NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli.

abstract：:Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

更新日期：2019-02-26 00:00:00

abstract：:The small-colony-variant (SCV) phenotype of Staphylococcus aureus has been associated with difficult-to-treat infections, reduced antimicrobial susceptibility, and intracellular persistence. This study represents a detailed intra- and extracellular investigation of a clinical wild-type (WT) S. aureus strain and its co...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandberg A,Lemaire S,Van Bambeke F,Tulkens PM,Hughes D,von Eiff C,Frimodt-Møller N

更新日期：2011-04-01 00:00:00

abstract：:Escherichia coli bearing a cryptic tetracycline resistance determinant from Bacteroides fragilis expressed low-level constitutive resistance to tetracycline under aerobic, but not anaerobic, growth conditions and accumulated less tetracycline aerobically than did isogenic susceptible cells. This decreased uptake was e...

journal_title：Antimicrobial agents and chemotherapy

authors： Park BH,Hendricks M,Malamy MH,Tally FP,Levy SB

更新日期：1987-11-01 00:00:00

abstract：:In 2002, the first two clinical isolates of vancomycin-resistant Staphylococcus aureus (VRSA) containing vanA were recovered in Michigan and Pennsylvania. Tn1546, a mobile genetic element that encodes high-level vancomycin resistance in enterococci, was present in both isolates. With PCR and DNA sequence analysis, we ...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark NC,Weigel LM,Patel JB,Tenover FC

更新日期：2005-01-01 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:Carbapenemase-producing Enterobacteriaceae isolates (n = 110) from health care centers in central Indiana (from 2010 to 2013) were tested for susceptibility to combinations of avibactam (4 μg/ml) with ceftazidime, ceftaroline, or aztreonam. MIC50/MIC90 values were 1/2 μg/ml (ceftazidime-avibactam), 0.5/2 μg/ml (ceftar...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Kashikar A,Brown CA,Denys G,Bush K

更新日期：2017-07-25 00:00:00

abstract：:Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozano S,Gamallo P,González-Cortés C,Presa Matilla JL,Fairhurst RM,Herreros E,Amaratunga C,Rodrigues J

更新日期：2018-11-26 00:00:00

abstract：:MurG and MraY, essential enzymes involved in the synthesis of bacterial peptidoglycan, are difficult to assay because the substrates are lipidic and hard to prepare in large quantities. Based on the use of Escherichia coli membranes lacking PBP1b, we report a high-throughput method to measure the activity of MurG and,...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravishankar S,Kumar VP,Chandrakala B,Jha RK,Solapure SM,de Sousa SM

更新日期：2005-04-01 00:00:00

abstract：:Bacterial resistance studies using in vitro dynamic models are highly dependent on the starting inoculum that might or might not contain spontaneously resistant mutants (RMs). To delineate concentration-resistance relationships with linezolid-exposed Staphylococcus aureus, a mixed inoculum containing both susceptible ...

journal_title：Antimicrobial agents and chemotherapy

authors： Firsov AA,Golikova MV,Strukova EN,Portnoy YA,Romanov AV,Edelstein MV,Zinner SH

更新日期：2015-02-01 00:00:00

abstract：:The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman D,Bryskier A,Lowther J,Appelbaum PC

更新日期：2006-11-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:A novel trait for transferable resistance to high concentrations of trimethoprim was found to dominate among enterobacteria collected from different parts of Sri Lanka. Drug resistance was a result of the production of dihydrofolate reductase with a decreased sensitivity to antifolates. By characterization of the part...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundström L,Vinayagamoorthy T,Sköld O

更新日期：1987-01-01 00:00:00

abstract：:Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory co...

journal_title：Antimicrobial agents and chemotherapy

authors： Andersen NM,Poehlsgaard J,Warrass R,Douthwaite S

更新日期：2012-11-01 00:00:00

abstract：:The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. carinii pneumonitis in 90% or more of rats, while all untreated control a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Gray VL,Gutteridge WE,Latter VS,Pudney M

更新日期：1990-02-01 00:00:00

abstract：:Since currently available therapies against HIV/AIDS still show important drawbacks, the development of novel anti-HIV treatments is a key issue. We recently characterized methylated oligoribonucleotides (mONs) that extensively inhibit HIV-1 replication in primary T cells at nanomolar concentrations. The mONs were sho...

journal_title：Antimicrobial agents and chemotherapy

authors： Avilov SV,Boudier C,Gottikh M,Darlix JL,Mély Y

更新日期：2012-02-01 00:00:00

abstract：:Bloodstream infection (BSI) due to multidrug-resistant Klebsiella is associated with high rates of morbidity and mortality. The aim of this study was to identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Anderson DJ,Engemann JJ,Harrell LJ,Carmeli Y,Reller LB,Kaye KS

更新日期：2006-05-01 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. In this study, we combined evolutionary sequence analyses, computational structural modeling, and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity difference...

journal_title：Antimicrobial agents and chemotherapy

authors： Dey D,Kavanaugh LG,Conn GL

更新日期：2020-07-22 00:00:00

abstract：:Titanium (Ti) is a promising candidate biomaterial for an artificial corneal skirt. Antimicrobial peptide (AMP) immobilization may improve the bactericidal effect of the Ti substrate. In this study, we tested the bactericidal efficacy of a functionalized Ti surface in a rabbit keratitis model. A corneal stromal pocket...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan XW,Goh TW,Saraswathi P,Nyein CL,Setiawan M,Riau A,Lakshminarayanan R,Liu S,Tan D,Beuerman RW,Mehta JS

更新日期：2014-09-01 00:00:00

abstract：:BILN 2061 is a novel, specific hepatitis C virus (HCV) NS3 serine protease inhibitor discovered by Boehringer Ingelheim that has shown potent activity against HCV replicons in tissue culture and is currently under clinical investigation for the treatment of HCV infection. The poor fidelity of the HCV RNA-dependent RNA...

journal_title：Antimicrobial agents and chemotherapy

authors： Lu L,Pilot-Matias TJ,Stewart KD,Randolph JT,Pithawalla R,He W,Huang PP,Klein LL,Mo H,Molla A

更新日期：2004-06-01 00:00:00

abstract：:Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be ...

journal_title：Antimicrobial agents and chemotherapy

authors： Davidson MG,Lappin MR,Rottman JR,Tompkins MB,English RV,Bruce AT,Jayawickrama J

更新日期：1996-06-01 00:00:00

abstract：:Recent pharmacokinetic studies that included children found that serum drug levels were low compared to those of adults for whom the same dosages were used. This study aimed to characterize the pharmacokinetics of pyrazinamide and ethambutol in Malawian children and to examine the impact of age, nutritional status, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Graham SM,Bell DJ,Nyirongo S,Hartkoorn R,Ward SA,Molyneux EM

更新日期：2006-02-01 00:00:00

abstract：:The activities of teicoplanin and vancomycin against 362 coagulase-negative staphylococci were determined by an agar dilution method. At the 4- and 32-micrograms/ml breakpoint levels of the National Committee for Clinical Laboratory Standards, 23.2% of the strains were intermediate and 1.7% were resistant to teicoplan...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein FW,Coutrot A,Sieffer A,Acar JF

更新日期：1990-05-01 00:00:00

abstract：:A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 50% inhibitory conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Severin A,Chopra R,Krishnamurthy G,Singh G,Hu W,Keeney D,Svenson K,Petersen PJ,Labthavikul P,Shlaes DM,Rasmussen BA,Failli AA,Shumsky JS,Kutterer KM,Gilbert A,Mansour TS

更新日期：2006-02-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against Staphylococcus aureus, including methicillin-resistant strains, and Streptococcus pneumoniae an...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanabe A,Tokue Y,Takahashi H,Kikuchi T,Kobayashi T,Gomi K,Fujimura S,Nukiwa T

更新日期：1999-07-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:Resistance to ceftazidime, detected in isolates of Escherichia coli 5518 and Enterobacter gergoviae 3773 from our hospital, was transferred, together with resistance to aminoglycosides, trimethoprim, sulfonamide, and other beta-lactam antibiotics, by conjugation to E. coli JP559. Both E. coli transconjugants were resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng Y,Chen M

更新日期：1994-12-01 00:00:00

abstract：:Escherichia coli K-12 cells grown in 1 to 5 mM sodium salicylate (SAL) or acetylsalicylate show increased phenotypic resistance to various antibiotics (J. L. Rosner, Proc. Natl. Acad. Sci. USA 82:8771-8774, 1985), including cephalosporins (this study). To determine whether these effects are caused by a decreased uptak...

journal_title：Antimicrobial agents and chemotherapy

authors： Foulds J,Murray DM,Chai T,Rosner JL

更新日期：1989-04-01 00:00:00