Autoradiographic localization of [3H]gentamicin in the proximal renal tubules of mice.

abstract：:Pefloxacin has been shown to have good intraocular penetration when given systemically. In order to extend its clinical use, we have assessed the tolerability, kinetics, and efficacy of subconjunctival pefloxacin in phakic pigmented rabbits. The tolerability of a single subconjunctival injection of pefloxacin (0.8, 1....

journal_title：Antimicrobial agents and chemotherapy

authors： Marrakchi-Benjaafar S,Cochereau I,D'Hermies F,Pocidalo JJ

更新日期：1995-04-01 00:00:00

abstract：:Mycobacterium abscessus is a major nontuberculous mycobacterial (NTM) pathogen and is responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against M. abscessus, but the mechanism of resistance to clofazimine in M. abscessus is unknown. To...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Chen J,Zhang S,Shi W,Zhang W,Zhu M,Zhang Y

更新日期：2018-06-26 00:00:00

abstract：:Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and a disk diffusion method. PCR was used to test drug-resistant genes, and the χ(2) test and definite probability methods were used to test for statistically significant differences among the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yin J,Yu S,Liu X,Li Y,Gao W,Ma X,Yang Y

更新日期：2011-01-01 00:00:00

abstract：:Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described for extremely preterm neonates but have been poorly described for late-preterm and term neonates. Thus, evidence-based dosing recommendations are lacking. We describe th...

journal_title：Antimicrobial agents and chemotherapy

authors： Padari H,Metsvaht T,Germovsek E,Barker CI,Kipper K,Herodes K,Standing JF,Oselin K,Tasa T,Soeorg H,Lutsar I

更新日期：2018-04-26 00:00:00

abstract：:Plasmid-mediated mechanisms, comprising TEM hyperproduction, TEM derivative production, and OXA production, lead to amoxicillin-clavulanic acid resistance in enterobacteria. The ability of the single-strand conformation polymorphism (SSCP)-PCR method to differentiate the genes encoding inhibitor-resistant beta-lactama...

journal_title：Antimicrobial agents and chemotherapy

authors： Speldooren V,Heym B,Labia R,Nicolas-Chanoine MH

更新日期：1998-04-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new assay system in agar plates, the radial diffusion assay, to evaluate the effects of human defensins against gram-positive...

journal_title：Antimicrobial agents and chemotherapy

authors： Takemura H,Kaku M,Kohno S,Hirakata Y,Tanaka H,Yoshida R,Tomono K,Koga H,Wada A,Hirayama T,Kamihira S

更新日期：1996-10-01 00:00:00

abstract：:The effects of cefodizime and cefuroxime on neutrophil phagocytosis and reactive oxygen production in 54 patients undergoing elective coronary artery bypass grafting were studied. Both drugs were administered twice at a dosage of 40 mg/kg of body weight (pre- and intraoperative). Phagocytic capacity was assessed by me...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch C,Bartunek A,Zedtwitz-Liebenstein K,Hiesmayr M,Parschalk B,Pernerstorfer T,Graninger W

更新日期：1997-07-01 00:00:00

abstract：:Mycobacteroides abscessus (Mab) is an opportunistic environmental pathogen that can cause chronic pulmonary disease in the setting of structural lung conditions such as bronchiectasis, COPD and cystic fibrosis. These infections are often incurable and associated with rapid lung function decline. Mab is naturally resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Story-Roller E,Galanis C,Lamichhane G

更新日期：2020-12-23 00:00:00

abstract：:The pharmacodynamic effects of metronidazole on Trichomonas vaginalis have been poorly characterized. The present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). Five laboratory strains and five...

journal_title：Antimicrobial agents and chemotherapy

authors： Nix DE,Tyrrell R,Müller M

更新日期：1995-08-01 00:00:00

abstract：:The mechanism(s) of daptomycin (DAP) resistance (DAPr) is incompletely defined. Thickened cell walls (CWs) acting as either a mechanical barrier or an affinity trap for DAP have been purported to be a major contributor to the DAPr phenotype. To this end, we studied an isogenic set of methicillin-resistant Staphylococc...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang SJ,Nast CC,Mishra NN,Yeaman MR,Fey PD,Bayer AS

更新日期：2010-08-01 00:00:00

abstract：:The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of li...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Spyridaki I,Scoulica E,Psaroulaki A,Tselentis Y

更新日期：2001-11-01 00:00:00

abstract：:The penam nucleus can assume two conformations; these are designated open and closed. The synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. It has been shown that the beta-methylenepenams are essentially inactive, suggesting that the cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Christenson JG,Pruess DL,Talbot MK,Keith DD

更新日期：1988-07-01 00:00:00

abstract：:The effectiveness of Staphylococcus aureus strain 8325-4 as a recipient for the transduction of methicillin resistance requires the presence of a penicillinase plasmid but was found to be independent of the lysogenic state of the recipient. Effectiveness is conferred by the plasmid in either the autonomous or integrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Stewart GC,Rosenblum ED

更新日期：1980-09-01 00:00:00

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

journal_title：Antimicrobial agents and chemotherapy

authors： Ho II,Chan CY,Cheng AF

更新日期：2000-01-01 00:00:00

abstract：:Biochemical variations accompanying the acquisition of ethambutol (EMB) resistance in a single-step mutant of Mycobacterium tuberculosis H37Ra were analyzed. Comparative analysis of phospholipids revealed a reduced content in the EMB-resistant strain, particularly in the cell membrane fraction. Significant alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Sareen M,Khuller GK

更新日期：1990-09-01 00:00:00

abstract：:Monensin is a polyether ionophore antibiotic that is widely used in the control of coccidia in animals. Despite its significance in veterinary medicine, little is known about its mode of action and potential mechanisms of resistance in coccidian parasites. Here we show that monensin causes accumulation of the coccidia...

journal_title：Antimicrobial agents and chemotherapy

authors： Lavine MD,Arrizabalaga G

更新日期：2011-02-01 00:00:00

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:Disseminated infections caused by the Mycobacterium avium-M. intracellulare complex (MAC) are the most frequent opportunistic bacterial infections in patients with AIDS. MAC isolates are resistant to many of the standard antituberculous drugs. Failure to obtain significant activities of certain drugs is due to difficu...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT

更新日期：1996-08-01 00:00:00

abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

journal_title：Antimicrobial agents and chemotherapy

authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

更新日期：1999-01-01 00:00:00

abstract：:SCE-129 [3-(4-carbamoyl-1-pyridiniomethyl)-7beta-(d-alpha-sulfophenylacetamido)-ceph-3-em-4-carboxylate monosodium salt], a new semisynthetic cephalosporin, shows potent in vitro antibacterial activities against Pseudomonas aeruginosa and some gram-positive bacteria, whereas it shows lower activity against many gram-n...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuchiya K,Kondo M,Nagatomo H

更新日期：1978-02-01 00:00:00

abstract：:Establishing an effective empirical antifungal therapy requires that national surveillance studies be conducted. Herein, we report the clinical outcome of infections with and the microbiological features of Iranian isolates of Candidaglabrata derived from patients suffering from candidemia. C. glabrata isolates were r...

journal_title：Antimicrobial agents and chemotherapy

authors： Arastehfar A,Daneshnia F,Zomorodian K,Najafzadeh MJ,Khodavaisy S,Zarrinfar H,Hagen F,Zare Shahrabadi Z,Lackner M,Mirhendi H,Salehi M,Roudbary M,Pan W,Kostrzewa M,Boekhout T

更新日期：2019-06-24 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Shaw WR,Uman SJ,Tse FL,Craig WA

更新日期：1975-11-01 00:00:00

abstract：:Wastewater is considered a major source of antibiotic-resistant bacteria released into the environment. Here, we characterized carbapenemase-producing Enterobacteriaceae (CPE) in wastewater by whole-genome analysis. Wastewater samples (n = 40) were collected from municipal wastewater treatment plants and hospital wast...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomi R,Matsuda T,Yamamoto M,Chou PH,Tanaka M,Ichiyama S,Yoneda M,Matsumura Y

更新日期：2018-04-26 00:00:00

abstract：:We analyzed the relationship between rifampin MICs and rpoB mutations of 40 clinical isolates of Mycobacterium tuberculosis. A point mutation in either codon 516, 526, or 531 was found in 13 strains requiring MICs of > or = 64 micrograms/ml, while 21 strains requiring MICs of < or = 1 microgram/ml showed no alteration...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohno H,Koga H,Kohno S,Tashiro T,Hara K

更新日期：1996-04-01 00:00:00

abstract：:We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

更新日期：2007-07-01 00:00:00

abstract：:Staphylococcal biofilms are a major cause of therapeutic failure, especially when caused by multiresistant strains. Oral fusidic acid is currently being redeveloped in the United States for skin, skin structure, and orthopedic infections, in which biofilms play a major role. The aim of this study was to examine the ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Siala W,Rodriguez-Villalobos H,Fernandes P,Tulkens PM,Van Bambeke F

更新日期：2018-06-26 00:00:00

abstract：:The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim YS,Liu Q,Chow LL,Chambers HF,Täuber MG

更新日期：1998-12-01 00:00:00