Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda.

Abstract:

:Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.

authors

Krief S,Martin MT,Grellier P,Kasenene J,Sévenet T

doi

10.1128/AAC.48.8.3196-3199.2004

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

3196-9

issue

8

eissn

0066-4804

issn

1098-6596

pii

48/8/3196

journal_volume

48

pub_type

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