Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis.

abstract：:We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. Monte Carlo simulations were used to define the permissible HDCI meropenem regimens that could be saf...

journal_title：Antimicrobial agents and chemotherapy

authors： Cojutti P,Sartor A,Righi E,Scarparo C,Bassetti M,Pea F

更新日期：2017-09-22 00:00:00

abstract：:Bradyzoite-to-tachyzoite conversion plays a role in the pathogenesis of recrudescence of ocular toxoplasmosis and disease in immunocompromised persons. The currently available medicines are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. A previous study showed that the histone deacetyla...

journal_title：Antimicrobial agents and chemotherapy

authors： Maubon D,Bougdour A,Wong YS,Brenier-Pinchart MP,Curt A,Hakimi MA,Pelloux H

更新日期：2010-11-01 00:00:00

abstract：:The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA(1) to cfiA(10)) of all ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kato N,Yamazoe K,Han CG,Ohtsubo E

更新日期：2003-03-01 00:00:00

abstract：:Candida parapsilosis has emerged as a common cause of invasive fungal infection, especially in Latin America and in the neonatal setting. C. parapsilosis is part of a closely related group of organisms that includes the species Candida orthopsilosis and Candida metapsilosis. All three species show elevated MICs for th...

journal_title：Antimicrobial agents and chemotherapy

authors： Garcia-Effron G,Katiyar SK,Park S,Edlind TD,Perlin DS

更新日期：2008-07-01 00:00:00

abstract：:In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rhee SY,Liu T,Ravela J,Gonzales MJ,Shafer RW

更新日期：2004-08-01 00:00:00

abstract：:Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD...

journal_title：Antimicrobial agents and chemotherapy

authors： Locher HH,Seiler P,Chen X,Schroeder S,Pfaff P,Enderlin M,Klenk A,Fournier E,Hubschwerlen C,Ritz D,Kelly CP,Keck W

更新日期：2014-01-01 00:00:00

abstract：:Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Wold JS,Turnipseed SA,Broddle WD,Owen NV

更新日期：1977-10-01 00:00:00

abstract：:MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-f...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ

更新日期：1997-08-01 00:00:00

abstract：:We studied the susceptibilities of 77 strains of Neisseria gonorrhoeae to four antibiotics: cefpodoxime, ceftriaxone, penicillin, and tetracycline. All strains were susceptible to ceftriaxone. Cefpodoxime MICs (range, 0.001 to 0.125 micrograms/ml) were parallel to and approximately four times those of ceftriaxone, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Fekete T,Woodwell J,Cundy KR

更新日期：1991-03-01 00:00:00

abstract：:The pharmacokinetics of intravenously administered levofloxacin and ciprofloxacin were studied in intensive care unit patients during continuous venovenous hemofiltration (CVVH; four patients received levofloxacin, and five received ciprofloxacin) or hemodiafiltration (CVVHDF; six patients received levofloxacin, and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to clarify the clarithromycin resistance mechanisms of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae strains. In all clarithromycin-resistant strains, the transcript level of acrB was significantly elevated, and these strains had a frameshift mutation in acrR Introducti...

journal_title：Antimicrobial agents and chemotherapy

authors： Seyama S,Wajima T,Nakaminami H,Noguchi N

更新日期：2016-04-22 00:00:00

abstract：:Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

journal_title：Antimicrobial agents and chemotherapy

authors： Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

更新日期：2016-06-20 00:00:00

abstract：:Helicobacter pylori is a major etiological agent in gastroduodenal disorders. The adhesion of H. pylori to human gastric epithelial cells is the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in the prevention of H. pylori infection. Experiments were performed to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayashi S,Sugiyama T,Amano K,Isogai H,Isogai E,Aihara M,Kikuchi M,Asaka M,Yokota K,Oguma K,Fujii N,Hirai Y

更新日期：1998-08-01 00:00:00

abstract：:The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoeksema M,Brul S,Ter Kuile BH

更新日期：2018-05-25 00:00:00

abstract：:We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics w...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyamoto Y,Takizawa K,Matsushima A,Asai Y,Nakatsuka S

更新日期：1978-03-01 00:00:00

abstract：:In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutio...

journal_title：Antimicrobial agents and chemotherapy

authors： Bougnoux ME,Dannaoui E,Accoceberry I,Angoulvant A,Bailly E,Botterel F,Chevrier S,Chouaki T,Cornet M,Dalle F,Datry A,Dupuis A,Fekkar A,Gangneux JP,Guitard J,Hennequin C,Le Govic Y,Le Pape P,Maubon D,Ranque S,Sautou

更新日期：2016-07-22 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Borowski P,Lang M,Haag A,Schmitz H,Choe J,Chen HM,Hosmane RS

更新日期：2002-05-01 00:00:00

abstract：:The oxazolidinone linezolid represents a new antibacterial class of potential benefit in managing multidrug-resistant gram-positive infections, including those caused by Streptococcus pneumoniae. In a gerbil model of acute otitis media (AOM) induced by either penicillin-resistant S. pneumoniae (PRSP; amoxicillin MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Humphrey WR,Shattuck MH,Zielinski RJ,Kuo MS,Biermacher JJ,Smith DP,Jensen JL,Schaadt RD,Zurenko GE,Richards IM

更新日期：2003-04-01 00:00:00

abstract：:The in vitro activity of trimethoprim plus dapsone against oxacillin-resistant Staphylococcus aureus was comparable to that of trimethoprim plus sulfamethoxazole. Because of its different pharmacologic properties, dapsone may be a useful agent in combination with trimethoprim for the treatment of patients colonized wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lambertus MW,Kwok RY,Mulligan ME

更新日期：1990-07-01 00:00:00

abstract：:This report describes linezolid susceptibility testing results for 6,741 Gram-positive pathogens from 60 U.S. sites collected during 2015 for the LEADER Program. In addition, the report summarizes linezolid in vitro activity, resistance mechanisms, and molecular typing obtained for 2011 to 2015. During 2015, linezolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Mendes RE,Streit JM,Hogan PA,Flamm RK

更新日期：2017-06-27 00:00:00

abstract：:ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae In this study, we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical is...

journal_title：Antimicrobial agents and chemotherapy

authors： Santos-Lopez A,Bernabe-Balas C,Ares-Arroyo M,Ortega-Huedo R,Hoefer A,San Millan A,Gonzalez-Zorn B

更新日期：2017-01-24 00:00:00

abstract：:Serum and milk concentrations of rifamycin SV and rifampin were determined in lactating ewes after a single intravenous injection, and pharmacokinetic parameters were evaluated by the two-compartment open-system model. Rifampin was distributed throughout a greater volume than rifamycin SV and was eliminated more slowl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziv G,Sulman FG

更新日期：1974-02-01 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical A...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1985-07-01 00:00:00

abstract：:The pharmacokinetics of a single 1-g intravenous dose of mezlocillin were examined in six functionally anephric patients undergoing hemodialysis. Hemodialysis clearance calculated by plasma extraction ratios across the dialyzer membrane and by dialysis fluid agree well, averaging 26 and 32 ml/min. Dialyzer extraction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Janicke DM,Mangione A,Schultz RW,Jusko WJ

更新日期：1981-11-01 00:00:00

abstract：:Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro potency, in vitro resistance profile, and activity in combination wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng G,Tian Y,Doehle B,Peng B,Corsa A,Lee YJ,Gong R,Yu M,Han B,Xu S,Dvory-Sobol H,Perron M,Xu Y,Mo H,Pagratis N,Link JO,Delaney W

更新日期：2016-01-11 00:00:00

abstract：:Mecillinam is an amidino penicillinate derivative with a broad spectrum of activity against many gram-negative bacilli. Moreover, marked in vitro synergy against these organisms occurs when mecillinam is combined with other beta-lactam antibiotics. The purpose of this study was to determine the pharmacokinetic disposi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gambertoglio JG,Barriere SL,Lin ET,Conte JE Jr

更新日期：1980-12-01 00:00:00

abstract：:Simocyclinone D8, a coumarin derivative isolated from Streptomyces antibioticus Tü 6040, represents an interesting new antiproliferative agent. It was originally suggested that this drug recognizes the GyrA subunit and interferes with the gyrase catalytic cycle by preventing its binding to DNA. To further characterize...

journal_title：Antimicrobial agents and chemotherapy

authors： Sissi C,Vazquez E,Chemello A,Mitchenall LA,Maxwell A,Palumbo M

更新日期：2010-01-01 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of daptomycin for S. aureus using in vitro methods and the Craig (W. A. Craig, J. Redington, and S. C. Ebert, J. Antimicrob. Chemot...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Kaw P,Liu W,Jumbe N,Miller MH,Drusano GL

更新日期：2001-03-01 00:00:00