative bacteria (GNB), and those that do are often subject to time-dependent bias. Our objective was to generate estimates of the attributable costs of the underlying infections associated with nosocomial cultures by using a uni...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RE,Stevens VW,Jones M,Khader K,Schweizer ML,Perencevich EN,Rubin MA,Samore MH

更新日期：2018-10-24 00:00:00

abstract：:New antibiotics are required to have the antibacterial activity against doxycycline-resistant Orientia tsutsugamushi. An in vitro sensitivity study showed that telithromycin was more effective than erythromycin for Rickettsia, Bartonella, and Coxiella burnetii. In this prospective, open-label, randomized trial, we enr...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim DM,Yu KD,Lee JH,Kim HK,Lee SH

更新日期：2007-06-01 00:00:00