Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda.


:Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.


Krief S,Martin MT,Grellier P,Kasenene J,Sévenet T




Has Abstract


2004-08-01 00:00:00














  • Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in Enterobacter cloacae.

    abstract::Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pérez A,Poza M,Aranda J,Latasa C,Medrano FJ,Tomás M,Romero A,Lasa I,Bou G

    更新日期:2012-12-01 00:00:00

  • The Race To Find Antivirals for Zika Virus.

    abstract::Zika virus (ZIKV), a flavivirus transmitted by mosquitoes, was an almost neglected pathogen until its introduction in the Americas in 2015 and its subsequent explosive spread throughout the continent, where it has infected millions of people. The virus has caused social and sanitary alarm, mainly due to its associatio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,评审


    authors: Saiz JC,Martín-Acebes MA

    更新日期:2017-05-24 00:00:00

  • Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes.

    abstract::Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug Administration. In...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Maga G,Ubiali D,Salvetti R,Pregnolato M,Spadari S

    更新日期:2000-05-01 00:00:00

  • Outbreak caused by Enterobacteriaceae harboring NDM-1 metallo-β-lactamase carried in an IncFII plasmid in a tertiary care hospital in Mexico City.

    abstract::Carbapenem-resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase 1 (NDM-1) have rarely been reported in Latin America. We report of an outbreak caused by a blaNDM-1-harboring plasmid spread through different bacterial species, including Escherichia coli (ST617) and Enterobacter cloacae (ST182) isolates f...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Torres-González P,Bobadilla-Del Valle M,Tovar-Calderón E,Leal-Vega F,Hernández-Cruz A,Martínez-Gamboa A,Niembro-Ortega MD,Sifuentes-Osornio J,Ponce-de-León A

    更新日期:2015-11-01 00:00:00

  • Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans.

    abstract::The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

    更新日期:2002-12-01 00:00:00

  • TEM-24 produced by four different species of Enterobacteriaceae, including Providencia rettgeri, in a single patient.

    abstract::Four species of members of the family Enterobacteriaceae harboring extended-spectrum beta-lactamase (ESBL) were recovered in a single patient hospitalized in an intensive care unit. Among these isolates, we describe for the first time an ESBL-producing Providencia rettgeri strain. Bacteria from the same species were s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Marchandin H,Carriere C,Sirot D,Pierre HJ,Darbas H

    更新日期:1999-08-01 00:00:00

  • Comparative in vitro studies of nalidixic acid, oxolinic acid, and a new analog with thieno (2,3-b) pyridine structure.

    abstract::Bacterial susceptibility to a new organic acid related to nalidixic acid and oxolinic acid was tested. The in vitro susceptibility pattern of the new compound was found to be very similar to that of nalidixic acid. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gilis PM,Haemers A,Pattyn SR

    更新日期:1978-03-01 00:00:00

  • In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs.

    abstract::Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ruiz-Serrano MJ,Alcalá L,Martínez L,Díaz M,Marín M,González-Abad MJ,Bouza E

    更新日期:2000-09-01 00:00:00

  • A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors.

    abstract::It was previously found that certain nonnucleoside reverse transcriptase inhibitors (NNRTI) possess virucidal activity against human immunodeficiency virus type 1 (HIV-1), and it was suggested that the tight-binding mode of inhibition of reverse transcriptase might be important for this virucidal activity (Borkow et a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Motakis D,Parniak MA

    更新日期:2002-06-01 00:00:00

  • Comparative activities of Bay n7133, ICI 153,066, and ketoconazole in murine cryptococcosis.

    abstract::Two new antifungal triazoles, BAY n7133 and ICI 153,066, were compared with ketoconazole in treatment of mice challenged intraperitoneally with Cryptococcus neoformans. At high challenge doses, thymus-containing normal mice had prolonged survival after treatment with BAY n7133. Athymic mice, which have severely defici...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Graybill JR,Kaster SR,Drutz DJ

    更新日期:1983-12-01 00:00:00

  • Disposition of intravenous pyrimethamine in healthy volunteers.

    abstract::A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

    更新日期:2000-06-01 00:00:00

  • Enhanced phagocytosis of encapsulated Escherichia coli strains after exposure to sub-MICs of antibiotics is correlated to changes of the bacterial cell surface.

    abstract::The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Raponi G,Keller N,Overbeek BP,Rozenberg-Arska M,van Kessel KP,Verhoef J

    更新日期:1990-02-01 00:00:00

  • In vitro acquisition of secondary azole resistance in Aspergillus fumigatus isolates after prolonged exposure to itraconazole: presence of heteroresistant populations.

    abstract::Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Escribano P,Recio S,Peláez T,González-Rivera M,Bouza E,Guinea J

    更新日期:2012-01-01 00:00:00

  • Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro.

    abstract::BILN 2061 is a novel, specific hepatitis C virus (HCV) NS3 serine protease inhibitor discovered by Boehringer Ingelheim that has shown potent activity against HCV replicons in tissue culture and is currently under clinical investigation for the treatment of HCV infection. The poor fidelity of the HCV RNA-dependent RNA...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lu L,Pilot-Matias TJ,Stewart KD,Randolph JT,Pithawalla R,He W,Huang PP,Klein LL,Mo H,Molla A

    更新日期:2004-06-01 00:00:00

  • Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs.

    abstract::The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 30 to 500 nM; these ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zhang Y,Meshnick SR

    更新日期:1991-02-01 00:00:00

  • Simple technique for the assay of antibiotic synergism against enterococci.

    abstract::A simple technique with antibiotic-impregnated disks has been developed to demonstrate the antibiotic synergism of penicillins and aminoglycosides against enterococci. The two antibiotic disks are placed on inoculated plates so that the distance between their centers is less than the sum of the two radii of their prev...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lee WS,Komarmy L

    更新日期:1975-01-01 00:00:00

  • Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone.

    abstract::The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Spector SA,Ripley D,Hsia K

    更新日期:1989-06-01 00:00:00

  • Chloramphenicol pharmacokinetics in hospitalized patients.

    abstract::The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Koup JR,Lau AH,Brodsky B,Slaughter RL

    更新日期:1979-05-01 00:00:00

  • Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii.

    abstract::In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Srinivasan VB,Rajamohan G,Gebreyes WA

    更新日期:2009-12-01 00:00:00

  • In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model.

    abstract::Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

    更新日期:2020-01-27 00:00:00

  • Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.

    abstract::Dengue virus (DENV) causes disease globally, with an estimated 25 to 100 million new infections per year. At present, no effective vaccine is available, and treatment is supportive. In this study, we identified BP2109, a potent and selective small-molecule inhibitor of the DENV NS2B/NS3 protease, by a high-throughput ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yang CC,Hsieh YC,Lee SJ,Wu SH,Liao CL,Tsao CH,Chao YS,Chern JH,Wu CP,Yueh A

    更新日期:2011-01-01 00:00:00

  • Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors.

    abstract::The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by eit...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mishin VP,Hayden FG,Gubareva LV

    更新日期:2005-11-01 00:00:00

  • Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.

    abstract::Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation. Mo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lun S,Tasneen R,Chaira T,Stec J,Onajole OK,Yang TJ,Cooper CB,Mdluli K,Converse PJ,Nuermberger EL,Raj VS,Kozikowski A,Bishai WR

    更新日期:2019-06-24 00:00:00

  • Penetration of aztreonam into human bronchial secretions.

    abstract::Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

    更新日期:1985-02-01 00:00:00

  • Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.

    abstract::Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against sm...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vermot D,Entenza JM,Vouillamoz J,Glauser MP,Moreillon P

    更新日期:1996-03-01 00:00:00

  • Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis.

    abstract::Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

    更新日期:2015-07-01 00:00:00

  • Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice.

    abstract::The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate in the parenteral treatment of systemic herpes simplex virus type 1 infections in Swiss mice were determined. Among cont...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shannon WM,Westbrook L,Arnett G,Daluge S,Lee H,Vince R

    更新日期:1983-10-01 00:00:00

  • Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network.

    abstract::Carbapenem resistance in Gram-negative bacteria is on the rise in the United States. A regional network was established to study microbiological and genetic determinants of clinical outcomes in hospitalized patients with carbapenem-resistant (CR) Klebsiella pneumoniae in a prospective, multicenter, observational study...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: van Duin D,Perez F,Rudin SD,Cober E,Hanrahan J,Ziegler J,Webber R,Fox J,Mason P,Richter SS,Cline M,Hall GS,Kaye KS,Jacobs MR,Kalayjian RC,Salata RA,Segre JA,Conlan S,Evans S,Fowler VG Jr,Bonomo RA

    更新日期:2014-07-01 00:00:00

  • Antibacterial activity of niridazole against Salmonellae.

    abstract::Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bannatyne RM,Jackowski J,Grant RB

    更新日期:1986-05-01 00:00:00

  • In vitro evaluation of nicotinamide riboside analogs against Haemophilus influenzae.

    abstract::Exogenous NAD, nicotinamide mononucleotide, or nicotinamide riboside is required for the growth of Haemophilus influenzae. These compounds have been defined as the V-factor growth requirement. We have previously shown that the internalization of nicotinamide riboside is energy dependent and carrier mediated with satur...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Godek CP,Cynamon MH

    更新日期:1990-08-01 00:00:00