Biological activity of staphylococcin 162: bacteriocin from Staphylococcus aureus.

abstract：:Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well understood. We studied an isogenic set of Staphylococcus aureus isolates from the bloodstream of a daptomycin-treated patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones T,Yeaman MR,Sakoulas G,Yang SJ,Proctor RA,Sahl HG,Schrenzel J,Xiong YQ,Bayer AS

更新日期：2008-01-01 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:Macrolide-resistant group A streptococci (MRGAS) have been recovered from many countries worldwide. However, the strain typing information that is available has been insufficient for estimating the total number of macrolide-resistant clones, their geographic distributions, and their evolutionary relationships. In this...

journal_title：Antimicrobial agents and chemotherapy

authors： Robinson DA,Sutcliffe JA,Tewodros W,Manoharan A,Bessen DE

更新日期：2006-09-01 00:00:00

abstract：:We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus...

journal_title：Antimicrobial agents and chemotherapy

authors： Gebremariam T,Alkhazraji S,Baldin C,Kovanda L,Wiederhold NP,Ibrahim AS

更新日期：2017-04-24 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:A membrane fraction from Pseudomonas aeruginosa KM 338 was shown to catalyze in vitro peptidoglycan synthesis from uridine 5'-diphosphate-N-acetylmuramyl-l-alanyl-d- glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine and uridine 5'-diphosphate-N-acetylglucosamine. Synthesized peptidoglycan was partially cross-linked by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H,Ichikawa A,Kotani S

更新日期：1974-12-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Griffith RS,Black HR,Brier GL,Wolny JD

更新日期：1976-11-01 00:00:00

abstract：:Time-kill studies were used to examine the in vitro activities of penicillin G, RP 59500, erythromycin, ciprofloxacin, sparfloxacin, and vancomycin against 10 pneumococci expressing various degrees of susceptibility to penicillin and erythromycin. RP 59500 MICs for all strains were 0.5 to 2.0 micrograms/ml, while eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：1994-09-01 00:00:00

abstract：:Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infections, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk but might increase the risks of renal or liver toxicity or Clostridium diffici...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Huskey RL,Tang L,Inaba H,Gaur AH,Ribeiro R,Rubnitz JE,Wolf J

更新日期：2018-02-23 00:00:00

abstract：:Sixteen weeks of treatment with clarithromycin (CLARI) alone displayed significant bactericidal activity against Mycobacterium avium complex infection in beige mice. Only two combined regimens, CLARI combined with an initial 4 or 8 weeks of amikacin (AMIKA), displayed activity greater than that displayed by CLARI alon...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Ji B,Truffot-Pernot C,Grosset J

更新日期：1995-03-01 00:00:00

abstract：:RBX11160 (OZ277) is a fully synthetic peroxidic antimalarial in clinical development. To study the possible mechanisms of action of RBX11160, we have examined its ability to inhibit PfATP6, a sarcoplasmic reticulum calcium ATPase and proposed target for semisynthetic peroxidic artemisinin derivatives. RBX11160 inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Uhlemann AC,Wittlin S,Matile H,Bustamante LY,Krishna S

更新日期：2007-02-01 00:00:00

abstract：:Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodero L,Mellado E,Rodriguez AC,Salve A,Guelfand L,Cahn P,Cuenca-Estrella M,Davel G,Rodriguez-Tudela JL

更新日期：2003-11-01 00:00:00

abstract：:The efficacy of clarithromycin in a murine model of acute toxoplasmosis was studied. Clarithromycin was administered alone and concurrently with minocycline, and efficacy was assessed by survival rates and sequential determination of parasite burden in blood, brains, and lungs. Limited protection resulted from adminis...

journal_title：Antimicrobial agents and chemotherapy

authors： Derouin F,Caroff B,Chau F,Prokocimer P,Pocidalo JJ

更新日期：1992-12-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00

abstract：:Previous studies showed an increased prevalence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) thumb subdomain polymorphisms Pro272, Arg277, and Thr286 in patients failing therapy with nucleoside analogue combinations. Interestingly, wild-type HIV-1(BH10) RT contains Pro272, Arg277, and Thr2...

journal_title：Antimicrobial agents and chemotherapy

authors： Betancor G,Puertas MC,Nevot M,Garriga C,Martínez MA,Martinez-Picado J,Menéndez-Arias L

更新日期：2010-11-01 00:00:00

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:The in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Hammerschlag MR

更新日期：2003-04-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00

abstract：:In this paper, we present the biochemical and biological evaluation of N-arylmethyl-substituted iminoribitol derivatives as potential chemotherapeutic agents against trypanosomiasis. Previously, a library of 52 compounds was designed and synthesized as potent and selective inhibitors of Trypanosoma vivax inosine-adeno...

journal_title：Antimicrobial agents and chemotherapy

authors： Berg M,Kohl L,Van der Veken P,Joossens J,Al-Salabi MI,Castagna V,Giannese F,Cos P,Versées W,Steyaert J,Grellier P,Haemers A,Degano M,Maes L,de Koning HP,Augustyns K

更新日期：2010-05-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure to metronidazole on the efficacy of a metronidazole-containing eradication regimen. Mice colonized with the metronidazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Jenks PJ,Labigne A,Ferrero RL

更新日期：1999-04-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding doma...

journal_title：Antimicrobial agents and chemotherapy

authors： Luo D,Huang L,Gondil VS,Zhou W,Yang W,Jia M,Hu S,He J,Yang H,Wei H

更新日期：2020-11-17 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:The anti-human immunodeficiency virus type I (anti-HIV-1) effects of gamma-glutamylcysteine ethyl ester (gamma-GCE; TEI-2306) were examined in vitro. In initial studies using a vigorously HIV-1-producing human T-lymphocytic cell line, gamma-GCE displayed a novel biphasic repressive effect on chronic HIV-1 infection th...

journal_title：Antimicrobial agents and chemotherapy

authors： Kubota S,Shetty S,Zhang H,Kitahara S,Pomerantz RJ

更新日期：1998-05-01 00:00:00

abstract：:The in vitro activity of UK31214, a kanamycin B derivative, was studied against 250 recent isolates and compared with other aminoglycosides. Against the Enterobacteriaceae (with the exception of Proteus mirabilis and Providencia stuartii) UK31214 and amikacin had similar degrees of activity (mode minimum inhibitory co...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1980-03-01 00:00:00

abstract：:Macrolide antibiotics like erythromycin can prevent the formation of the 50S ribosomal subunit in growing bacterial cells, in addition to their inhibitory effect on translation. The significance of this novel finding has been further investigated. The 50% inhibitory doses of erythromycin for the inhibition of translat...

journal_title：Antimicrobial agents and chemotherapy

authors： Champney WS,Burdine R

更新日期：1996-05-01 00:00:00

abstract：:Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes ...

journal_title：Antimicrobial agents and chemotherapy

authors： Reno JM,Lee LF,Boezi JA

更新日期：1978-02-01 00:00:00

abstract：:Eighty-nine clinical isolates of Staphylococcus aureus that were resistant to both ciprofloxacin (MIC, greater than or equal to 3.13 micrograms/ml) and methicillin (MIC, greater than or equal to 12.5 micrograms/ml) were divided into two groups with respect to their susceptibilities to AT-4140. Most isolates that were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kojima T,Inoue M,Mitsuhashi S

更新日期：1990-06-01 00:00:00

abstract：:The efficacies of ciprofloxacin and ampicillin against Listeria monocytogenes in an immunosuppressed mouse model of listeriosis were compared. Immunosuppression was achieved by administration of 2.5 mg of hydrocortisone acetate daily. Both ciprofloxacin and ampicillin were effective in reducing the number of viable L....

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Mattie H,Sekh BR,van Strijen E,van Furth R

更新日期：1992-11-01 00:00:00