Serum bactericidal activity of ceftazidime: continuous infusion versus intermittent injections.

abstract：:SCCmec is a mobile genetic element that carries the gene (mecA) mediating methicillin resistance in staphylococci. For Staphylococcus aureus, four SCCmec types have been described, one (type IV) of which has been associated with newly identified community-acquired methicillin-resistant S. aureus. However, the distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wisplinghoff H,Rosato AE,Enright MC,Noto M,Craig W,Archer GL

更新日期：2003-11-01 00:00:00

abstract：:As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent inhibition of ergoste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanden Bossche H,Marichal P,Le Jeune L,Coene MC,Gorrens J,Cools W

更新日期：1993-10-01 00:00:00

abstract：:A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An exce...

journal_title：Antimicrobial agents and chemotherapy

authors： Lichtenwalner DM,Suh B,Lorber B,Sugar AM

更新日期：1979-08-01 00:00:00

abstract：:A major clinical challenge for treating infectious diseases is the duration of antimicrobial therapy required to eradicate the pathogen. We hypothesized that modulation of the bacterial replication rate in the context of an antimicrobial exposure is coupled with the rate and extent of bactericidal effects. Herein we d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambrose PG,VanScoy B,Conde H,McCauley J,Rubino CM,Bhavnani SM

更新日期：2016-12-27 00:00:00

abstract：:Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

journal_title：Antimicrobial agents and chemotherapy

authors： Azimi PH,Dunphy MG

更新日期：1989-09-01 00:00:00

abstract：:Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S,Bowlin TL

更新日期：2011-01-01 00:00:00

abstract：:Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have precluded direct pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

更新日期：2004-04-01 00:00:00

abstract：:This study summarizes the linezolid susceptibility testing results for 7,429 Gram-positive pathogens from 60 U.S. sites collected during the 2012 sampling year for the LEADER Program. Linezolid showed potent activity when tested against 2,980 Staphylococcus aureus isolates, inhibiting all but 3 at ≤2 μg/ml. Similarly,...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendes RE,Flamm RK,Hogan PA,Ross JE,Jones RN

更新日期：2014-01-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:Zika virus (ZIKV), a flavivirus transmitted by mosquitoes, was an almost neglected pathogen until its introduction in the Americas in 2015 and its subsequent explosive spread throughout the continent, where it has infected millions of people. The virus has caused social and sanitary alarm, mainly due to its associatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Saiz JC,Martín-Acebes MA

更新日期：2017-05-24 00:00:00

abstract：:This study compared nine susceptibility testing methods and 12 endpoints for anidulafungin, caspofungin, and micafungin with the same collection of blinded FKS hot spot mutant (n = 29) and wild-type isolates (n = 94). The susceptibility tests included EUCAST Edef 7.1, agar dilution, Etest, and disk diffusion with RPMI...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Garcia-Effron G,Lass-Flörl C,Lopez AG,Rodriguez-Tudela JL,Cuenca-Estrella M,Perlin DS

更新日期：2010-01-01 00:00:00

abstract：:Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ordonez P,Hamasaki T,Isono Y,Sakakibara N,Ikejiri M,Maruyama T,Baba M

更新日期：2012-05-01 00:00:00

abstract：:As a consequence of blood-borne bacterial sepsis, endotoxin or lipopolysaccharide (LPS) from the cell walls of gram-negative bacteria can trigger an acute inflammatory response, leading to a series of pathological events and often resulting in death. To block this inflammatory response to endotoxin, a novel lipid A an...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi S,Kawata T,Kimura A,Miyamoto K,Katayama K,Yamatsu I,Rossignol DP,Christ WJ,Kishi Y

更新日期：1998-11-01 00:00:00

abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

更新日期：2020-01-27 00:00:00

abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

journal_title：Antimicrobial agents and chemotherapy

authors： Teuber M,Bader J

更新日期：1976-01-01 00:00:00

abstract：:MICs of 25 Abiotrophia defectiva and 109 Granulicatella adiacens isolates were determined by broth microdilution. Using CLSI breakpoints, the susceptibilities of A. defectiva and G. adiacens isolates were, respectively, 24% and 34% to penicillin, 92% and 22% to ceftriaxone, 48% and 3% to cefepime, 72% and 87% to merop...

journal_title：Antimicrobial agents and chemotherapy

authors： Mushtaq A,Greenwood-Quaintance KE,Cole NC,Kohner PC,Ihde SM,Strand GJ,Harper LW,Virk A,Patel R

更新日期：2016-07-22 00:00:00

abstract：:The effects on Staphylococcus aureus viability and beta-lactamase activity of concentrations that simulated those in human serum after a combined dose of 875 mg of amoxicillin and 125 mg of clavulanic acid were studied in an in vitro pharmacodynamic model. Six hours of preexposure to concentrations of the amoxicillin-...

journal_title：Antimicrobial agents and chemotherapy

authors： Aguilar L,Martín M,Balcabao IP,Gómez-Lus ML,Dal-Ré R,Prieto J

更新日期：1997-06-01 00:00:00

abstract：:A reverse-phase high-pressure liquid chromatography method for the quantitation of sulbactam in plasma, urine, and tissue is described. The assay used the formation of an imidazole derivative followed by extraction with acetonitrile and dichloromethane and used UV absorbance for detection. The mobile phase consisted o...

journal_title：Antimicrobial agents and chemotherapy

authors： Bawdon RE,Madsen PO

更新日期：1986-08-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis (HVH) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. Treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(I:C)] significantly increased the mean survival time and markedly altered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-06-01 00:00:00

abstract：:Eight healthy male volunteers received 1 g of either ceftazidime or cefamandole as an intravenous infection. Serial blood samples were taken over the next 8 h. Urine samples were collected over 24 h. Levels of these antibiotics were measured in the fluid of blisters resulting from application of cantharides. The conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Armstrong GC,Wise R,Brown RM,Hancox J

更新日期：1981-09-01 00:00:00

abstract：:PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae IK,Jang SJ,Kim J,Jeong SH,Cho B,Lee K

更新日期：2011-03-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:We report a microanalytical high-performance liquid chromatography method for quantitation of cefpirome (HR 810) from serum. The drug was extracted from 0.05 ml of serum with 0.2 ml of isopropanol containing beta-hydroxypropyltheophylline, the internal standard. Separations were performed on a C18 column at ambient te...

journal_title：Antimicrobial agents and chemotherapy

authors： Turley CP,Kearns GL,Jacobs RF

更新日期：1988-10-01 00:00:00

abstract：:The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

journal_title：Antimicrobial agents and chemotherapy

authors： Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-07-01 00:00:00

abstract：:The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies carried out using ...

journal_title：Antimicrobial agents and chemotherapy

authors： VanScoy BD,Trang M,McCauley J,Conde H,Bhavnani SM,Friedrich LV,Alexander DC,Ambrose PG

更新日期：2016-06-20 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:Use of combinations of antimicrobials that together achieve synergistic activities against targeted microorganisms is one potential strategy for overcoming bacterial resistance. As the incidence of infections caused by multidrug-resistant staphylococci and enterococci increases, the importance of devising additional s...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Cha R,Rybak MJ

更新日期：2002-08-01 00:00:00

abstract：:Clostridium difficile is the most frequently identified enteric pathogen in patients with nosocomially acquired, antibiotic-associated diarrhea. The drugs most commonly used to treat diseases associated with C. difficile are metronidazole and vancomycin. Most clinical laboratories assume that all C. difficile isolates...

journal_title：Antimicrobial agents and chemotherapy

authors： Peláez T,Alcalá L,Alonso R,Rodríguez-Créixems M,García-Lechuz JM,Bouza E

更新日期：2002-06-01 00:00:00

abstract：:Monensin is a polyether ionophore antibiotic that is widely used in the control of coccidia in animals. Despite its significance in veterinary medicine, little is known about its mode of action and potential mechanisms of resistance in coccidian parasites. Here we show that monensin causes accumulation of the coccidia...

journal_title：Antimicrobial agents and chemotherapy

authors： Lavine MD,Arrizabalaga G

更新日期：2011-02-01 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00