High-pressure liquid chromatographic quantitation of azlocillin.

abstract：:Parasitic diseases are of enormous public health significance in developing countries-a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one ...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey CR,Steverding D,Swenerton RK,Kelly B,Walshe D,Debnath A,Zhou YM,Doyle PS,Fafarman AT,Zorn JA,Land KM,Beauchene J,Schreiber K,Moll H,Ponte-Sucre A,Schirmeister T,Saravanamuthu A,Fairlamb AH,Cohen FE,McKerrow

更新日期：2007-06-01 00:00:00

abstract：:Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy. In spite of its therapeutic value, CFZ therapy is accompanied by the formation of drug biocrystals that accumulate within resident tissue macrophages, without obvious toxicological manifestations. Theref...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon GS,Keswani RK,Sud S,Rzeczycki PM,Murashov MD,Koehn TA,Standiford TJ,Stringer KA,Rosania GR

更新日期：2016-05-23 00:00:00

abstract：:The pharmacokinetics of meropenem and its ring-opened metabolite (ICI 213,689) were investigated with eight young (20- to 34-year-old) and eight elderly (67- to 80-year-old) healthy male volunteers given single 30-min intravenous infusions of 500 mg of meropenem. All subjects had normal age-correlated glomerular funct...

journal_title：Antimicrobial agents and chemotherapy

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1992-07-01 00:00:00

abstract：:The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile...

journal_title：Antimicrobial agents and chemotherapy

authors： Seiler P,Enderlin-Paput M,Pfaff P,Weiss M,Ritz D,Clozel M,Locher HH

更新日期：2015-10-26 00:00:00

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen with increasing prevalence, which is able to cause infections in immunocompromised patients or in those with a previous pathology. The treatment of the infections caused by this bacterium is often complicated due to the several intrinsic antibiotic resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco P,Corona F,Sánchez MB,Martínez JL

更新日期：2017-04-24 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The effect of incubation with interferon prior to the stimulation of interferon production (priming) and of sequential treatment with cycloheximide and actinomycin D (superinduction) on the interferon yield from polyinosinic-polycytidylic acid (poly I.poly C)-induced diploid human foreskin cell cultures (FS-3 strain) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Havell EA,Vilcek J

更新日期：1972-12-01 00:00:00

abstract：:The inactivation of virus-contaminated nonporous inanimate surfaces was investigated using adenovirus type 8, a common cause of epidemic keratoconjunctivitis. A 10-microl inoculum of adenovirus was placed onto each stainless steel disk (1-cm diameter), and the inoculum was allowed to air dry for 40 min. Twenty-one dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Rutala WA,Peacock JE,Gergen MF,Sobsey MD,Weber DJ

更新日期：2006-04-01 00:00:00

abstract：:The biliary excretion of moxalactam was studied in 11 postsurgery patients who had indwelling T-tubes inserted in their common bile ducts. Peak levels of moxalactam in the bile reached mean levels of 33.7 +/- 11.1 and 173.7 +/- 67.0 micrograms/ml 2 h after intravenous administration of a single 500- or 2,000-mg dose, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez OV,Levi JU,Livingstone A,Malinin TI,Zeppa R,Hutson D,Einhorn N

更新日期：1981-08-01 00:00:00

abstract：:The Cpx stress response is widespread among Enterobacteriaceae We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA....

journal_title：Antimicrobial agents and chemotherapy

authors： Masi M,Pinet E,Pagès JM

更新日期：2020-05-21 00:00:00

abstract：:We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： Calvo E,Pastor FJ,Rodríguez MM,Pujol I,Guarro J

更新日期：2010-10-01 00:00:00

abstract：:The in vitro potency and in vivo efficacy of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae were investigated by pharmacokinetic studies with M. pneumoniae-infected hamsters. By using fluoroquinolones, macrolides, and tetracyclines as references, Q-35 was found to possess the greatest mycoplasmacidal activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gohara Y,Arai S,Akashi A,Kuwano K,Tseng CC,Matsubara S,Matumoto M,Furudera T

更新日期：1993-09-01 00:00:00

abstract：:Amoxycillin was significantly more active than ampicillin in the treatment of intraperitoneal mouse infections when administered by oral and parenteral routes, although the causal bacteria were equally susceptible in vitro to the two penicillins. Amoxycillin produced higher antibiotic blood concentrations in mice than...

journal_title：Antimicrobial agents and chemotherapy

authors： Comber KR,Osborne CD,Sutherland R

更新日期：1975-02-01 00:00:00

abstract：:The direct or indirect interactions that antifungals have with the host immune response may play a significant role in defining their activity in vivo. However, the impact that acquired antifungal resistance has on the immunopharmacologic activity of antifungals is not well described. We assessed the immunopharmacolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Beyda ND,Liao G,Endres BT,Lewis RE,Garey KW

更新日期：2015-09-01 00:00:00

abstract：:We evaluated phage therapy in experimental infections due to S242, a fatal neonatal meningitis Escherichia coli strain belonging to the worldwide-distributed O25b:H4-ST131 clone that produces extended-spectrum beta-lactamase CTX-M-15. A lytic phage, EC200(PP), active against S242, was isolated from environmental water...

journal_title：Antimicrobial agents and chemotherapy

authors： Pouillot F,Chomton M,Blois H,Courroux C,Noelig J,Bidet P,Bingen E,Bonacorsi S

更新日期：2012-07-01 00:00:00

abstract：:Toxoplasma gondii enters host cells via an active, self-driven process to fulfill its need for intracellular replication and survival. Successful host cell invasion is governed by sequential release of secretory proteins from three specialized organelles, including the micronemes, which contribute adhesive proteins ne...

journal_title：Antimicrobial agents and chemotherapy

authors： Teo CF,Zhou XW,Bogyo M,Carruthers VB

更新日期：2007-02-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepa...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes E,Salio M,Cerundolo V,Medlin J,Murphy S,Dusheiko G,Klenerman P

更新日期：2004-09-01 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:The antimicrobial activity of carumonam (formerly RO-17-2301), a monocyclic beta-lactam antibiotic, was compared with those of aztreonam, cefotaxime, cefoperazone, ceftazidime, piperacillin, and gentamicin against 455 bacterial isolates. Carumonam did not possess activity against gram-positive cocci and was generally ...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith BR,LeFrock JL,McCloskey RV,Donato JB,Weber SJ,Joseph WS

更新日期：1986-02-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:Candida albicans and Staphylococcus aureus form vigorous polymicrobial biofilms in serum, which may serve as the source of coinfection in patients. More importantly, S. aureus is highly resistant to vancomycin during polymicrobial biofilm formation, with no decreases in bacterial viability observed with up to 1,600 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2010-09-01 00:00:00

abstract：:Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhatt S,Mehta P,Chen C,Daines DA,Mermel LA,Chen HL,Kong MG

更新日期：2018-07-27 00:00:00

abstract：:We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not impr...

journal_title：Antimicrobial agents and chemotherapy

authors： Ibrahim AS,Gebremariam T,Schwartz JA,Edwards JE Jr,Spellberg B

更新日期：2009-02-01 00:00:00

abstract：:Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus disease. We therefore...

journal_title：Antimicrobial agents and chemotherapy

authors： Mellors JW,Bazmi HZ,Schinazi RF,Roy BM,Hsiou Y,Arnold E,Weir J,Mayers DL

更新日期：1995-05-01 00:00:00

abstract：:As a relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established, nelfinavir pharmacokinetics was investigated in order to optimize the individual treatment schedule in a pediatric population. A population pharmacokinetic model was developed to describe the concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirt D,Urien S,Jullien V,Firtion G,Rey E,Pons G,Blanche S,Treluyer JM

更新日期：2006-03-01 00:00:00

abstract：:Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Prunier AL,Malbruny B,Tandé D,Picard B,Leclercq R

更新日期：2002-09-01 00:00:00

abstract：:One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan CS,Morgan SL,Jordan AB,Smith CW,Sutton JP,Gangemi JD

更新日期：1984-01-01 00:00:00

abstract：:Ciprofloxacin is active in vitro against most bacteria that cause peritonitis associated with peritoneal dialysis. We compared the effects of pH (5.5 and 7.4) and medium (dialysis fluid) on the bactericidal activity of ciprofloxacin, tobramycin, vancomycin plus rifampin, and rifampin against Pseudomonas aeruginosa, Es...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormick EM,Echols RM

更新日期：1987-04-01 00:00:00

abstract：:Candida lusitaniae is usually susceptible to echinocandins. Beta-1,3-glucan synthase encoded by FKS genes is the target of echinocandins. A few missense mutations in the C. lusitaniae FKS1 hot spot 1 (HS1) have been reported. We report here the rapid emergence of antifungal resistance in C. lusitaniae isolated during ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asner SA,Giulieri S,Diezi M,Marchetti O,Sanglard D

更新日期：2015-12-01 00:00:00