Pharmacokinetics of mecillinam in health subjects.

abstract：:Major facilitator superfamily (MFS) efflux pumps have been shown to be important for bacterial cells to cope with biocides such as chlorhexidine (CHX), a widely used molecule in hospital settings. In this work, we evaluated the role of two genes, smvA and smvR, in CHX resistance in Enterobacter cloacae complex (ECC). ...

journal_title：Antimicrobial agents and chemotherapy

authors： Guérin F,Gravey F,Plésiat P,Aubourg M,Beyrouthy R,Bonnet R,Cattoir V,Giard JC

更新日期：2019-12-20 00:00:00

abstract：:Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting the enzymatic activities of CHIKV replication proteins. These pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Das PK,Puusepp L,Varghese FS,Utt A,Ahola T,Kananovich DG,Lopp M,Merits A,Karelson M

更新日期：2016-11-21 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Since beta-lactam antibiotics have concentration-independent killing, bacterial eradication is a function of the time the serum drug concentration remains above the drug's MIC (T > MIC). We compared the serum bactericidal titers (SBTs) of ceftazidime given by continuous infusion (CI) or by intermittent bolus dosing (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicolau DP,Nightingale CH,Banevicius MA,Fu Q,Quintiliani R

更新日期：1996-01-01 00:00:00

abstract：:Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more s...

journal_title：Antimicrobial agents and chemotherapy

authors： Nett JE,Crawford K,Marchillo K,Andes DR

更新日期：2010-08-01 00:00:00

abstract：:Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study. These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Ojo KK,Ulep C,Van Kirk N,Luis H,Bernardo M,Leitao J,Roberts MC

更新日期：2004-09-01 00:00:00

abstract：:The in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Hammerschlag MR

更新日期：2003-04-01 00:00:00

abstract：:Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

journal_title：Antimicrobial agents and chemotherapy

authors： Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

更新日期：2016-03-25 00:00:00

abstract：:Sixty-three consecutive streptococcal blood isolates from neutropenic patients, represented mainly by viridans group streptococci, were evaluated in vitro for antibiotic susceptibility. Of these isolates, 79.3% were highly susceptible to penicillin (MIC, less than or equal to 0.12 microgram/ml). Overall, imipenem was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venditti M,Baiocchi P,Santini C,Brandimarte C,Serra P,Gentile G,Girmenia C,Martino P

更新日期：1989-04-01 00:00:00

abstract：:A total of 100 Streptococcus pneumoniae strains with various penicillin G susceptibilities, isolated in Barcelona, Spain, from different pediatric sources during 1983 and the first 4 months of 1984, were tested for susceptibility to tetracycline, chloramphenicol, erythromycin, clindamycin, vancomycin, and rifampin. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Latorre C,Juncosa T,Sanfeliu I

更新日期：1985-08-01 00:00:00

abstract：:The epidemiology of the two common erythromycin resistance methylase (erm) genes ermA and ermC was analyzed by Southern blotting in 428 erythromycin-resistant Staphylococcus aureus strains isolated from blood between 1959 and 1988 in Denmark. ermA and/or ermC was present in 98% of the erythromycin-resistant strains te...

journal_title：Antimicrobial agents and chemotherapy

authors： Westh H,Hougaard DM,Vuust J,Rosdahl VT

更新日期：1995-02-01 00:00:00

abstract：:Penetration of cefprozil into the middle ear fluid was investigated in patients with chronic otitis media. A total of 89 patients ranging from 7 months to 11 years old participated in the study. The middle ear fluid was removed by ventilation tubes inserted through the tympanic membrane at times ranging from 0.38 to 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Haddad J,Reilly J,Khan WN,Campbell DA,Tsai Y,Barbhaiya RH

更新日期：1994-09-01 00:00:00

abstract：:The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are limited by their cytotoxicity or the lack of RSV B subtype coverage. Here, we characterize a new RSV L inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Tiong-Yip CL,Aschenbrenner L,Johnson KD,McLaughlin RE,Fan J,Challa S,Xiong H,Yu Q

更新日期：2014-07-01 00:00:00

abstract：:The interrelationships between the pharmacokinetics of zidovudine alone and of zidovudine plus clarithromycin were evaluated with 18 volunteers with AIDS who had no infection with Mycobacterium avium complex or clinical evidence of gastroenteritis. Patients received 200 mg of zidovudine orally every 8 h on days 1 to 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Vance E,Watson-Bitar M,Gustavson L,Kazanjian P

更新日期：1995-06-01 00:00:00

abstract：:Hand-foot-and-mouth disease (HFMD), caused by enterovirus, is a threat to public health worldwide. To date, enterovirus 71 (EV71) has been one of the major causative agents of HFMD in the Pacific-Asia region, and outbreaks with EV71 cause millions of infections. However, no drug is currently available for clinical the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang Y,Cao L,Zhai Y,Yin Z,Sun Y,Shang L

更新日期：2017-06-27 00:00:00

abstract：:Lysostaphin is an endopeptidase that kills Staphylococcus aureus, a predominant organism in catheter-related infections. Lysostaphin-coated catheters prevented catheter colonization by several strains of S. aureus, and activity was maintained for at least 4 days. Prophylactic use of lysostaphin in catheters may help p...

journal_title：Antimicrobial agents and chemotherapy

authors： Shah A,Mond J,Walsh S

更新日期：2004-07-01 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Rabbits with nutritionally variant viridans group streptococcal experimental endocarditis were treated three times daily for 3 days with procaine penicillin (1.2 X 10(6) U) alone or together with low-dose streptomycin (2 mg/kg), high-dose streptomycin (8 mg/kg), low-dose gentamicin (0.32 mg/kg), or high-dose gentamici...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry NK,Wilson WR,Roberts RB,Acar JF,Geraci JE

更新日期：1986-09-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryson D,Hettle AG,Boraston AB,Hobbs JK

更新日期：2020-02-21 00:00:00

abstract：:We characterized the stability of a plasmid pCP53-mcr1_3 encoding mcr-1 and mcr-3.19 with and without colistin exposure during cultural passages via S1-pulsed-field gel electrophoresis (PFGE) and nanopore MinION sequencing. Both mcr-1 and mcr-3.19 were missing in certain subclones, mediated by genetic excision (ISApl1...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang P,Bai L,Li Y,Wang Z,Li R

更新日期：2019-08-23 00:00:00

abstract：:The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Bemer P,Juvin ME,Bryskier A,Drugeon H

更新日期：2003-09-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of a clinical isolate of Staphylococcus aureus specifically resistant to oral cephalosporins were compared with those of a susceptible strain. In the resistant strain, PBP3 (75,000 molecular weight) was missing or had substantially (greater than 100-fold) reduced affinity for pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Georgopapadakou NH,Smith SA,Bonner DP

更新日期：1982-07-01 00:00:00

abstract：:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

更新日期：2017-08-24 00:00:00

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00

abstract：:Intragastric inoculation of mice with Klebsiella pneumoniae can cause liver abscesses, necrosis of liver tissues, and bacteremia. A newly isolated phage (φNK5) with lytic activity for K. pneumoniae was used to treat K. pneumoniae infection in an intragastric model. Both intraperitoneal and intragastric administration ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hung CH,Kuo CF,Wang CH,Wu CM,Tsao N

更新日期：2011-04-01 00:00:00

abstract：:A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersinia pestis organisms. Antibiotics were administered by intraperitoneal...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne WR,Welkos SL,Pitt ML,Davis KJ,Brueckner RP,Ezzell JW,Nelson GO,Vaccaro JR,Battersby LC,Friedlander AM

更新日期：1998-03-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shalit I,Barnea A,Shahar A

更新日期：1989-05-01 00:00:00