Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro.

abstract：:Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical A...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1985-07-01 00:00:00

abstract：:Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFA-resistant mutant (HSV-PFA(r)) and the PAA-resistant mutant (HSV-PAA(r)) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Oberg B

更新日期：1979-06-01 00:00:00

abstract：:The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically...

journal_title：Antimicrobial agents and chemotherapy

authors： Cid D,Piriz S,Ruiz-Santa-Quiteria JA,Valle J,Garcia S,Vadillo S,de la Fuente R

更新日期：1994-10-01 00:00:00

abstract：:Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA mutations (A90V, A90V-S...

journal_title：Antimicrobial agents and chemotherapy

authors： Giannoni F,Iona E,Sementilli F,Brunori L,Pardini M,Migliori GB,Orefici G,Fattorini L

更新日期：2005-07-01 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:Aspergillus fumigatus infections are associated with high mortality rates and high treatment costs. Limited available antifungals and increasing antifungal resistance highlight an urgent need for new antifungals. Thioredoxin reductase (TrxR) is essential for maintaining redox homeostasis and presents as a promising ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marshall AC,Kidd SE,Lamont-Friedrich SJ,Arentz G,Hoffmann P,Coad BR,Bruning JB

更新日期：2019-02-26 00:00:00

abstract：:Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang GW,Brunel JM,Bolla JM,Van Bambeke F

更新日期：2020-12-14 00:00:00

abstract：:We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

更新日期：2017-04-24 00:00:00

abstract：:The role of extracellular DNA in the maintenance of biofilms formed by gram-positive and gram-negative bacteria was studied. This study evaluated all the bacterial strains that were tested for the presence of extracellular DNA with an average size of 30 kb in the matrix. Our results indicate changes in community bioma...

journal_title：Antimicrobial agents and chemotherapy

authors： Tetz GV,Artemenko NK,Tetz VV

更新日期：2009-03-01 00:00:00

abstract：:A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153-165, 1996). In parallel...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RG,Rosowsky A

更新日期：2001-12-01 00:00:00

abstract：:Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with t...

journal_title：Antimicrobial agents and chemotherapy

authors： Markantonis SL,Markou N,Fousteri M,Sakellaridis N,Karatzas S,Alamanos I,Dimopoulou E,Baltopoulos G

更新日期：2009-11-01 00:00:00

abstract：:We studied the susceptibilities of 77 strains of Neisseria gonorrhoeae to four antibiotics: cefpodoxime, ceftriaxone, penicillin, and tetracycline. All strains were susceptible to ceftriaxone. Cefpodoxime MICs (range, 0.001 to 0.125 micrograms/ml) were parallel to and approximately four times those of ceftriaxone, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Fekete T,Woodwell J,Cundy KR

更新日期：1991-03-01 00:00:00

abstract：:The available treatments for leishmaniasis are less than optimal due to inadequate efficacy, toxic side effects, and the emergence of resistant strains, clearly endorsing the urgent need for discovery and development of novel drug candidates. Ideally, these should act via an alternative mechanism of action to avoid cr...

journal_title：Antimicrobial agents and chemotherapy

authors： Sebastián-Pérez V,Hendrickx S,Munday JC,Kalejaiye T,Martínez A,Campillo NE,de Koning H,Caljon G,Maes L,Gil C

更新日期：2018-09-24 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium rel...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen WC,Chou DL,Feingold DS

更新日期：1978-06-01 00:00:00

abstract：:Ceftizoxime, a new cephalosporin, was active against Pseudomonas cepacia, Flavobacterium meningosepticum, Alcaligenes faecalis, and Acinetobacter calcoaceticus and was more potent against Pseudomonas aeruginosa and Pseudomonas putida than was carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yabuuchi E,Ito T,Tanimura E,Yamamoto N,Ohyama A

更新日期：1981-07-01 00:00:00

abstract：:Two antilipidemic compounds, clofibrate and procetofene, inhibited the replication of herpes simplex virus type 1 (HSV-1) in African green monkey kidney cells. Clofibrate, at a concentration of 400 mumol/liter caused a 63% reduction (P < 0.001) in HSV-1 yield and at 100 mumol/liter caused a 62% reduction (P < 0.001) i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehl JK,Witiak DT,Hamparian VV,Hughes JH

更新日期：1980-08-01 00:00:00

abstract：:Polymyxin B nonapeptide, derived by cleavage of the fatty acyl diaminobutyric acid from polymyxin B, is considerably less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. The peptide rendered all 53 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ofek I,Cohen S,Rahmani R,Kabha K,Tamarkin D,Herzig Y,Rubinstein E

更新日期：1994-02-01 00:00:00

abstract：:Human cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sá NP,Lima CM,Lino CI,Barbeira PJS,Baltazar LM,Santos DA,Oliveira RB,Mylonakis E,Fuchs BB,Johann S

更新日期：2017-07-25 00:00:00

abstract：:Five R plasmids transferred from Asian strains of Vibrio cholerae all proved to be members of compatibility group C. A non-self-transmissible plasmid, stable in V. cholerae, was mobilized for transfer to Escherichia coli K-12 and found to be unstably inherited in that host. Plasmids of group C and P transferred to a w...

journal_title：Antimicrobial agents and chemotherapy

authors： Hedges RW,Vialard JL,Pearson NJ,O'Grady F

更新日期：1977-04-01 00:00:00

abstract：:A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greates...

journal_title：Antimicrobial agents and chemotherapy

authors： de la Maza L,Ruoff KL,Ferraro MJ

更新日期：1989-08-01 00:00:00

abstract：:We have evaluated the susceptibility of the murine gamma herpesvirus 68 (MHV-68) to a variety of antiviral agents. The acyclic nucleoside phosphonate analogs cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine], (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA), and adefovir [9-(2-phosphonylmethox...

journal_title：Antimicrobial agents and chemotherapy

authors： Neyts J,De Clercq E

更新日期：1998-01-01 00:00:00

abstract：:Time-kill studies examined the activities of telithromycin (HMR 3647), erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, pristinamycin, amoxicillin-clavulanate, and metronidazole against 11 gram-positive and gram-negative anaerobic bacteria. Time-kill studies were carried out with the addition ...

journal_title：Antimicrobial agents and chemotherapy

authors： Credito KL,Ednie LM,Jacobs MR,Appelbaum PC

更新日期：1999-08-01 00:00:00

abstract：:We report here on a quantitative real-time reverse transcription-PCR (qRT-PCR) assay for assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum. The qRT-PCR assay detects 18S rRNA transcripts from both parasites, that is, the cycle threshold for 18S rRNA from parasites (C(T)([P18S])) and hos...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai X,Woods KM,Upton SJ,Zhu G

更新日期：2005-11-01 00:00:00

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:A rapid microbiological assay for chlorhydroxyquinoline is described. It is a turbidimetric procedure that uses Streptococcus faecalis as the test organism. Results are available within 5 h. Data are presented to show the advantages of using a cryogenically stored inoculum over an inoculum prepared on a daily basis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cosgrove RF

更新日期：1977-05-01 00:00:00

abstract：:Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used intravenous antibiotic for the empirical treatment of infection in intensive care patients, including burn patients. The purpose of this study was to develop a population pharmacokinetic (PK) model for piperacillin in burn patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeon S,Han S,Lee J,Hong T,Paek J,Woo H,Yim DS

更新日期：2014-07-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a frequent cause of in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bæk KT,Gründling A,Mogensen RG,Thøgersen L,Petersen A,Paulander W,Frees D

更新日期：2014-08-01 00:00:00

abstract：:During a 4-month period in late 1988, we isolated ceftazidime-resistant strains of Klebsiella pneumoniae and other members of the family Enterobacteriaceae from 29 patients at a chronic-care facility in Massachusetts. Ceftazidime resistance resulted from two distinct extended-spectrum beta-lactamases of the TEM type w...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Willey SH,Papanicolaou GA,Medeiros AA,Eliopoulos GM,Moellering RC Jr,Jacoby GA

更新日期：1990-11-01 00:00:00

abstract：:The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Paphitou NI,Ostrosky-Zeichner L,Paetznick VL,Rodriguez JR,Chen E,Rex JH

更新日期：2002-04-01 00:00:00