Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs.

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nie B,Long T,Ao H,Zhou J,Tang T,Yue B

更新日期：2016-12-27 00:00:00

abstract：:A47934, a peptide antibiotic produced by Streptomyces toyocaensis, belongs to the glycopeptide class of compounds which includes ristocetin and vancomycin. Incorporation studies with radioisotope-labeled substrates indicated that tyrosine, p-hydroxyphenylglycine, p-hydroxyphenylglyoxylate, acetate, and sulfate were ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Zmijewski MJ Jr,Briggs B,Logan R,Boeck LD

更新日期：1987-10-01 00:00:00

abstract：:Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and i...

journal_title：Antimicrobial agents and chemotherapy

authors： Stürmer M,Stephan C,Gute P,Knecht G,Bickel M,Brodt HR,Doerr HW,Gürtler L,Lecocq P,van Houtte M

更新日期：2011-11-01 00:00:00

abstract：:Sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. They have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. This new family of compounds has also shown in vivo activity against murine Can...

journal_title：Antimicrobial agents and chemotherapy

authors： Aviles P,Pateman A,San Roman R,Guillén MJ,Gómez De Las Heras F,Gargallo-Viola D

更新日期：2001-10-01 00:00:00

abstract：:Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SC...

journal_title：Antimicrobial agents and chemotherapy

authors： Espedido BA,Steen JA,Barbagiannakos T,Mercer J,Paterson DL,Grimmond SM,Cooper MA,Gosbell IB,van Hal SJ,Jensen SO

更新日期：2012-06-01 00:00:00

abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

journal_title：Antimicrobial agents and chemotherapy

authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

更新日期：2017-10-24 00:00:00

abstract：:CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase, was derived by mutagenesis. The hydrolytic efficiency of CMY-30 against expanded-spectrum cephalosporins was higher than that of CMY-2 due to increased k(cat) values. Findings indicate a role of the Omega loop residue 211 in determining the substrate specificities ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kotsakis SD,Papagiannitsis CC,Tzelepi E,Tzouvelekis LS,Miriagou V

更新日期：2009-08-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00

abstract：:Continued research toward the development of new antifungals that act via inhibition of glycosylphosphatidylinositol (GPI) biosynthesis led to the design of E1210. In this study, we assessed the selectivity of the inhibitory activity of E1210 against Candida albicans GWT1 (Orf19.6884) protein, Aspergillus fumigatus GW...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanabe NA,Miyazaki M,Horii T,Sagane K,Tsukahara K,Hata K

更新日期：2012-02-01 00:00:00

abstract：:Phosphonoformate (PF) at a concentration of 5 to 10 mug/ml inhibited the growth of type 1 strains of herpes simplex virus (HSV) in tissue culture, whereas 20 to 30 mug/ml was required for inhibition of type 2 strains and about 50 mug/ml was required for murine cytomegalovirus. In mice inoculated intraperitoneally or i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Glasgow LA,Overall JC Jr,Reno JM,Boezi JA

更新日期：1978-12-01 00:00:00

abstract：:The class C beta-lactamase of Citrobacter freundii GN346 is a typical cephalosporinase comprising 361 amino acids, and substitution of the glutamic acid at position 219 in the enzyme by lysine was previously shown to broaden its substrate spectrum to oxyimino beta-lactams (K. Tsukamoto, R. Ohno, and T. Sawai, J. Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

更新日期：1994-06-01 00:00:00

abstract：:Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupont M,James CE,Chevalier J,Pagès JM

更新日期：2007-09-01 00:00:00

abstract：:Three structural analogs of 5-ethyl-1-benzyloxymethyl-6-(phenylthio)uracil (E-BPU) inhibited human immunodeficiency virus type 1 (HIV-1) replication without cytotoxicity in vitro and were more potent than azidothymidine and were as potent as E-BPU. The target of these compounds is HIV-1 reverse transcriptase. Reverse ...

journal_title：Antimicrobial agents and chemotherapy

authors： Piras G,Dutschman GE,Im GJ,Pan BC,Chu SH,Cheng YC

更新日期：1995-02-01 00:00:00

abstract：:The relationship between the structures of quinolones and their anti-Mycobacterium avium activities has been previously derived by using the Multiple Computer-Automated Structure Evaluation program. A number of substructural constraints required to overcome the resistance of most of the strains have been identified. N...

journal_title：Antimicrobial agents and chemotherapy

authors： Klopman G,Li JY,Wang S,Pearson AJ,Chang K,Jacobs MR,Bajaksouzian S,Ellner JJ

更新日期：1994-08-01 00:00:00

abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

更新日期：2020-01-27 00:00:00

abstract：:The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grewal J,Manavathu EK,Taylor DE

更新日期：1993-12-01 00:00:00

abstract：:Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Benbrook DM,Miller RV

更新日期：1986-01-01 00:00:00

abstract：:Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft DS

更新日期：1997-03-01 00:00:00

abstract：:There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

journal_title：Antimicrobial agents and chemotherapy

authors： Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

更新日期：2020-09-21 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time cur...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Andes DR

更新日期：2019-10-22 00:00:00

abstract：:An international interlaboratory quality control program for measurement of antiretroviral drugs was initiated. The first round was confined to protease inhibitors and showed large variability in the performance of participating laboratories. The results demonstrate the need for and utility of an ongoing quality contr...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarnoutse RE,Verweij-van Wissen CP,van Ewijk-Beneken Kolmer EW,Wuis EW,Koopmans PP,Hekster YA,Burger DM

更新日期：2002-03-01 00:00:00

abstract：:Twelve straight-chain esters, C(5) to C(14), C(16), and C(18), of p-hydroxybenzoic acid were prepared, and their melting points, solubilities in water at 25 degrees C, infrared spectra, dissociation constants (pK(a)), and activities against Clostridium botulinum were determined. These studies also included four commer...

journal_title：Antimicrobial agents and chemotherapy

authors： Dymicky M,Huhtanen CN

更新日期：1979-06-01 00:00:00

abstract：:The resistance-nodulation-division (RND)-type efflux pump is one of the causes of the multidrug resistance of Stenotrophomonas maltophilia. The roles of the RND-type efflux pump in physiological functions and virulence, in addition to antibiotic extrusion, have attracted much attention. In this study, the contribution...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin YT,Huang YW,Chen SJ,Chang CW,Yang TC

更新日期：2015-07-01 00:00:00

abstract：:The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis. In vitro studies were performed with MRC5 fibroblast tissue cultures, with quantification of Toxoplasma growth by an enzyme-linked immunosor...

journal_title：Antimicrobial agents and chemotherapy

authors： Romand S,Pudney M,Derouin F

更新日期：1993-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal model of HCV gene expres...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang H,Hanecak R,Brown-Driver V,Azad R,Conklin B,Fox MC,Anderson KP

更新日期：1999-02-01 00:00:00

abstract：:Klebsiella pneumoniae causes common and severe hospital- and community-acquired infections with a high incidence of multidrug resistance. The emergence and spread of beta-lactamase-producing K. pneumoniae strains highlight the need to develop new therapeutic strategies. In this study, we developed antisense peptide nu...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurupati P,Tan KS,Kumarasinghe G,Poh CL

更新日期：2007-03-01 00:00:00

abstract：:Two of the most common causes of inflammatory enteritis are Campylobacter fetus subsp. jejuni and Shigella species. No single antimicrobial agent is recommended for treatment of both diseases. Erythromycin is used to treat C. fetus subsp. jejuni infections but has not been studied in shigellosis. For this reason, we d...

journal_title：Antimicrobial agents and chemotherapy

authors： Greenberg RN,Pearson RD,Innes DJ,Sauer KT,Halterman LD,Guerrant RL

更新日期：1982-02-01 00:00:00