Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program.

abstract：:To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to that of praziquantel against both adult and juvenile Schistosoma ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Panic G,Ruf MT,Keiser J

更新日期：2017-11-22 00:00:00

abstract：:Although ampicillin has been suggested as a useful agent for the treatment of nocardiosis in man, little is known regarding the presence of beta-lactamase in Nocardia or its possible role in determining resistance to ampicillin and the other beta-lactam antibiotics. We have evaluated 55 isolates of Nocardia for suscep...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Vance P,Weissfeld A,Martin RR

更新日期：1978-11-01 00:00:00

abstract：:RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC90s of RBx 11760 and linezolid against Staphylococcus aureus were 2 and 4 mg/liter, against Staphylococcus epidermidis were 0.5 and 2 mg/liter, and against Enterococcus were 1 and 4 mg/liter, respecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Barman TK,Kumar M,Mathur T,Chaira T,Ramkumar G,Kalia V,Rao M,Pandya M,Yadav AS,Das B,Upadhyay DJ,Hamidullah,Konwar R,Raj VS,Singh H

更新日期：2016-11-21 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes serious illness (lower respiratory illness) in preterm infants. RSV antibody-enriched immunoglobulin (RSVIG) that was lyophilized (LYO) protected against RSV lower respiratory illness. The Food and Drug Administration now requires an additional viral inactivation step (VI). We ...

journal_title：Antimicrobial agents and chemotherapy

authors： Groothuis JR,Simoes EA,Lehr MV,Kramer AA,Hemming VG,Rodriguez WJ,Arrobio J,Welliver RC,Siber GR

更新日期：1995-03-01 00:00:00

abstract：:In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibil...

journal_title：Antimicrobial agents and chemotherapy

authors： Heine HS,Hershfield J,Marchand C,Miller L,Halasohoris S,Purcell BK,Worsham PL

更新日期：2015-04-01 00:00:00

abstract：:Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) vi...

journal_title：Antimicrobial agents and chemotherapy

authors： Borowski P,Lang M,Haag A,Schmitz H,Choe J,Chen HM,Hosmane RS

更新日期：2002-05-01 00:00:00

abstract：:The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaehde U,Sörgel F,Stephan U,Schunack W

更新日期：1994-05-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen and leading cause of health care-associated infections. Daily chlorhexidine gluconate (CHG) bathing of patients is generally regarded as an effective strategy to reduce the occurrence of health care-associated infections. It is likely that E. faecalis is frequently ex...

journal_title：Antimicrobial agents and chemotherapy

authors： Li FJ,Palmer KL

更新日期：2018-05-25 00:00:00

abstract：:As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent inhibition of ergoste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanden Bossche H,Marichal P,Le Jeune L,Coene MC,Gorrens J,Cools W

更新日期：1993-10-01 00:00:00

abstract：:Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang GW,Brunel JM,Bolla JM,Van Bambeke F

更新日期：2020-12-14 00:00:00

abstract：:The MICs for 90% of the organisms tested (MIC90S) of 11 antibiotics against 24 clinical isolates of Actinobacillus actinomycetemcomitans were determined by the MIC 2000 system. The lowest MIC90S (16 micrograms/ml) were observed with ceftriaxone and rifampin. The next lowest MIC90S were found with cephapirin, tetracycl...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Shulman D,Shulman ST,Glogowski WG

更新日期：1986-01-01 00:00:00

abstract：:A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range of antimalarial drugs. Its sensitivity allowed the use of parasite densities as low as 200 parasites/microl of blood. Be...

journal_title：Antimicrobial agents and chemotherapy

authors： Brockman A,Singlam S,Phiaphun L,Looareesuwan S,White NJ,Nosten F

更新日期：2004-04-01 00:00:00

abstract：:Here, we report on the anti-influenza virus activity of the mannose-binding agents, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), and the (N-acetylglucosamine)n-specific Urtica dioica agglutinin (UDA). These carbohydrate-binding agents (CBA) strongly inhibited various influenza A(H1N1), A...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanderlinden E,Van Winkel N,Naesens L,Van Damme EJM,Persoons L,Schols D

更新日期：2020-12-07 00:00:00

abstract：:Previously, we reported potent activity of a novel spiropyrimidinetrione, zoliflodacin, against N. gonorrhoeae isolates from symptomatic men in Nanjing, China, collected in 2013. Here, we investigated trends of susceptibilities of zoliflodacin in 986 isolates collected from men between 2014 and 2018. N. gonorrhoeae is...

journal_title：Antimicrobial agents and chemotherapy

authors： Le W,Su X,Lou X,Li X,Gong X,Wang B,Genco CA,Mueller JP,Rice PA

更新日期：2020-12-14 00:00:00

abstract：:We isolated mutant YM644, which showed elevated resistance to norfloxacin, ethidium bromide, acriflavine, and rhodamine 6G, from Pseudomonas aeruginosa YM64, a strain that lacks four major multidrug efflux pumps. The genes responsible for the resistance were mexHI-opmD. Elevated ethidium extrusion was observed with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sekiya H,Mima T,Morita Y,Kuroda T,Mizushima T,Tsuchiya T

更新日期：2003-09-01 00:00:00

abstract：:R plasmids from chloramphenicol-resistant salmonella from Ontario are shown to belong to the H(2) incompatibility subgroup and to mediate a broad-spectrum, phage inhibition function. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Grant RB

更新日期：1976-10-01 00:00:00

abstract：:The pharmacokinetics and distribution in tissue of several novel triazole antifungal agents were studied in different animal species in order to select an appropriate lead compound. The purpose of the study was also to determine species differences in pharmacokinetics for SYN azoles to select the most appropriate spec...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan JK,Montaseri H,Poglod M,Bu HZ,Zuo Z,Salama SM,Daneshtalab M,Micetich RG

更新日期：2000-04-01 00:00:00

abstract：:Two hundred and fifty-seven ampicillin-resistant clinical isolates of Haemophilus influenzae were tested by disk diffusion and MIC determination for susceptibility to aztreonam, imipenem, and amoxycillin combined with clavulanate. The modal MICs and MICs for 50 and 90% of isolates of all three antimicrobial agents for...

journal_title：Antimicrobial agents and chemotherapy

authors： Powell M,Williams JD

更新日期：1987-12-01 00:00:00

abstract：:The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Long L,Hager C,Ghannoum M

更新日期：2016-03-25 00:00:00

abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

更新日期：2019-07-25 00:00:00

abstract：:An extracellular inhibitory substance produced by the marine Alteromonas strain P-31 (NCMB 2144) was isolated and purified. The inhibitor was a macromolecule with a molecular weight of 90,000 estimated by Sephadex G-100 chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The inhibitory activi...

journal_title：Antimicrobial agents and chemotherapy

authors： Barja JL,Lemos ML,Toranzo AE

更新日期：1989-10-01 00:00:00

abstract：:The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies. Parasitic pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan WJ Jr,Dixon SE,Li C,Striepen B,Queener SF

更新日期：2005-06-01 00:00:00

abstract：:Five patients with chronic hepatitis B were treated with 8-day courses of leukocyte (alpha) interferon (5 X 10(6) U/day) and with 8-day courses of recombinant fibroblast (betaser) interferon at dosages of 5 X 10(6), 35 X 10(6), and 105 X 10(6) U/day. Inhibition of hepatitis B virus replication as evidenced by a decrea...

journal_title：Antimicrobial agents and chemotherapy

authors： Eisenberg M,Rosno S,Garcia G,Konrad MW,Gregory PB,Robinson WS,Merigan TC

更新日期：1986-01-01 00:00:00

abstract：:We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

更新日期：2020-12-14 00:00:00

abstract：:Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Molina-Quiroz RC,Lazinski DW,Camilli A,Levy SB

更新日期：2016-10-21 00:00:00

abstract：:Polymyxins are increasingly used as a last-resort class of antibiotics against extensively drug-resistant (XDR) Gram-negative bacteria. However, resistance to polymyxins can emerge with monotherapy. As nephrotoxicity is the major dose-limiting factor for polymyxin monotherapy, dose escalation to suppress the emergence...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin YW,Yu HH,Zhao J,Han ML,Zhu Y,Akter J,Wickremasinghe H,Walpola H,Wirth V,Rao GG,Forrest A,Velkov T,Li J

更新日期：2018-05-25 00:00:00

abstract：:Azole antifungal resistance in Aspergillus fumigatus is a worldwide concern. As in most public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for filamentous fungi at our institution. A 4-year retrospective azole antifungal resistance screening revealed two azole-resistant A. fumigatu...

journal_title：Antimicrobial agents and chemotherapy

authors： Pontes L,Beraquet CAG,Arai T,Pigolli GL,Lyra L,Watanabe A,Moretti ML,Schreiber AZ

更新日期：2020-02-21 00:00:00

abstract：:The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitr...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Shea IP,Shahed M,Aguilera-Venegas B,Wilkinson SR

更新日期：2015-11-23 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00