Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum β-lactamase.

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange experiments to genera...

journal_title：Antimicrobial agents and chemotherapy

authors： Plinke C,Walter K,Aly S,Ehlers S,Niemann S

更新日期：2011-06-01 00:00:00

abstract：:Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Adjei GO,Kristensen K,Goka BQ,Hoegberg LC,Alifrangis M,Rodrigues OP,Kurtzhals JA

更新日期：2008-12-01 00:00:00

abstract：:The role of mutations in the genes for GyrA and ParC in quinolone resistance in Mycoplasma hominis was studied. Selection with sparfloxacin gave mutations at GyrA83 (Ser-->Leu; Escherichia coli numbering) or GyrA87 (Glu-->Lys), and mutants had increased levels of resistance to sparfloxacin (8- to 16-fold) but not to o...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Young PA,Cartwright FD,Sjöström KE,Huang WM

更新日期：1999-10-01 00:00:00

abstract：:More than 10(6) compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL4-3 in MT-2 and PM1 cells, with 50% effective concentrations of 1.3 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blair WS,Cao J,Jackson L,Jimenez J,Peng Q,Wu H,Isaacson J,Butler SL,Chu A,Graham J,Malfait AM,Tortorella M,Patick AK

更新日期：2007-10-01 00:00:00

abstract：:Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wingard JR,Bender WJ,Saral R,Burns WH

更新日期：1981-08-01 00:00:00

abstract：:Therapeutic options for severe infections caused by strains of oxacillin-resistant Staphylococcus aureus (ORSA) and coagulase-negative staphylococci (ORSE) are very limited. With the increasing resistance of such strains to aminoglycosides, rifampin, and currently available quinolone agents, as well as the recent docu...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Li C,Ing M

更新日期：1998-07-01 00:00:00

abstract：:The class 1 integron In28, found in the multidrug resistance transposon Tn1403, was found to be located in the res site of the backbone transposon and is flanked by a 5-bp direct duplication, indicating that it reached this position by transposition. In28 has a backbone structure related to that of In4, but has lost i...

journal_title：Antimicrobial agents and chemotherapy

authors： Partridge SR,Recchia GD,Stokes HW,Hall RM

更新日期：2001-11-01 00:00:00

abstract：:One hundred clinical isolates of methicillin-resistant (Metr) Staphylococcus aureus from five different geographical origins were tested for their susceptibility to 12 non-beta-lactam antibiotics by the broth microdilution technique recommended by the National Committee for Clinical Laboratory Standards. Coumermycin a...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Janney A,Sanders CV

更新日期：1985-11-01 00:00:00

abstract：:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

更新日期：2018-06-26 00:00:00

abstract：:Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately posttherapy, pretreatment signs and symptoms resolved among 91% of the 33 evaluable patients. At 6 months, all 28 of the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Dattwyler RJ,Grunwaldt E,Luft BJ

更新日期：1996-02-01 00:00:00

abstract：:When strains harboring R factor and showing ampicillin (APC) resistance were inoculated on plates containing various concentrations of APC, mutants carrying various levels of APC resistance occurred at high frequencies. Increases in the level of APC resistance were due to a quantitative increase in the formation of pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Odakura Y,Tanaka T,Hashimoto H,Mitsuhashi S

更新日期：1973-03-01 00:00:00

abstract：:The kinetics of the lethal action of metronidazole and the formation of acetamide have been studied in a strain of Bacteroides fragilis which is relatively resistant to metronidazole. As with a susceptible strain of B. fragilis, the data are consistent with a model in which a labile intermediate in metronidazole metab...

journal_title：Antimicrobial agents and chemotherapy

authors： McLafferty MA,Koch RL,Goldman P

更新日期：1982-01-01 00:00:00

abstract：:Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus disease. We therefore...

journal_title：Antimicrobial agents and chemotherapy

authors： Mellors JW,Bazmi HZ,Schinazi RF,Roy BM,Hsiou Y,Arnold E,Weir J,Mayers DL

更新日期：1995-05-01 00:00:00

abstract：:LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett, S. M. Galloway, S....

journal_title：Antimicrobial agents and chemotherapy

authors： Mdluli KE,Witte PR,Kline T,Barb AW,Erwin AL,Mansfield BE,McClerren AL,Pirrung MC,Tumey LN,Warrener P,Raetz CR,Stover CK

更新日期：2006-06-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:In 1989 and 1990, a large number of ampicillin-resistant strains of Enterococcus faecium were isolated from infected patients treated at intensive care units in Berlin, Germany. Twenty-five clinical isolates, including five different biotypes as classified by acid production from various sugars and a wide range of sus...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare I,Rodloff AC,Wagner J,Witte W,Hakenbeck R

更新日期：1992-04-01 00:00:00

abstract：:An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respect...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto T,Nagata M,Ishimine N,Kawasaki K,Yamauchi K,Hidaka E,Kasuga E,Horiuchi K,Oana K,Kawakami Y,Honda T

更新日期：2012-01-01 00:00:00

abstract：:Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Borowski P,Lang M,Haag A,Schmitz H,Choe J,Chen HM,Hosmane RS

更新日期：2002-05-01 00:00:00

abstract：:BMS-207147, Sch 56592, and voriconazole are three new investigational triazoles with broad-spectrum antifungal activity. The in vitro activities of these three agents were compared with those of itraconazole and fluconazole against 1,300 bloodstream isolates of Candida species obtained from over 50 different medical c...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Messer SA,Hollis RJ,Jones RN,Doern GV,Brandt ME,Hajjeh RA

更新日期：1998-12-01 00:00:00

abstract：:By means of a stepwise selection procedure, mutants capable of growing in the presence of relatively high multiplicities of a bacteriocin from Streptococcus mutans GS-5 were obtained from a sensitivie strain of Streptococcus pyogenes. Mutacin-neutralizing activity of cell extracts containing receptor protein was exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Franker CK

更新日期：1980-02-01 00:00:00

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of minimum inhibitory concentrations (MIC) based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Vijay S,Nhung HN,Bao NLH,Thu DDA,Trieu LPT,Phu NH,Thwaites GE,Javid B,Thuong NTT

更新日期：2020-11-30 00:00:00

abstract：:In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins L,Franzblau SG

更新日期：1997-05-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a neutropenic murine lung in...

journal_title：Antimicrobial agents and chemotherapy

authors： Crandon JL,Kuti JL,Nicolau DP

更新日期：2010-12-01 00:00:00

abstract：:A mutant (TX5127) of Enterococcus faecalis OG1RF was generated by disruption mutagenesis of a previously described autolysin gene. TX5127 formed longer chains (2 to 10 cells per chain) than wild-type OG1RF (mainly single cells) during growth in broth even though it had a growth rate similar to that of the parental str...

journal_title：Antimicrobial agents and chemotherapy

authors： Qin X,Singh KV,Xu Y,Weinstock GM,Murray BE

更新日期：1998-11-01 00:00:00