Inhibition of gene expression and growth by antisense peptide nucleic acids in a multiresistant beta-lactamase-producing Klebsiella pneumoniae strain.

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. The overall rate of beta-lactamase production was 95.3%. When the National...

journal_title：Antimicrobial agents and chemotherapy

authors： Doern GV,Brueggemann AB,Pierce G,Hogan T,Holley HP Jr,Rauch A

更新日期：1996-12-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:S. aureus combats cell wall antibiotic stress by altered gene expression mediated by various environmental signal sensors. In this study, we examined the transcriptional regulation of trfA, a gene related to mecA of Bacillus subtilis encoding an adaptor protein implicated in multiple roles, notably, proteolysis and ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Jousselin A,Kelley WL,Barras C,Lew DP,Renzoni A

更新日期：2013-07-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin great...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Fuchs PC,Sommers HM,Gavan TL,Barry AL,Gerlach EH

更新日期：1980-04-01 00:00:00

abstract：:The in vitro activities of extracts of Nigerian chewing sticks against Bacteroides gingivalis and B. melaninogenicus are presented. The greatest inhibitory action was produced by Serindeia werneckei, whereas Fagara zanthoxyloides produced no appreciable inhibitory effect. A generally good correlation was found between...

journal_title：Antimicrobial agents and chemotherapy

authors： Rotimi VO,Laughon BE,Bartlett JG,Mosadomi HA

更新日期：1988-04-01 00:00:00

abstract：:Racial differences in antiretroviral treatment responses remain incompletely explained and may be a consequence of differential pharmacokinetics (PK) associated with race. Raltegravir, an inhibitor of HIV-1 integrase, is commonly used in the treatment of HIV-infected patients, many of whom are African-American. Howeve...

journal_title：Antimicrobial agents and chemotherapy

authors： Wohl DA,Dumond JB,Blevins S,Pittard D,Ragan D,Wang R,Massengale K,Walsh K,Floris-Moore M,Eron JJ Jr,Richardson A,Hudgens MG,Kashuba AD

更新日期：2013-02-01 00:00:00

abstract：:Resistance to rifampin in Mycobacterium tuberculosis results from mutations in the gene coding for the beta subunit of RNA polymerase (rpoB). At least 95% of rifampin-resistant isolates have mutations in rpoB, and the mutations are clustered in a small region. About 40 distinct point mutations and in-frame insertions ...

journal_title：Antimicrobial agents and chemotherapy

authors： Morlock GP,Plikaytis BB,Crawford JT

更新日期：2000-12-01 00:00:00

abstract：:Staphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hertlein T,Sturm V,Lorenz U,Sumathy K,Jakob P,Ohlsen K

更新日期：2014-01-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:The antifungal pentapeptide auristatin PHE was recently shown to interfere with microtubule dynamics and nuclear and cellular division in the opportunistic pathogen Cryptococcus neoformans. To gain a broader understanding of the cellular response of C. neoformans to auristatin PHE, mRNA differential display (DD) and r...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Berens ME,Hoelzinger DB,Pettit GR,Winkelmann G,Pettit RK

更新日期：2004-02-01 00:00:00

abstract：:We report the ultrastructural alterations induced during the proliferative stages of Trypanosoma (Schizotrypanum) cruzi, the causative agent of Chagas' disease, by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, which had previously been shown to be potent growth inhibitors whose effects are pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazardi K,Urbina JA,de Souza W

更新日期：1990-11-01 00:00:00

abstract：:Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with N. gonorrhoeae are...

journal_title：Antimicrobial agents and chemotherapy

authors： Dukers-Muijrers NH,van Liere GA,Wolffs PF,Den Heijer C,Werner MI,Hoebe CJ

更新日期：2015-01-01 00:00:00

abstract：:The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grewal J,Manavathu EK,Taylor DE

更新日期：1993-12-01 00:00:00

abstract：:Penetration of cefprozil into the middle ear fluid was investigated in patients with chronic otitis media. A total of 89 patients ranging from 7 months to 11 years old participated in the study. The middle ear fluid was removed by ventilation tubes inserted through the tympanic membrane at times ranging from 0.38 to 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Haddad J,Reilly J,Khan WN,Campbell DA,Tsai Y,Barbhaiya RH

更新日期：1994-09-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:T-8581 is a new water-soluble triazole antifungal agent. The geometric mean IC80s (GM-IC80S; where the IC80 is the lowest drug concentration which reduced the optical density at 630 nm by 80% compared with the optical density at 630 nm of the drug-free control) for Candida albicans were as follows: T-8581, 0.218 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Shimizu K,Araki H,Fujimaki K,Nishida N,Hori R,Annen N,Yamamoto S,Hayakawa H,Imaizumi H,Watanbe Y,Narita H

更新日期：1997-01-01 00:00:00

abstract：:Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： He R,Yang Y,Wu Y,Zhong LL,Yang Y,Chen G,Qin M,Liang X,Ahmed MAEE,Lin M,Yan B,Xia Y,Dai M,Chen H,Tian GB

更新日期：2021-01-20 00:00:00

abstract：:Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show here that the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Arita-Morioka K,Yamanaka K,Mizunoe Y,Ogura T,Sugimoto S

更新日期：2015-01-01 00:00:00

abstract：:Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by se...

journal_title：Antimicrobial agents and chemotherapy

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2009-12-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:The 47-kbp plasmid pGFT1 from Salmonella enterica subsp. enterica serovar Dublin mediated tetracycline resistance via a tet(A) gene located on an integrated copy of a Tn1721-analogous transposon. The integration site of the transposon was located within the reading frame of a fip gene. Plasmid pGFT1 was shown to be co...

journal_title：Antimicrobial agents and chemotherapy

authors： Frech G,Schwarz S

更新日期：1998-05-01 00:00:00

abstract：:There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a range of medically significant pathogens. Previous work using Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Djoko KY,Goytia MM,Donnelly PS,Schembri MA,Shafer WM,McEwan AG

更新日期：2015-10-01 00:00:00

abstract：:Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalosporinase from Enter...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Freudenberger JS,Sykes RB

更新日期：1982-09-01 00:00:00

abstract：:Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma G,Khan SI,Jacob MR,Tekwani BL,Li Z,Pasco DS,Walker LA,Khan IA

更新日期：2004-11-01 00:00:00

abstract：:Bloodstream infection (BSI) due to multidrug-resistant Klebsiella is associated with high rates of morbidity and mortality. The aim of this study was to identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Anderson DJ,Engemann JJ,Harrell LJ,Carmeli Y,Reller LB,Kaye KS

更新日期：2006-05-01 00:00:00

abstract：:Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy volunteers, using biomarkers for safety and efficacy. Subjects were ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallis RS,Jakubiec W,Kumar V,Bedarida G,Silvia A,Paige D,Zhu T,Mitton-Fry M,Ladutko L,Campbell S,Miller PF

更新日期：2011-02-01 00:00:00

abstract：:To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in comparison w...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams GC,Liu A,Knipp G,Sinko PJ

更新日期：2002-11-01 00:00:00