Biliary excretion of cefixime: assessment in patients provided with T-tube drainage.

abstract：:The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DN...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourel I,Hantz O,Watanabe KA,Jacquet C,Chomel B,Fox JJ,Trepo C

更新日期：1990-03-01 00:00:00

abstract：:The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received two oral doses of 20...

journal_title：Antimicrobial agents and chemotherapy

authors： Espejo E,Andrés M,Garcia MC,Fajardo A,Pérez J,Bella F

更新日期：2018-10-24 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding doma...

journal_title：Antimicrobial agents and chemotherapy

authors： Luo D,Huang L,Gondil VS,Zhou W,Yang W,Jia M,Hu S,He J,Yang H,Wei H

更新日期：2020-11-17 00:00:00

abstract：:The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak MJ,Lerner SA,Levine DP,Albrecht LM,McNeil PL,Thompson GA,Kenny MT,Yuh L

更新日期：1991-04-01 00:00:00

abstract：:In 1891 Guttmann and Ehrlich (P. Guttmann and P. Ehrlich, Berlin Klin. Wochenschr. 28:953-956, 1891) were the first to report the antimalarial properties of a synthetic, rather than a natural, material when they described the clinical cure of two patients after oral administration of a thiazine dye, methylene blue. Si...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Makler MT,Angerhofer CK,Williams JA

更新日期：1995-12-01 00:00:00

abstract：:Replication of measles virus in BSC cells was studied in the presence of enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether), a commonly used volatile anesthetic agent, and its isomer, isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). At clinical concentrations of the anesthetics (up to 4%), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knight PR,Nahrwold ML,Bedows E

更新日期：1981-09-01 00:00:00

abstract：:Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ordonez P,Hamasaki T,Isono Y,Sakakibara N,Ikejiri M,Maruyama T,Baba M

更新日期：2012-05-01 00:00:00

abstract：:Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

更新日期：2014-01-01 00:00:00

abstract：:The direct or indirect interactions that antifungals have with the host immune response may play a significant role in defining their activity in vivo. However, the impact that acquired antifungal resistance has on the immunopharmacologic activity of antifungals is not well described. We assessed the immunopharmacolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Beyda ND,Liao G,Endres BT,Lewis RE,Garey KW

更新日期：2015-09-01 00:00:00

abstract：:Streptococcus pneumoniae is one of the leading pathogens that cause a variety of mucosal and invasive infections. With the increased emergence of multidrug-resistant S. pneumoniae, new antimicrobials with mechanisms of action different from conventional antibiotics are urgently needed. In this study, we identified a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang H,Gong Y,Zhang H,Etobayeva I,Miernikiewicz P,Luo D,Li X,Zhang X,Dąbrowska K,Nelson DC,He J,Wei H

更新日期：2019-03-27 00:00:00

abstract：:Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyadjiev I,Boulamery A,Simon N,Martin C,Bruguerolle B,Leone M

更新日期：2011-07-01 00:00:00

abstract：:Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are copre...

journal_title：Antimicrobial agents and chemotherapy

authors： Desta Z,Soukhova NV,Flockhart DA

更新日期：2001-02-01 00:00:00

abstract：:The accumulation of OPC-17116 by human polymorphonuclear leukocytes was studied by comparison with three other new quinolones, ofloxacin, levofloxacin, and DR-3354. The intracellular/extracellular concentration ratio was the highest for OPC-17116, being 66.2, followed by 9.8 for levofloxacin, 7.6 for ofloxacin, and 5....

journal_title：Antimicrobial agents and chemotherapy

authors： Taira K,Koga H,Kohno S

更新日期：1993-09-01 00:00:00

abstract：:The pore-forming microcin E492 was purified by solid-phase extraction and reversed-phase high-pressure liquid chromatography. Its molecular mass was 7,886 Da. The entire 84-amino-acid sequence was determined. There is no postranslational modification in the secreted microcin, and the sequence has homologies with the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pons AM,Zorn N,Vignon D,Delalande F,Van Dorsselaer A,Cottenceau G

更新日期：2002-01-01 00:00:00

abstract：:Antibiotic penetration to the infection site is critical for obtaining a good clinical outcome in patients with ventilator-associated pneumonia (VAP). Surprisingly few studies have quantified the penetration of β-lactam agents into the lung, as measured by the ratio of area under the concentration-time curve (AUC) in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lodise TP,Sorgel F,Melnick D,Mason B,Kinzig M,Drusano GL

更新日期：2011-04-01 00:00:00

abstract：:Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conf...

journal_title：Antimicrobial agents and chemotherapy

authors： Cagliero C,Mouline C,Cloeckaert A,Payot S

更新日期：2006-11-01 00:00:00

abstract：:This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzitko K,Paneth A,Plech T,Pawełczyk J,Węglińska L,Paneth P

更新日期：2014-12-01 00:00:00

abstract：:It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

更新日期：1999-09-01 00:00:00

abstract：:The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their poten...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes FR,Ferreira WA,Campos MA,Ramos GS,Kato KC,Almeida GG,Corrêa JD Junior,Melo MN,Demicheli C,Frézard F

更新日期：2013-09-01 00:00:00

abstract：:We analyzed the relationship between rifampin MICs and rpoB mutations of 40 clinical isolates of Mycobacterium tuberculosis. A point mutation in either codon 516, 526, or 531 was found in 13 strains requiring MICs of > or = 64 micrograms/ml, while 21 strains requiring MICs of < or = 1 microgram/ml showed no alteration...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohno H,Koga H,Kohno S,Tashiro T,Hara K

更新日期：1996-04-01 00:00:00

abstract：:Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

journal_title：Antimicrobial agents and chemotherapy

authors： Ho II,Chan CY,Cheng AF

更新日期：2000-01-01 00:00:00

abstract：:We describe a primary high-throughput screen that uses the reporter strain Bacillus subtilis BAU-102 to identify antibiotics that induce autolysis. The screen measures autolysis in terms of the incipient release of recombinant Escherichia coli beta-galactosidase (beta-Gal) from the periplasmic space of B. subtilis owi...

journal_title：Antimicrobial agents and chemotherapy

authors： Falk SP,Noah JW,Weisblum B

更新日期：2010-09-01 00:00:00

abstract：:Clindamycin was given intravenously to 15 patients undergoing colorectal surgery in an initial dose of 600 mg, given at induction of anesthesia followed by 6 doses of 600 mg at 8-h intervals. Series of serum samples and fecal specimens were taken for analysis of clindamycin concentrations. Tissue samples from the gut ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kager L,Liljeqvist L,Malmborg AS,Nord CE

更新日期：1981-12-01 00:00:00

abstract：:We report here on a quantitative real-time reverse transcription-PCR (qRT-PCR) assay for assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum. The qRT-PCR assay detects 18S rRNA transcripts from both parasites, that is, the cycle threshold for 18S rRNA from parasites (C(T)([P18S])) and hos...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai X,Woods KM,Upton SJ,Zhu G

更新日期：2005-11-01 00:00:00

abstract：:Antibiotics are generally not effective against organisms in exopolysaccharide biofilms. A simple method of studying the effect of antibiotics on bacteria in established biofilms is reported. Escherichia coli ATCC 25922 cells grown overnight at 37 degrees C on Mueller-Hinton agar were suspended in buffer and dispensed...

journal_title：Antimicrobial agents and chemotherapy

authors： Prosser BL,Taylor D,Dix BA,Cleeland R

更新日期：1987-10-01 00:00:00

abstract：:Plaque formation and dye uptake assays were used to measure the MICs of PD 127,391 and PD 131,628 against Rickettsia species. The MICs of PD 127,391 were 0.25 microgram/ml for Rickettsia rickettsii and 0.125 to 0.25 microgram/ml for Rickettsia conorii. The MICs of PD 131,628 were 0.25 to 0.5 microgram/ml for R. ricket...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabarit-Aldighieri N,Torres H,Raoult D

更新日期：1992-11-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 x 10(-5) M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wanda P,Cupp J,Snipes W,Deith A,Rucinsky T,Polish L,Sands J

更新日期：1976-07-01 00:00:00

abstract：:Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide. Nine single amino acid polymorphisms...

journal_title：Antimicrobial agents and chemotherapy

authors： Compain F,Dorchène D,Arthur M

更新日期：2018-08-27 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a frequent cause of in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bæk KT,Gründling A,Mogensen RG,Thøgersen L,Petersen A,Paulander W,Frees D

更新日期：2014-08-01 00:00:00