In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae.

abstract：:In vitro selection of mutants with decreased susceptibility to ertapenem was performed using Escherichia coli and Klebsiella pneumoniae clinical strains producing either the bla(CTX-M-2), bla(CTX-M-3), bla(CTX-M-9), or bla(CTX-M-15) gene. Frequencies of mutants with decreased susceptibilities to ertapenem were similar...

journal_title：Antimicrobial agents and chemotherapy

authors： Girlich D,Poirel L,Nordmann P

更新日期：2009-02-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:Bacteriophage therapy of bacterial infections has received renewed attention owing to the increasing prevalence of antibiotic-resistant pathogens. A side effect of many antibiotics as well as of phage therapy with lytic phage is the release of cell wall components, e.g., endotoxins of gram-negative bacteria, which med...

journal_title：Antimicrobial agents and chemotherapy

authors： Hagens S,Habel A,von Ahsen U,von Gabain A,Bläsi U

更新日期：2004-10-01 00:00:00

abstract：:This work in conjunction with the results presented in an earlier report (M. A. Purdy and K. L. Yielding, Antimicrob. Agents Chemother. 10:182--184, 1976) showed the following. (i) Nalidixic acid and novobiocin could inhibit post-ultraviolet and post-X-ray survival, implicating gyrase function in deoxyribonucleic acid...

journal_title：Antimicrobial agents and chemotherapy

authors： Purdy MA,Yielding KL

更新日期：1979-09-01 00:00:00

abstract：:Antimicrobial liquids and foams were applied to the hands to determine their virucidal activity against rhinoviruses. Dilute solutions (1%) of iodine in ethyl alcohol or in water were most effective in causing inactivation of rhinovirus when applied immediately after viral contamination. Iodine also had a residual vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Hendley JO,Mika LA,Gwaltney JM Jr

更新日期：1978-11-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also...

journal_title：Antimicrobial agents and chemotherapy

authors： Tullus K,Berglund B,Burman LG

更新日期：1990-02-01 00:00:00

abstract：:Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus Here, we explored the MIC variability in more detail and prospectively investigated the susceptibili...

journal_title：Antimicrobial agents and chemotherapy

authors： Astvad KMT,Jørgensen KM,Hare RK,Datcu R,Arendrup MC

更新日期：2020-12-16 00:00:00

abstract：:The current treatment of chronic hepatitis C is based on pegylated alpha interferon (PEG-IFN-α) and ribavirin. The aim of this study was to identify biological and clinical variables related to IFN therapy that could predict patient outcome. The study enrolled 47 patients treated with PEG-IFN and ribavirin combined th...

journal_title：Antimicrobial agents and chemotherapy

authors： François C,Coulouarn C,Descamps V,Castelain S,Brochot E,Baron A,Duchaussoy I,Capron D,Nguyen-Khac E,Duverlie G

更新日期：2012-02-01 00:00:00

abstract：:The CcrA beta-lactamase from Bacteroides fragilis TAL3636 was cloned into Escherichia coli and purified from inclusion bodies. This group 3 metalloenzyme hydrolyzed most beta-lactam antibiotics, including cephamycins and carbapenems. Following inhibition by chelators, enzyme activity was recovered with the cations Zn2...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Rasmussen BA,Bush K

更新日期：1992-05-01 00:00:00

abstract：:Aspergillus fumigatus is a leading cause of death in immunocompromised patients and a frequent colonizer of the respiratory tracts of asthma and cystic fibrosis (CF) patients. Biofilms enable bacteria and yeasts to persist in infections and can contribute to antimicrobial resistance. We investigated the ability of A. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seidler MJ,Salvenmoser S,Müller FM

更新日期：2008-11-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Salabi MI,de Koning HP

更新日期：2005-09-01 00:00:00

abstract：:Vaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, do...

journal_title：Antimicrobial agents and chemotherapy

authors： Griffith DC,Loutit JS,Morgan EE,Durso S,Dudley MN

更新日期：2016-09-23 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:The physicochemical constants and some structural parameters (topological, steric, and electronic) of eight third-generation monofluorate quinolones (six uncommercialized and two used clinically [ciprofloxacin and enrofloxacin]) were determined: pKa, intrinsic solubility (S0), chromatographic capacity factor, partitio...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano E,Calpena AC,Garrigues TM,Freixas J,Domenech J,Moreno J

更新日期：1997-09-01 00:00:00

abstract：:Although information about the efficacy and safety experience with caspofungin at 50 mg/m(2) daily is available for children and adolescents, the dosing regimen in infants and toddlers 3 to 24 months of age has yet to be established. We studied the pharmacokinetics and safety of caspofungin at 50 mg/m(2) once daily in...

journal_title：Antimicrobial agents and chemotherapy

authors： Neely M,Jafri HS,Seibel N,Knapp K,Adamson PC,Bradshaw SK,Strohmaier KM,Sun P,Bi S,Dockendorf MF,Stone JA,Kartsonis NA

更新日期：2009-04-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:Because of the rising incidence of failures in the treatment of oropharyngeal candidosis in the case of severely immunosuppressed patients (mostly human immunodeficiency virus [HIV]-infected patients), there is need for the development of new, more effective agents and/or compounds that support the activity of the com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuipers ME,de Vries HG,Eikelboom MC,Meijer DK,Swart PJ

更新日期：1999-11-01 00:00:00

abstract：:Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of conditions applying to in...

journal_title：Antimicrobial agents and chemotherapy

authors： Parapini S,Olliaro P,Navaratnam V,Taramelli D,Basilico N

更新日期：2015-07-01 00:00:00

abstract：:The objective of this study was to determine the population pharmacokinetic parameters of levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at the University Hospital in Vitória, Brazil, participated. Subjects received multiple doses of one drug (levoflo...

journal_title：Antimicrobial agents and chemotherapy

authors： Peloquin CA,Hadad DJ,Molino LP,Palaci M,Boom WH,Dietze R,Johnson JL

更新日期：2008-03-01 00:00:00

abstract：:A clinical isolate of Enterobacter cloacae, strain NOR-1, exhibited resistance to imipenem and remained susceptible to extended-spectrum cephalosporins. Clavulanic acid partially restored the susceptibility of the strain to imipenem. Two beta-lactamases with isoelectric points (pI) of 6.9 and > 9.2 were detected in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Nordmann P,Mariotte S,Naas T,Labia R,Nicolas MH

更新日期：1993-05-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola...

journal_title：Antimicrobial agents and chemotherapy

authors： Ekins S,Madrid PB

更新日期：2020-04-21 00:00:00

abstract：:Since beta-lactam antibiotics have concentration-independent killing, bacterial eradication is a function of the time the serum drug concentration remains above the drug's MIC (T > MIC). We compared the serum bactericidal titers (SBTs) of ceftazidime given by continuous infusion (CI) or by intermittent bolus dosing (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicolau DP,Nightingale CH,Banevicius MA,Fu Q,Quintiliani R

更新日期：1996-01-01 00:00:00

abstract：:Replication of measles virus in BSC cells was studied in the presence of enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether), a commonly used volatile anesthetic agent, and its isomer, isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). At clinical concentrations of the anesthetics (up to 4%), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knight PR,Nahrwold ML,Bedows E

更新日期：1981-09-01 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00