Antimicrobial prophylaxis for major head and neck surgery in cancer patients.


:A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic treatment (surgery, chemotherapy, and radiotherapy) or tracheostomy, and the various types of surgery including radical neck dissection. The wound infection rate was 10% in the group of patients receiving clindamycin plus amikacin and 36% in the group receiving ticarcillin plus clavulanic acid (P less than 0.05). Initiation of systemic antibiotic therapy within 15 days of surgery was necessary for 20 and 45% of these patients, respectively (P less than 0.05). The distribution of microorganisms causing wound infections was comparable in both groups, except for anaerobes, which were isolated predominantly from patients who had received ticarcillin plus clavulanic acid.


Gerard M,Meunier F,Dor P,Andry G,Chantrain G,Van der Auwera P,Daneau D,Klastersky J




Has Abstract


1988-10-01 00:00:00












  • Piperacillin plus vancomycin in the therapy of febrile episodes in cancer patients.

    abstract::Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

    更新日期:1984-09-01 00:00:00

  • Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.

    abstract::This paper reports an evaluation of a melamino nitroheterocycle, a potential lead for further development as an agent against human African trypanosomiasis (HAT). Studies on its efficacy, physicochemical and biopharmaceutical properties, and potential for toxicity are described. The compound previously had been shown ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Giordani F,Buschini A,Baliani A,Kaiser M,Brun R,Barrett MP,Pellacani C,Poli P,Gilbert IH

    更新日期:2014-10-01 00:00:00

  • Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.

    abstract::Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

    更新日期:2003-12-01 00:00:00

  • Role of Interleukin-12 in Protection against Pulmonary Infection with Methicillin-Resistant Staphylococcus aureus.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen associated with nosocomial pneumonia and is an increasing threat for severe community-acquired pneumonia. We have now investigated the role of interleukin-12 (IL-12) in protective immunity against lung infection with MRSA. The importance of IL-12 ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nguyen QT,Furuya Y,Roberts S,Metzger DW

    更新日期:2015-10-01 00:00:00

  • In vitro activity of trovafloxacin against Chlamydia pneumoniae.

    abstract::The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Roblin PM,Kutlin A,Hammerschlag MR

    更新日期:1997-09-01 00:00:00

  • Inhibition of Rift Valley fever virus replication and perturbation of nucleocapsid-RNA interactions by suramin.

    abstract::Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ellenbecker M,Lanchy JM,Lodmell JS

    更新日期:2014-12-01 00:00:00

  • Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli.

    abstract::Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Molina-Quiroz RC,Lazinski DW,Camilli A,Levy SB

    更新日期:2016-10-21 00:00:00

  • Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand.

    abstract::Desbutyl-benflumetol (DBB) is a novel antimalarial compound closely related to benflumetol (lumefantrine), of which it is a putative metabolite. The in vitro response of Plasmodium falciparum to DBB was studied in Mae Hong Son and Mae Sot, in northwest Thailand, in 1997 and 1998. In total, 155 fresh isolates were succ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Noedl H,Allmendinger T,Prajakwong S,Wernsdorfer G,Wernsdorfer WH

    更新日期:2001-07-01 00:00:00

  • Evaluating 5-Nitrothiazoles as Trypanocidal Agents.

    abstract::The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: O'Shea IP,Shahed M,Aguilera-Venegas B,Wilkinson SR

    更新日期:2015-11-23 00:00:00

  • Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.

    abstract::Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, each comprising eight healthy volunteers who received the following dose...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krueger WA,Bulitta J,Kinzig-Schippers M,Landersdorfer C,Holzgrabe U,Naber KG,Drusano GL,Sörgel F

    更新日期:2005-05-01 00:00:00

  • Effect of N, N'-dicyclohexylcarbodiimide and nigericin on Staphylococcus aureus susceptibility to gentamicin.

    abstract::The abilities of the H+-ATPase inhibitor N, N'-dicyclohexylcarbodiimide and the antibiotic ionophore nigericin to enhance the bactericidal effect of subinhibitory concentrations of gentamicin in two strains of Staphylococcus aureus were studied. Each compound significantly increased both gentamicin uptake and killing....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mandel LJ,Eisenberg ES,Simkin NJ,Miller MH

    更新日期:1983-09-01 00:00:00

  • Restrictive Streptomycin Resistance Mutations Decrease the Formation of Attaching and Effacing Lesions in Escherichia coli O157:H7 Strains.

    abstract::Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

    更新日期:2013-09-01 00:00:00

  • Penetration of cefpiramide and cefazolin into peritoneal capsular fluid in rabbits.

    abstract::Penetration of cefpiramide and cefazolin into a specific extravascular fluid was measured with rabbits bearing capsules in the peritoneal cavity. A general feature of slow accumulation and elimination of drugs from extravascular sites having low surface area/volume ratios has also been observed in this study. The caps...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matsui H,Okuda T

    更新日期:1988-01-01 00:00:00

  • Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria.

    abstract::Preclinical animal models informing antimalarial drug development are scarce. We have used asexual erythrocytic Plasmodium cynomolgi infections of rhesus macaques to model Plasmodium vivax during preclinical development of compounds targeting parasite phospholipid synthesis. Using this malaria model, we accumulated da...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kocken CH,Remarque EJ,Dubbeld MA,Wein S,van der Wel A,Verburgh RJ,Vial HJ,Thomas AW

    更新日期:2009-02-01 00:00:00

  • In vitro activities of ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, and rifampin against fully susceptible and moderately penicillin-resistant Neisseria meningitidis.

    abstract::Moderately penicillin-resistant Neisseria meningitidis was responsible for an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada in 1993. We tested fully susceptible and moderately resistant strains of N. meningitidis against ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, penicillin, and ri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Blondeau JM,Yaschuk Y

    更新日期:1995-11-01 00:00:00

  • Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity.

    abstract::Nephrotoxicity is the main complication of gentamicin (GM) treatment. GM induces renal damage by overproduction of reactive oxygen species and inflammation in proximal tubular cells. Phenolic compounds from ginger, called gingerols, have been demonstrated to have antioxidant and anti-inflammatory effects. We investiga...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rodrigues FA,Prata MM,Oliveira IC,Alves NT,Freitas RE,Monteiro HS,Silva JA,Vieira PC,Viana DA,Libório AB,Havt A

    更新日期:2014-01-01 00:00:00

  • Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.

    abstract::The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

    更新日期:2010-05-01 00:00:00

  • Unusual susceptibility of a multidrug-resistant yeast strain to peptidic antifungals.

    abstract::The susceptibility of Saccharomyces cerevisiae JG436 multidrug transporter deletion mutant, Deltapdr5, to several antifungal agents was compared to that of JG436-derived JGCDR1 and JGCaMDR1 transformants, harboring the CDR1 and CaMDR1 genes, encoding the main drug-extruding membrane proteins of Candida albicans. The J...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Milewski S,Mignini F,Prasad R,Borowski E

    更新日期:2001-01-01 00:00:00

  • Action of polymyxin B on bacterial membranes: morphological changes in the cytoplasm and in the outer membrane of Salmonella typhimurium and Escherichia coli B.

    abstract::Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Schindler PR,Teuber M

    更新日期:1975-07-01 00:00:00

  • Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.

    abstract::Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquin...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Betuela I,Bassat Q,Kiniboro B,Robinson LJ,Rosanas-Urgell A,Stanisic D,Siba PM,Alonso PL,Mueller I

    更新日期:2012-04-01 00:00:00

  • Amprenavir and efavirenz pharmacokinetics before and after the addition of nelfinavir, indinavir, ritonavir, or saquinavir in seronegative individuals.

    abstract::Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). S...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Morse GD,Rosenkranz S,Para MF,Segal Y,Difrancesco R,Adams E,Brizz B,Yarasheski KE,Reichman RC

    更新日期:2005-08-01 00:00:00

  • Antifungal application of nonantifungal drugs.

    abstract::Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

    更新日期:2014-01-01 00:00:00

  • Bactericidal action of dapsone against Mycobacterium leprae in mice.

    abstract::Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Levy L

    更新日期:1976-04-01 00:00:00

  • Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen.

    abstract::A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jung H,Medina R,Castro N,Corona T,Sotelo J

    更新日期:1997-06-01 00:00:00

  • Cefotaxime: in vitro activity and tentative interpretive standards for disk susceptibility testing.

    abstract::Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

    更新日期:1980-07-01 00:00:00

  • Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing.

    abstract::A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncomm...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cuenca-Estrella M,Gomez-Lopez A,Cuesta I,Zaragoza O,Mellado E,Rodriguez-Tudela JL,Antifungal Subcommittee of European Committee on Antimicrobial Susceptibility Testing.

    更新日期:2011-04-01 00:00:00

  • Cinoxacin: effectiveness against experimental pyelonephritis in rats.

    abstract::The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mir...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Holmes DH,Ensminger PW,Gordee RS

    更新日期:1974-10-01 00:00:00

  • Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains.

    abstract::Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

    更新日期:2008-01-01 00:00:00

  • Inhibition of filamentation can be used to treat disseminated candidiasis.

    abstract::Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

    更新日期:2006-10-01 00:00:00

  • Comparative activities of Bay n7133, ICI 153,066, and ketoconazole in murine cryptococcosis.

    abstract::Two new antifungal triazoles, BAY n7133 and ICI 153,066, were compared with ketoconazole in treatment of mice challenged intraperitoneally with Cryptococcus neoformans. At high challenge doses, thymus-containing normal mice had prolonged survival after treatment with BAY n7133. Athymic mice, which have severely defici...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Graybill JR,Kaster SR,Drutz DJ

    更新日期:1983-12-01 00:00:00