In vivo acquisition of ceftriaxone resistance in Salmonella enterica serotype anatum.

abstract：:The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic biosynthesis gene cluster. Addition of pgaF to a gene cassette that harbored the early biosynthesis genes of nogalamycin re...

journal_title：Antimicrobial agents and chemotherapy

authors： Metsä-Ketelä M,Palmu K,Kunnari T,Ylihonko K,Mäntsälä P

更新日期：2003-04-01 00:00:00

abstract：:The telithromycin susceptibility of 210 erythromycin-resistant pneumococci was tested with the agar diffusion method. Twenty-six erm(B)-positive isolates showed heterogeneous resistance to telithromycin, which was manifested by the presence of colonies inside the inhibition zone. When these cells were cultured and tes...

journal_title：Antimicrobial agents and chemotherapy

authors： Rantala M,Haanperä-Heikkinen M,Lindgren M,Seppälä H,Huovinen P,Jalava J

更新日期：2006-05-01 00:00:00

abstract：:beta-Lactam antibiotics are extremely effective in disrupting the synthesis of the bacterial cell wall in both gram-positive and gram-negative bacteria. However, they are ineffective against Mycobacterium tuberculosis, due to the production of a beta-lactamase enzyme encoded on the chromosome of M. tuberculosis that d...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang F,Cassidy C,Sacchettini JC

更新日期：2006-08-01 00:00:00

abstract：:With the growing global threat of antimicrobial resistance, novel strategies are required for combatting resistant pathogens. Combination therapy, in which multiple drugs are used to treat an infection, has proven highly successful in the treatment of cancer and HIV. However, this practice has proven challenging for t...

journal_title：Antimicrobial agents and chemotherapy

authors： Adamowicz EM,Harcombe WR

更新日期：2020-10-20 00:00:00

abstract：:This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance in constitutively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Bacciaglia A,Vecchi M,Vitali LA,Varaldo PE,Giovanetti E

更新日期：2007-04-01 00:00:00

abstract：:The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoureaux TL,Frase H,Antunes NT,Vakulenko SB

更新日期：2012-11-01 00:00:00

abstract：:Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but ...

journal_title：Antimicrobial agents and chemotherapy

authors： Long R,Jones R,Talbot J,Mayers I,Barrie J,Hoskinson M,Light B

更新日期：2005-03-01 00:00:00

abstract：:The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson P,Guarro J,Mayayo E,Capilla J

更新日期：2015-12-01 00:00:00

abstract：:Staphylococcus aureus bacteremia (SAB) causes high rates of morbidity and death. Several studies in academic health settings have demonstrated that consultations from infectious diseases specialists improve the quality of care and clinical outcomes for SAB. Few data that describe the impact in resource-limited setting...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Valcarlos E,Won R,Chang E,Schwartz J

更新日期：2016-09-23 00:00:00

abstract：:PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located in composite transposon Tn1213 made by two distinct insertion sequences, namely, ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the blaPER-1 gene, although at a ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Mancini S,Poirel L,Kieffer N,Nordmann P

更新日期：2018-02-23 00:00:00

abstract：:Since human cytomegalovirus (HCMV) does not infect or replicate in nonhuman cells and tissues, there are few animal models currently available for evaluation of antiviral therapies for these infections. In the present studies, we utilized two different models in which severe combined immunodeficient (SCID) mice were i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline CB,Rybak RJ,Drach JC,Townsend LB,Biron KK,Bidanset DJ

更新日期：2004-05-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-13...

journal_title：Antimicrobial agents and chemotherapy

authors： Prinarakis EE,Miriagou V,Tzelepi E,Gazouli M,Tzouvelekis LS

更新日期：1997-04-01 00:00:00

abstract：:The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in human...

journal_title：Antimicrobial agents and chemotherapy

authors： Imperi F,Massai F,Ramachandran Pillai C,Longo F,Zennaro E,Rampioni G,Visca P,Leoni L

更新日期：2013-02-01 00:00:00

abstract：:We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

更新日期：2017-04-24 00:00:00

abstract：:A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin, lomefloxacin, and sparfloxacin against gram-positive bacteria. A-80556 was particularly active against Staphylococcus aureus (MIC f...

journal_title：Antimicrobial agents and chemotherapy

authors： Clement JJ,Tanaka SK,Alder J,Vojtko C,Beyer J,Hensey D,Ramer N,McDaniel D,Chu DT

更新日期：1994-05-01 00:00:00

abstract：:The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline solution for 1 month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodzic E,Feng S,Holden K,Freet KJ,Barthold SW

更新日期：2008-05-01 00:00:00

abstract：:The purpose of this study was to assess the effect of voriconazole on the blood tacrolimus concentration in a liver transplant recipient and to examine the interaction between voriconazole and tacrolimus by using human liver microsomes. Two subjects were enrolled in the clinical study: one received voriconazole, and t...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkataramanan R,Zang S,Gayowski T,Singh N

更新日期：2002-09-01 00:00:00

abstract：:The site of localization of [(3)H]gentamicin within mouse kidney is shown to be the proximal renal tubule by coincidence of the radioactivity, as visualized by autoradiography, and the mucopolysaccharide-rich microvilli characteristic of proximal convoluted tubules, as visualized by histochemical staining. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuhar MJ,Mak LL,Lietman PS

更新日期：1979-01-01 00:00:00

abstract：:The transfer of DNA between Enterococcus faecium strains has been characterized both by the movement of well-defined genetic elements and by the large-scale transfer of genomic DNA fragments. In this work, we report on the whole-genome analysis of transconjugants resulting from mating events between the vancomycin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Solache M,Lebreton F,McLaughlin RE,Whiteaker JD,Gilmore MS,Rice LB

更新日期：2016-09-23 00:00:00

abstract：:Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases, this is catalyzed by flavin mononucleotide (FMN)-dependent type I nitroreductases (NTRs), a class of enzyme absent from higher eukaryotes but expressed by bacteria and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Seifert K,Helsby NA,Wilkinson SR

更新日期：2014-01-01 00:00:00

abstract：:Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycobacterium tuberculosis in in vitro and in vivo combination st...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Shoen CM,Jones SM,Jones PL,Cynamon MH,Locher CP

更新日期：2015-03-01 00:00:00

abstract：:Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA). Additionally, linezolid shows an immunomodulatory effect, such as inhibition of inflammatory cytokine production. In this study, we examined the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaku N,Yanagihara K,Morinaga Y,Yamada K,Harada Y,Migiyama Y,Nagaoka K,Nakamura S,Izumikawa K,Kohno S

更新日期：2014-07-01 00:00:00

abstract：:The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gordon RC,Regamey C,Kirby WM

更新日期：1972-09-01 00:00:00

abstract：:Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in use, including carbapenems. A total of 45,872 Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kazmierczak KM,Bradford PA,Stone GG,de Jonge BLM,Sahm DF

更新日期：2018-11-26 00:00:00

abstract：:Although fluoroquinolone antibiotics such as ciprofloxacin are able to gain access to lung tissue and both pleural and bronchial secretions, the characteristics of transport and cellular uptake of ciprofloxacin in human epithelial lung tissue remain obscure. We have chosen human airway epithelial (Calu-3) cells, recon...

journal_title：Antimicrobial agents and chemotherapy

authors： Cavet ME,West M,Simmons NL

更新日期：1997-12-01 00:00:00

abstract：:This study sought to characterize the impact of 3 types of variation on the Standardized Antimicrobial Administration Ratio (SAAR) utilizing local National Healthcare Safety Network (NHSN) data. SAAR and antimicrobial days per 1,000 days present (AD/1000DP) were compiled monthly for Northwestern Memorial Hospital from...

journal_title：Antimicrobial agents and chemotherapy

authors： Avedissian SN,Rhodes NJ,Liu J,Aljefri D,Postelnick MJ,Sutton SH,Zembower TR,Martin D,Pais G,Cruce CE,Scheetz MH

更新日期：2019-02-26 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00

abstract：:Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin serotype A. This fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,McKenzie R,Fuchs EJ,Jurao RA,An AT,Ahene A,Tomic M,Hendrix CW,Zenilman JM

更新日期：2014-09-01 00:00:00

abstract：:Clostridium difficile is the most frequently identified enteric pathogen in patients with nosocomially acquired, antibiotic-associated diarrhea. The drugs most commonly used to treat diseases associated with C. difficile are metronidazole and vancomycin. Most clinical laboratories assume that all C. difficile isolates...

journal_title：Antimicrobial agents and chemotherapy

authors： Peláez T,Alcalá L,Alonso R,Rodríguez-Créixems M,García-Lechuz JM,Bouza E

更新日期：2002-06-01 00:00:00