In vitro assessment of the effect of clavulanic acid at concentrations achieved in human serum on the bactericidal activity of amoxicillin at physiological concentrations against Staphylococcus aureus: implications for dosage regimens.

abstract：:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandelbrot L,Duro D,Belissa E,Peytavin G

更新日期：2014-09-01 00:00:00

abstract：:PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae IK,Jang SJ,Kim J,Jeong SH,Cho B,Lee K

更新日期：2011-03-01 00:00:00

abstract：:3-Decynoyl-N-acetylcystamine is known to inhibit the in vitro growth of Escherichia coli but not of yeasts or mammalian cells. Neither the free acid nor the 2 positional isomer is active (L. R. Kass, J. Biol. Chem. 243:3223-3228, 1968). Other studies have shown that 2-hexadecynoic acid is fungitoxic whereas most of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Konthikamee W,Gilbertson JR,Langkamp H,Gershon H

更新日期：1982-11-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblas...

journal_title：Antimicrobial agents and chemotherapy

authors： Broeckel R,Sarkar S,May NA,Totonchy J,Kreklywich CN,Smith P,Graves L,DeFilippis VR,Heise MT,Morrison TE,Moorman N,Streblow DN

更新日期：2019-03-27 00:00:00

abstract：:GS-9148 is an investigational phosphonate nucleotide analogue inhibitor of reverse transcriptase (RT) (NtRTI) of human immunodeficiency virus type 1 (HIV-1). This compound is an adenosine derivative with a 2',3'-dihydrofuran ring structure that contains a 2'-fluoro group. The resistance profile of GS-9148 is unique in...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarth BJ,White KL,Chen JM,Lansdon EB,Swaminathan S,Miller MD,Götte M

更新日期：2011-06-01 00:00:00

abstract：:The pharmacokinetics of gentamicin in 34 febrile neutropenic patients (40 courses) were compared with those in 40 nonneutropenic patients receiving the drug. No pharmacokinetic differences were seen in half-life, volume of distribution (liter per kilogram; total and ideal body weight), or clearance (milliliter per min...

journal_title：Antimicrobial agents and chemotherapy

authors： Bianco TM,Dwyer PN,Bertino JS Jr

更新日期：1989-11-01 00:00:00

abstract：:The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rossignol T,Kelly B,Dobson C,d'Enfert C

更新日期：2011-10-01 00:00:00

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nair S,Desai S,Poonacha N,Vipra A,Sharma U

更新日期：2016-11-21 00:00:00

abstract：:There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest...

journal_title：Antimicrobial agents and chemotherapy

authors： Abe F,Ueyama J,Kawasumi N,Nadai M,Hayashi T,Kato M,Ohnishi M,Saito H,Takeyama N,Hasegawa T

更新日期：2008-09-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:Morbidity and mortality resulting from influenza-like disease are a threat, especially for older adults. To improve case management, next-generation broad-spectrum antiviral therapeutics that are efficacious against major drivers of influenza-like disease, including influenza viruses and respiratory syncytial virus (R...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon JJ,Toots M,Lee S,Lee ME,Ludeke B,Luczo JM,Ganti K,Cox RM,Sticher ZM,Edpuganti V,Mitchell DG,Lockwood MA,Kolykhalov AA,Greninger AL,Moore ML,Painter GR,Lowen AC,Tompkins SM,Fearns R,Natchus MG,Plemper RK

更新日期：2018-07-27 00:00:00

abstract：:The objectives of this study were to (i) construct a population pharmacokinetic (PK) model able to describe vancomycin (VAN) concentrations in serum in pediatric patients, (ii) determine VAN PK parameters in this population, and (iii) validate the predictive ability of this model in a naive pediatric population. Data ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamarre P,Lebel D,Ducharme MP

更新日期：2000-02-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:During HIV-1 reverse transcription, there are increasing opportunities for nucleos(t)ide (NRTI) or nonnucleoside (NNRTI) reverse transcriptase (RT) inhibitors to stop elongation of the nascent viral DNA (vDNA). In addition, RT inhibitors appear to influence the kinetics of vDNA synthesis differently. While cell-free k...

journal_title：Antimicrobial agents and chemotherapy

authors： Abram ME,Tsiang M,White KL,Callebaut C,Miller MD

更新日期：2015-02-01 00:00:00

abstract：:In addition to cholesterol-lowering capabilities, statins possess anti-inflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized pati...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey AR,Timbrook TT,Noh E,Sakoulas G,Opal SM,Nizet V,LaPlante KL

更新日期：2017-02-23 00:00:00

abstract：:Various steroids were tested for their effects upon gonococcal O2 consumption and glucose catabolism. The ability to inhibit gonococcal O2 uptake appeared to be related to the molecular configuration of the steroid. The presence of lipophilic groups enhanced inhibition, whereas the addition of hydrophilic groups marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Lysko PG,Morse SA

更新日期：1980-08-01 00:00:00

abstract：:Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Cosgrove S,Harris A,Eliopoulos GM,Carmeli Y

更新日期：2001-09-01 00:00:00

abstract：:Vancomycin is a renally excreted drug, and its body clearance correlates with creatinine clearance. However, the renal function estimation equation that best predicts vancomycin clearance has not been established yet. The objective of this study was to compare the abilities of different renal function estimation equat...

journal_title：Antimicrobial agents and chemotherapy

authors： Glatard A,Bourguignon L,Jelliffe RW,Maire P,Neely MN,Goutelle S

更新日期：2015-01-01 00:00:00

abstract：:We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n=250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobsson S,Golparian D,Alm RA,Huband M,Mueller J,Jensen JS,Ohnishi M,Unemo M

更新日期：2014-09-01 00:00:00

abstract：:We found that cells of Vibrio parahaemolyticus possess an energy-dependent efflux system for norfloxacin. We cloned a gene for a putative norfloxacin efflux protein from the chromosomal DNA of V. parahaemolyticus by using an Escherichia coli mutant lacking the major multidrug efflux system AcrAB as the host and sequen...

journal_title：Antimicrobial agents and chemotherapy

authors： Morita Y,Kodama K,Shiota S,Mine T,Kataoka A,Mizushima T,Tsuchiya T

更新日期：1998-07-01 00:00:00

abstract：:Seven bla(IMP-1)-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86, carrying the same cassette array [bla(IMP1), aac(6')-31, and aadA1], which was plasmid located in five of the isolates. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendes RE,Castanheira M,Toleman MA,Sader HS,Jones RN,Walsh TR

更新日期：2007-07-01 00:00:00

abstract：:Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for the treatment of and prophylaxis against influenza. In this paper, the new potent NA inhibitor R-125489 is reported for the first time. R-125489 inhibited the NA activities of various type A and B influen...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita M,Tomozawa T,Kakuta M,Tokumitsu A,Nasu H,Kubo S

更新日期：2009-01-01 00:00:00

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00

abstract：:Recalcitrant dermatophytoses are on the rise in India. High MICs of terbinafine (TRB) and squalene epoxidase (SQLE) gene mutations conferring resistance in Trichophyton spp. have been recently documented. However, studies correlating laboratory data with clinical response to TRB in tinea corporis/cruris are lacking. F...

journal_title：Antimicrobial agents and chemotherapy

authors： Khurana A,Masih A,Chowdhary A,Sardana K,Borker S,Gupta A,Gautam RK,Sharma PK,Jain D

更新日期：2018-11-26 00:00:00

abstract：:An in situ method for sensitive detection of differences in the action of chlorhexidine against subpopulations of cells in Candida albicans biofilms is described. Detection relies on monitoring the kinetics of propidium iodide (PI) penetration into the cytoplasm of individual cells during dosing with chlorhexidine. Ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Suci PA,Tyler BJ

更新日期：2002-11-01 00:00:00

abstract：:Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 μg/ml but not among isolates with MICs of ≤ 0.032 μg/ml. Experimental infection of cipr...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong E,Thulin Hedberg S,Abad R,Fazio C,Enríquez R,Deghmane AE,Jolley KA,Stefanelli P,Unemo M,Vazquez JA,Veyrier FJ,Taha MK

更新日期：2013-04-01 00:00:00