Inducible resistance of fish bacterial pathogens to the antimicrobial peptide cecropin B.

abstract：:Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiskirchen DE,Nordmann P,Crandon JL,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:Community-onset (CO) candidemia, defined as a positive blood culture taken at or within 2 days of hospital admission, represents a distinct clinical entity associated with substantial morbidity and mortality. Reference MIC results from the SENTRY Antimicrobial Surveillance Program (2008-2009) were analyzed to compare ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Moet GJ,Messer SA,Jones RN,Castanheira M

更新日期：2011-02-01 00:00:00

abstract：:Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC D...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdugo D,Fallows D,Ahuja S,Schluger N,Kreiswirth B,Mathema B

更新日期：2015-10-01 00:00:00

abstract：:Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and c...

journal_title：Antimicrobial agents and chemotherapy

authors： Tabary X,Moreau N,Dureuil C,Le Goffic F

更新日期：1987-12-01 00:00:00

abstract：:The in vitro activity of cefazolin was assessed by continuous turbidimetric monitoring of cultures of gram-negative bacilli and the results were compared with those previously obtained with other beta-lactam agents using the same strains and methods. Cefazolin was found to induce rapid lysis of ampicillin-susceptible ...

journal_title：Antimicrobial agents and chemotherapy

authors： Greenwood D,Chan-Teoh CH,O'Grady F

更新日期：1975-02-01 00:00:00

abstract：:The binding of the outer membrane-disorganizing peptide polymyxin B nonapeptide (PMBN) to gram-negative bacteria was studied by using tritium-labeled PMBN. Smooth Salmonella typhimurium had a binding capacity of ca. 6 nmol of PMBN per mg (dry weight) of bacteria, which corresponds to ca. 1 X 10(6) to 2 X 10(6) molecul...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Viljanen P

更新日期：1985-04-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:β-Lactam resistance levels vary among methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, mediated by chromosomal mutations and exogenous resistance gene mecA However, MRSA resistance mechanisms are incompletely understood. A P440L mutation in the RNA polymerase β' subunit (RpoC) in slow-vancomycin-i...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Yamamoto N,Hishinuma T,Hiramatsu K

更新日期：2019-01-29 00:00:00

abstract：:The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and beta-lactams, respectively (P < 0.01 for macrolides versus beta-lactams). We conclude ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Kofteridis DP,Manios A,Pediaditis J,Tselentis Y

更新日期：2001-12-01 00:00:00

abstract：:A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic...

journal_title：Antimicrobial agents and chemotherapy

authors： Gerard M,Meunier F,Dor P,Andry G,Chantrain G,Van der Auwera P,Daneau D,Klastersky J

更新日期：1988-10-01 00:00:00

abstract：:In published studies, cohorts of patients with bacteremia due to vancomycin-resistant Enterococcus (VRE) have predominantly been infected with Enterococcus faecium. Little is known about the epidemiology and outcomes associated with bacteremia due to VR Enterococcus faecalis. A retrospective study of isolates obtained...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa K,Marchaim D,Martin ET,Tiwari N,Yousuf A,Sunkara B,Pulluru H,Kotra H,Hasan A,Bheemreddy S,Sheth P,Lee DW,Kamatam S,Bathina P,Nanjireddy P,Chalana IK,Patel S,Kumar S,Vahia A,Ku K,Yee V,Swan J,Pogue JM

更新日期：2012-05-01 00:00:00

abstract：:Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Hallett P,Maxwell A

更新日期：1991-02-01 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131) is a pandemic clonal lineage that is responsible for the global increase in fluoroquinolone resistance and extended-spectrum-β-lactamase (ESBL) producers. The members of ST131 clade C, especially subclades C2 and C1-M27, are associated with ESBLs. We developed a multiplex con...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura Y,Pitout JDD,Peirano G,DeVinney R,Noguchi T,Yamamoto M,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2017-07-25 00:00:00

abstract：:We describe a rapid, precise, and simple procedure for the quantitation of azlocillin in serum and in aqueous solutions by high-pressure, reverse-phase liquid chromatography. This method uses a single precipitation step, detection by dual-wavelength monitoring (220 and 254 nm), and quantitation by comparison with an i...

journal_title：Antimicrobial agents and chemotherapy

authors： Weber A,Opheim KE,Wong K,Smith AL

更新日期：1983-11-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of res...

journal_title：Antimicrobial agents and chemotherapy

authors： Hetherington SV,Watson AS,Patrick CC

更新日期：1995-09-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:Antibiotic penetration to the infection site is critical for obtaining a good clinical outcome in patients with ventilator-associated pneumonia (VAP). Surprisingly few studies have quantified the penetration of β-lactam agents into the lung, as measured by the ratio of area under the concentration-time curve (AUC) in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lodise TP,Sorgel F,Melnick D,Mason B,Kinzig M,Drusano GL

更新日期：2011-04-01 00:00:00

abstract：:Despite dose-limiting nephrotoxicity concerns, polymyxin B has resurged as the treatment of last resort for multidrug-resistant Gram-negative bacterial infections. However, the pharmacokinetic, pharmacodynamic, and nephrotoxic properties of polymyxin B still are not thoroughly understood. The objective of this study w...

journal_title：Antimicrobial agents and chemotherapy

authors： Manchandani P,Zhou J,Ledesma KR,Truong LD,Chow DS,Eriksen JL,Tam VH

更新日期：2015-12-07 00:00:00

abstract：:Oral doses of norfloxacin (80 mg/kg of body weight per day) and ciprofloxacin (25 and 80 mg/kg/day) and intramuscular doses of teicoplanin (5 mg/kg/day), all administered once a day for 10 days, were evaluated as a means of preventing encrusted cystitis caused by Corynebacterium group D2. Zinc disks dipped into a 24-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Soriano F,Rodriguez-Tudela JL,Castilla C,Avilés P

更新日期：1991-12-01 00:00:00

abstract：:The susceptibility of 12 strains of Mobiluncus curtisii and 10 strains of M. mulieris to 23 antimicrobial agents and 15 other compounds was determined. All strains were susceptible to chloramphenicol, clindamycin, rifampin, tobramycin, vancomycin, virginiamycin, and all beta-lactam antibiotics tested, including imipen...

journal_title：Antimicrobial agents and chemotherapy

authors： Spiegel CA

更新日期：1987-02-01 00:00:00

abstract：:We developed a multiplex PCR assay capable of identifying two capsular polysaccharide synthesis sequence types (sequence type 258 [ST258] cps-1 and cps-2) in epidemic Klebsiella pneumoniae ST258 strains. The assay performed with excellent sensitivity (100%) and specificity (100%) for identifying cps types in 60 ST258 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen L,Chavda KD,Findlay J,Peirano G,Hopkins K,Pitout JD,Bonomo RA,Woodford N,DeLeo FR,Kreiswirth BN

更新日期：2014-07-01 00:00:00

abstract：:The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than a...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott NW,Harwood CR

更新日期：1981-04-01 00:00:00

abstract：:P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nair S,Desai S,Poonacha N,Vipra A,Sharma U

更新日期：2016-11-21 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing numbers of immune suppression techniques to treat other medical conditions and transplantation. Despite these advances, morbidity and mortality rates remain unacceptably high. One strategy used to optimize outcomes is antifungal pharma...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Marchillo K,Vanhecker J,Andes DR

更新日期：2013-12-01 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:A novel stilbene glycoside [piceid-(1-->6)-beta-d-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean surv...

journal_title：Antimicrobial agents and chemotherapy

authors： Park WH,Lee SJ,Moon HI

更新日期：2008-09-01 00:00:00

abstract：:In the eubacterial cell, the peptidoglycan is perpetually hydrolyzed throughout the cell cycle by different enzymes such as lytic transglycosylases, endopeptidases, and amidases. In Escherichia coli, four N-acetylmuramoyl-l-alanine amidases, AmiA, -B, -C, and -D, are present in the periplasm. AmiA, -B, and -C are solu...

journal_title：Antimicrobial agents and chemotherapy

authors： Pennartz A,Généreux C,Parquet C,Mengin-Lecreulx D,Joris B

更新日期：2009-07-01 00:00:00

abstract：:We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-09-01 00:00:00