Antibacterial properties of (2,3)-alpha- and (2,3)-beta-methylene analogs of penicillin G.

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result from increased growth rates at drug-free conditions. We evaluated the differences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jukic E,Blatzer M,Binder U,Mayr L,Lass-Flörl C,Lackner M

更新日期：2017-11-22 00:00:00

abstract：:Many gram-negative bacteria are known to be remarkably resistant to hydrophobic noxious agents by virtue of their outer membranes (OM). We investigated, by using four different assay methods, the ability of sodium hexametaphosphate (HMP) to disrupt this OM barrier. (i) In the growth inhibition assay, HMP was found to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Jaakkola J

更新日期：1989-10-01 00:00:00

abstract：:Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Evron R,Guizie M,Zehavi U,Polacheck I

更新日期：1990-08-01 00:00:00

abstract：:DNA ligases are indispensable enzymes playing a critical role in DNA replication, recombination, and repair in all living organisms. Bacterial NAD+-dependent DNA ligase (LigA) was evaluated for its potential as a broad-spectrum antibacterial target. A novel class of substituted adenosine analogs was discovered by targ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mills SD,Eakin AE,Buurman ET,Newman JV,Gao N,Huynh H,Johnson KD,Lahiri S,Shapiro AB,Walkup GK,Yang W,Stokes SS

更新日期：2011-03-01 00:00:00

abstract：:The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when administered orally every 12 h for 7 days at doses of 100, 200, 300, 400, 600, and 800 mg. Steady-state maximum and minimum...

journal_title：Antimicrobial agents and chemotherapy

authors： Granneman GR,Carpentier P,Morrison PJ,Pernet AG

更新日期：1992-02-01 00:00:00

abstract：:The biliary excretion profile of cefixime was studied in 10 patients provided with T-tube drainage of the common bile duct after cholecystectomy. Following a single 200-mg oral dose, the peak concentration of cefixime in bile reached 56.9 +/- 70 mg/liter, approximately 20 times as high as the peak concentration in ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Westphal JF,Jehl F,Schloegel M,Monteil H,Brogard JM

更新日期：1993-07-01 00:00:00

abstract：:Structure-function relationships in antimicrobial peptides have been extensively investigated in order to obtain improved analogs. Most of these studies have targeted either alpha-helical peptides or beta-sheet peptides with multiple disulfide bridges. Tigerinins are short, nonhelical antimicrobial peptides with a sin...

journal_title：Antimicrobial agents and chemotherapy

authors： Sitaram N,Sai KP,Singh S,Sankaran K,Nagaraj R

更新日期：2002-07-01 00:00:00

abstract：:Polymyxins are increasingly used as a last-resort class of antibiotics against extensively drug-resistant (XDR) Gram-negative bacteria. However, resistance to polymyxins can emerge with monotherapy. As nephrotoxicity is the major dose-limiting factor for polymyxin monotherapy, dose escalation to suppress the emergence...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin YW,Yu HH,Zhao J,Han ML,Zhu Y,Akter J,Wickremasinghe H,Walpola H,Wirth V,Rao GG,Forrest A,Velkov T,Li J

更新日期：2018-05-25 00:00:00

abstract：:The efficacy of a loading dose of 20 mg of chloroquine per kg of body weight per os given at intervals during the first day was evaluated in 27 patients in Madagascar with Plasmodium falciparum malaria. The conventional regimen of 25 mg/kg over 3 days (schedule 1) was thus compared with a regimen of 30 mg/kg over 2 da...

journal_title：Antimicrobial agents and chemotherapy

authors： Pussard E,Lepers JP,Clavier F,Raharimalala L,Le Bras J,Frisk-Holmberg M,Bergqvist Y,Verdier F

更新日期：1991-03-01 00:00:00

abstract：:In order to establish a screening system for xenosiderophores which can be utilized by mycobacteria, we generated a set of mutants of Mycobacterium smegmatis that are blocked in different steps of the well-known iron acquisition system. One mutant with a block in mycobactin biosynthesis was generated from strain mc(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Schumann G,Möllmann U

更新日期：2001-05-01 00:00:00

abstract：:A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously on...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzariol A,Roelofsen E,Koncan R,Voss A,Cornaglia G

更新日期：2007-03-01 00:00:00

abstract：:In this study, our objective was to determine whether a synergistic antimicrobial combination in vitro would be beneficial in the downregulation of pneumococcal virulence genes and whether the associated inflammation of the lung tissue induced by multidrug-resistant Streptococcus pneumoniae infection in vivo needs to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Majhi A,Adhikary R,Bhattacharyya A,Mahanti S,Bishayi B

更新日期：2014-09-01 00:00:00

abstract：:Ribonucleic acid (RNA) synthesis in the sorbitol-dependent, fragile yeast mutant VY1160 (Venkov et al., 1974) is rapidly inhibited by rifampin. The growth of the mutant cells and protein synthesis are more slowly affected by the antibiotic, apparently as secondary phenomena. Lower doses of rifampin (50 to 100 mug/ml) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkov PV,Milchev GI,Hadjiolov AA

更新日期：1975-12-01 00:00:00

abstract：:Ceftibuten (CFB), a new broad-spectrum cephalosporin for oral administration, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens frequently encountered in pediatric patients. Its antimicrobial spectrum and dosage formulation suggest a use for CFB in the treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Kearns GL,Reed MD,Jacobs RF,Ardite M,Yogev RD,Blumer JL

更新日期：1991-10-01 00:00:00

abstract：:Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorable outcomes. The aim of this study was to investigate the pharmacokinetic properties of oseltamivir and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jittamala P,Pukrittayakamee S,Tarning J,Lindegardh N,Hanpithakpong W,Taylor WR,Lawpoolsri S,Charunwattana P,Panapipat S,White NJ,Day NP

更新日期：2014-01-01 00:00:00

abstract：:Nikkomycins are nucleoside-peptide antibiotics produced by Streptomyces species with antifungal activities through the inhibition of chitin synthesis. We investigated the antifungal activities of nikkomycin Z alone and in combination with fluconazole and itraconazole. Checkerboard synergy studies were carried out by a...

journal_title：Antimicrobial agents and chemotherapy

authors： Li RK,Rinaldi MG

更新日期：1999-06-01 00:00:00

abstract：:Four species of members of the family Enterobacteriaceae harboring extended-spectrum beta-lactamase (ESBL) were recovered in a single patient hospitalized in an intensive care unit. Among these isolates, we describe for the first time an ESBL-producing Providencia rettgeri strain. Bacteria from the same species were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchandin H,Carriere C,Sirot D,Pierre HJ,Darbas H

更新日期：1999-08-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Navon-Venezia S,Chmelnitsky I,Schwaber MJ,Carmeli Y

更新日期：2007-08-01 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodero L,Mellado E,Rodriguez AC,Salve A,Guelfand L,Cahn P,Cuenca-Estrella M,Davel G,Rodriguez-Tudela JL

更新日期：2003-11-01 00:00:00

abstract：:To test the hypothesis that establishing gastrointestinal colonization with multiresistant Enterococcus faecium (VRE) C68 results from expansion of the enterococcal population in the upper small bowel, we compared VRE quantities recovered from the proximal, middle, and distal segments of the small bowel from mice trea...

journal_title：Antimicrobial agents and chemotherapy

authors： Lakticová V,Hutton-Thomas R,Meyer M,Gurkan E,Rice LB

更新日期：2006-09-01 00:00:00

abstract：:Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously...

journal_title：Antimicrobial agents and chemotherapy

authors： Joseph P,Abdo MR,Boigegrain RA,Montero JL,Winum JY,Köhler S

更新日期：2007-10-01 00:00:00

abstract：:A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also r...

journal_title：Antimicrobial agents and chemotherapy

authors： McKellar RC,McKenzie CN,Kushner KJ

更新日期：1976-10-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlstrom CA,Ramey AM,Woksepp H,Bonnedahl J

更新日期：2019-07-25 00:00:00

abstract：:There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes in Staphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasive S. aureus (ISA) inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Song KH,Kim M,Kim CJ,Cho JE,Choi YJ,Park JS,Ahn S,Jang HC,Park KH,Jung SI,Yoon N,Kim DM,Hwang JH,Lee CS,Lee JH,Kwak YG,Kim ES,Park SY,Park Y,Lee KS,Lee YS,Kim HB

更新日期：2017-02-23 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00