Abstract:
:We developed a multiplex PCR assay capable of identifying two capsular polysaccharide synthesis sequence types (sequence type 258 [ST258] cps-1 and cps-2) in epidemic Klebsiella pneumoniae ST258 strains. The assay performed with excellent sensitivity (100%) and specificity (100%) for identifying cps types in 60 ST258 K. pneumoniae sequenced isolates. The screening of 419 ST258 clonal isolates revealed a significant association between cps type and K. pneumoniae carbapenemase (KPC) variant: cps-1 is largely associated with KPC-2, while cps-2 is primarily associated with KPC-3.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Chen L,Chavda KD,Findlay J,Peirano G,Hopkins K,Pitout JD,Bonomo RA,Woodford N,DeLeo FR,Kreiswirth BNdoi
10.1128/AAC.02673-14subject
Has Abstractpub_date
2014-07-01 00:00:00pages
4196-9issue
7eissn
0066-4804issn
1098-6596pii
AAC.02673-14journal_volume
58pub_type
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