Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans.

abstract：:Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel HD,Nikitin P,Gesner T,Lin JJ,Barkan DT,Ciferri C,Carfi A,Akbarnejad Yazdi T,Skewes-Cox P,Wiedmann B,Jarousse N,Zhong W,Feire A,Hebner CM

更新日期：2016-07-22 00:00:00

abstract：:Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vignaroli C,Biavasco F,Varaldo PE

更新日期：2006-07-01 00:00:00

abstract：:Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of penicillin, ampicillin, cefoxitin, and cefuroxime were determined for 103 beta-lactamase-negative Neisseria gonorrhoeae clinical isolates belonging to five different auxotypes. MBC determinations were base on killing 99.9% of th...

journal_title：Antimicrobial agents and chemotherapy

authors： de Repentigny L,Turgeon PL

更新日期：1981-04-01 00:00:00

abstract：:With the emergence of multidrug-resistant mycobacterial strains, better therapeutic strategies are required for the successful treatment of the infection. Although antimicrobial peptides (AMPs) and silver nanoparticles (AgNPs) are becoming one of the popular antibacterial agents, their antimycobacterial potential is n...

journal_title：Antimicrobial agents and chemotherapy

authors： Mohanty S,Jena P,Mehta R,Pati R,Banerjee B,Patil S,Sonawane A

更新日期：2013-08-01 00:00:00

abstract：:Within wounds, microorganisms predominantly exist as biofilms. Biofilms are associated with chronic infections and represent a tremendous clinical challenge. As antibiotics are often ineffective against biofilms, use of dispersal agents as adjunctive, topical therapies for the treatment of wound infections involving b...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanchez CJ Jr,Akers KS,Romano DR,Woodbury RL,Hardy SK,Murray CK,Wenke JC

更新日期：2014-08-01 00:00:00

abstract：:Biofilm production is an important step in the pathogenesis of Staphylococcus epidermidis polymer-associated infections and depends on the expression of the icaADBC operon leading to the synthesis of a polysaccharide intercellular adhesin. A chromosomally encoded reporter gene fusion between the ica promoter and the b...

journal_title：Antimicrobial agents and chemotherapy

authors： Rachid S,Ohlsen K,Witte W,Hacker J,Ziebuhr W

更新日期：2000-12-01 00:00:00

abstract：:The in vitro activities of 25 quinolones and fluoroquinolones against erythrocytic stages of Plasmodium falciparum and against liver stages of Plasmodium yoelii yoelii and P. falciparum were studied. All compounds were inhibitory for chloroquine-sensitive and chloroquine-resistant P. falciparum grown in red blood cell...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahmoudi N,Ciceron L,Franetich JF,Farhati K,Silvie O,Eling W,Sauerwein R,Danis M,Mazier D,Derouin F

更新日期：2003-08-01 00:00:00

abstract：:Miloxacin, a synthetic antibacterial agent structurally related to oxolinic acid, has a broad spectrum of activity in vitro against gram-negative bacteria and considerable activity in vivo against infections with these bacteria. These observations led to studies on the absorption and excretion of miloxacin in mice, ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Izawa A,Yoshitake A,Komatsu T

更新日期：1980-07-01 00:00:00

abstract：:The emergence of resistance to antimicrobial agents within the salmonellas is a worldwide and severe problem. A case of treatment failure due to the emergence of resistance to ceftriaxone in Salmonella enterica serotype Anatum was studied. S. enterica serotype Anatum and Escherichia coli, both of which are susceptible...

journal_title：Antimicrobial agents and chemotherapy

authors： Su LH,Chiu CH,Chu C,Wang MH,Chia JH,Wu TL

更新日期：2003-02-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:An increase in the number of tuberculosis cases caused by multiple-drug-resistant strains of Mycobacterium tuberculosis has stimulated search for new antituberculous agents. Beta-lactam antibiotics, traditionally regarded as ineffective against tuberculosis, merit consideration. Four major penicillin-binding proteins ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Moreau D,Yajko D,Miick C,Wagner C,Hackbarth C,Kocagöz S,Rosenberg E,Hadley WK,Nikaido H

更新日期：1995-12-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, causing over 200,000 deaths a year. NoV is nonenveloped, with a single-stranded RNA genome, and is primarily transmitted person to person. The viral RNA-dependent RNA polymerase (RdRp) is critical for the production of genomic and subgenomic RNA ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eltahla AA,Lim KL,Eden JS,Kelly AG,Mackenzie JM,White PA

更新日期：2014-06-01 00:00:00

abstract：:In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of beta-lactamase genes and ftsI gene mutations. For all isolates, the minimal co...

journal_title：Antimicrobial agents and chemotherapy

authors： Kishii K,Chiba N,Morozumi M,Ono A,Ida T,Ubukata K

更新日期：2010-09-01 00:00:00

abstract：:This analysis of nearly 10,000 hospital-associated urinary tract infection (UTI) episodes due to Escherichia coli showed that fluoroquinolone and third-generation-cephalosporin resistance rates were 34.5% and 8.6%, respectively; the rate of concurrent resistance to both agents was 7.3%. Fluoroquinolone resistance rate...

journal_title：Antimicrobial agents and chemotherapy

authors： Bidell MR,Palchak M,Mohr J,Lodise TP

更新日期：2016-04-22 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used intravenous antibiotic for the empirical treatment of infection in intensive care patients, including burn patients. The purpose of this study was to develop a population pharmacokinetic (PK) model for piperacillin in burn patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeon S,Han S,Lee J,Hong T,Paek J,Woo H,Yim DS

更新日期：2014-07-01 00:00:00

abstract：:Streptococcus agalactiae (group B Streptococcus [GBS]) is a Gram-positive bacterium that colonizes the cervicovaginal tract in approximately 25% of healthy women. Although colonization is asymptomatic, GBS can be vertically transmitted to newborns peripartum, causing severe disease such as pneumonia and meningitis. Cu...

journal_title：Antimicrobial agents and chemotherapy

authors： Cavaco CK,Patras KA,Zlamal JE,Thoman ML,Morgan EL,Sanderson SD,Doran KS

更新日期：2013-11-01 00:00:00

abstract：:The comparative activities of azithromycin (AZI) and clarithromycin (CLA) against eight Mycobacterium avium complex (MAC) isolates were evaluated in the beige mouse model of disseminated infection. Mice were infected intravenously with approximately 10(7) viable MAC isolate. AZI at 100 or 200 mg/kg of body weight or C...

journal_title：Antimicrobial agents and chemotherapy

authors： Cynamon MH,Klemens SP,Grossi MA

更新日期：1994-07-01 00:00:00

abstract：:A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Cuchural GJ Jr,Jacobus NV,Gorbach SL,Aldridge K,Cleary T,Finegold SM,Hill G,Iannini P,O'Keefe JP

更新日期：1985-11-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00

abstract：:Although it is generally believed that bactericidal and bacteriostatic drugs should not be combined in vivo, in vitro experiments using the checkerboard dilution technique revealed no antagonism between penicillin/cephalothin and rolitetracycline but rather additive or synergistic activity of either drug combination i...

journal_title：Antimicrobial agents and chemotherapy

authors： Daschner FD

更新日期：1976-11-01 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococca...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MS,Chai Y,Britigan BE,McKenna W,Adams J,Svendsen T,Bean K,Hassett DJ,Sparling PF

更新日期：1987-10-01 00:00:00

abstract：:Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapen...

journal_title：Antimicrobial agents and chemotherapy

authors： Egelund EF,Weiner M,Singh RP,Prihoda TJ,Gelfond JA,Derendorf H,Mac Kenzie WR,Peloquin CA

更新日期：2014-08-01 00:00:00

abstract：:Bacterial susceptibility to a new organic acid related to nalidixic acid and oxolinic acid was tested. The in vitro susceptibility pattern of the new compound was found to be very similar to that of nalidixic acid. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gilis PM,Haemers A,Pattyn SR

更新日期：1978-03-01 00:00:00

abstract：:Mefloquine was found to have bactericidal activity against methicillin- and fluoroquinolone-susceptible and -resistant strains of Staphylococcus aureus and Staphylococcus epidermidis and gentamicin- and vancomycin-resistant strains of Enterococcus faecalis and Enterococcus faecium. The MICs were 16 microg/ml, and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kunin CM,Ellis WY

更新日期：2000-04-01 00:00:00

abstract：:The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of common aerobic gram-positive and anaerobic organisms was determined. MDL 62,879 was highly active against staphylococci (MI...

journal_title：Antimicrobial agents and chemotherapy

authors： King A,Bethune L,Phillips I

更新日期：1993-04-01 00:00:00

abstract：:Wastewater is considered a major source of antibiotic-resistant bacteria released into the environment. Here, we characterized carbapenemase-producing Enterobacteriaceae (CPE) in wastewater by whole-genome analysis. Wastewater samples (n = 40) were collected from municipal wastewater treatment plants and hospital wast...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomi R,Matsuda T,Yamamoto M,Chou PH,Tanaka M,Ichiyama S,Yoneda M,Matsumura Y

更新日期：2018-04-26 00:00:00

abstract：:The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

更新日期：2014-01-01 00:00:00