Evaluating 5-Nitrothiazoles as Trypanocidal Agents.

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhatt S,Mehta P,Chen C,Daines DA,Mermel LA,Chen HL,Kong MG

更新日期：2018-07-27 00:00:00

abstract：:A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdon R,Polianski J,Gaudebout C,Marche C,Garry L,Pocidalo JJ

更新日期：1994-07-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Various doses of amphotericin B encapsulated into unilamellar vesicles of 0.1 micron diameter (lip-AMB) (1.0 to 20.0 mg/kg of body weight) were compared with free amphotericin B (AMB) (0.5 to 2.0 mg/kg of body weight) in a murine model of disseminated candidiasis. CD2F1 mice injected intravenously with 3 x 10(5) Candi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gondal JA,Swartz RP,Rahman A

更新日期：1989-09-01 00:00:00

abstract：:Patients (n = 409) with severe skin and soft tissue infections (SSTIs) were randomized to receive clinafloxacin or piperacillin-tazobactam (plus optional vancomycin for methicillin-resistant cocci), administered intravenously, with the option to switch to oral medication. Most patients had cellulitis, wound infections...

journal_title：Antimicrobial agents and chemotherapy

authors： Siami G,Christou N,Eiseman I,Tack KJ,Severe Skin and Soft Tissue Infections Study Group.

更新日期：2001-02-01 00:00:00

abstract：:The aim of this study was to characterize a novel extended-spectrum beta-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine residue at posi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Celenza G,De Santis F,Pellegrini C,Forcella C,Rossolini GM,Stefani S,Amicosante G

更新日期：2008-03-01 00:00:00

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00

abstract：:The antileishmanial efficacies of four proprietary amphotericin B (AmB) formulations (Fungizone, AmBisome, Abelcet, and Amphocil) and an experimental nonionic surfactant vesicle (NIV) formulation were compared in a murine model of acute visceral leishmaniasis. By a multiple-dosing regimen, groups of Leishmania donovan...

journal_title：Antimicrobial agents and chemotherapy

authors： Mullen AB,Carter KC,Baillie AJ

更新日期：1997-10-01 00:00:00

abstract：:In this report, we describe a new method to measure intracellular zidovudine triphosphate (ZDV-TP) levels in peripheral blood mononuclear cells (PBMCs) from patients treated with ZDV by utilizing inhibition of human immunodeficiency virus type 1 reverse transcriptase activity by ZDV-TP. Intracellular levels of ZDV-TP ...

journal_title：Antimicrobial agents and chemotherapy

authors： Robbins BL,Rodman J,McDonald C,Srinivas RV,Flynn PM,Fridland A

更新日期：1994-01-01 00:00:00

abstract：:The antimicrobial activity of carumonam (formerly RO-17-2301), a monocyclic beta-lactam antibiotic, was compared with those of aztreonam, cefotaxime, cefoperazone, ceftazidime, piperacillin, and gentamicin against 455 bacterial isolates. Carumonam did not possess activity against gram-positive cocci and was generally ...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith BR,LeFrock JL,McCloskey RV,Donato JB,Weber SJ,Joseph WS

更新日期：1986-02-01 00:00:00

abstract：:The kinetics of the entry of three aminoglycosides into inner-ear tissues of the guinea pig after acute and chronic administration were compared: gentamicin toxic to the cochlea and the vestibule, amikacin preferentially cochleotoxic, and netilmicin of low ototoxic liability. During constant intravenous infusion, leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Dulon D,Aran JM,Zajic G,Schacht J

更新日期：1986-07-01 00:00:00

abstract：:Strains of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 (DT104) and S. enterica serovar Agona (Agona) have been found to harbor Salmonella genomic island 1 (SGI1), a 43-kb genomic region that contains many of the drug resistance genes. Such strains are resistant to ampicillin (pse-1), chlorampheni...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd D,Cloeckaert A,Chaslus-Dancla E,Mulvey MR

更新日期：2002-06-01 00:00:00

abstract：:Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The objective of this study was to characterize the dose-response relationship of ceftaroline fosamil against S. aureus in an immunocompromised murine pneumonia model, as ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhalodi AA,Crandon JL,Biek D,Nicolau DP

更新日期：2012-12-01 00:00:00

abstract：:Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradi...

journal_title：Antimicrobial agents and chemotherapy

authors： Arroyo J,Medoff G,Kobayashi GS

更新日期：1977-01-01 00:00:00

abstract：:The antileprosy effect of rifampin was evaluated by a newly developed rapid in vitro assay wherein 31 human-derived strains and 1 armadillo-derived strain of Mycobacterium leprae were maintained for 2 and 3 weeks, respectively, in murine and human macrophages in the presence of [3H]thymidine. Of these strains, 27 show...

journal_title：Antimicrobial agents and chemotherapy

authors： Mittal A,Seshadri PS,Prasad HK,Sathish M,Nath I

更新日期：1983-10-01 00:00:00

abstract：:High-level resistance to quinolones has previously been shown to occur in Campylobacter spp. both in vitro and in patients treated with quinolones. We have selected isolates that are resistant to quinolones by plating cells from a susceptible C. jejuni strain, UA535, on medium containing nalidixic acid at 32 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Martin BA

更新日期：1991-05-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutt M,Khuller GK

更新日期：2001-01-01 00:00:00

abstract：:The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

更新日期：2011-09-01 00:00:00

abstract：:Ro 09-0179 (4',5-dihydroxy-3,3',7-trimethoxyflavone), isolated from a Chinese medicinal herb, was found to have potent antiviral activity. It selectively inhibited the replication of human picornaviruses, such as rhinoviruses and coxsackieviruses in tissue culture, but not other DNA and RNA viruses. Ro 09-0298 (4',5-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishitsuka H,Ohsawa C,Ohiwa T,Umeda I,Suhara Y

更新日期：1982-10-01 00:00:00

abstract：:The activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. All strains were recent clinical isolates from community hospitals. All agents tested showed good activity against Bacteroides fragi...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1985-02-01 00:00:00

abstract：:Porphyromonas gingivalis is a bacterial pathogen associated with chronic periodontitis that results in destruction of the tooth's supporting tissues. The major virulence determinants of P. gingivalis are its cell surface Arg- and Lys-specific cysteine proteinases, RgpA/B and Kgp. Lactoferrin (LF), an 80-kDa iron-bindi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dashper SG,Pan Y,Veith PD,Chen YY,Toh EC,Liu SW,Cross KJ,Reynolds EC

更新日期：2012-03-01 00:00:00

abstract：:The binding of antibiotics to plasma (serum) proteins through hydrogen bonding can significantly influence the biological characteristics of these drugs. A rapid spectrophotometric assay has been developed that measures the level of free (unbound) penem antibiotic in serum ultrafiltrates. Whole human serum was adjuste...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Subashi TA,Lindner DL

更新日期：1988-02-01 00:00:00

abstract：:While the neuraminidase (NA) inhibitor oseltamivir is currently our first line of defense against a pandemic threat, there is little information about whether in vitro testing can predict the in vivo effectiveness of antiviral treatment. Using a panel of five H5N1 influenza viruses (H5 clades 1 and 2), we determined t...

journal_title：Antimicrobial agents and chemotherapy

authors： Govorkova EA,Ilyushina NA,McClaren JL,Naipospos TS,Douangngeun B,Webster RG

更新日期：2009-07-01 00:00:00

abstract：:The in vitro antifungal activities of two N-aminoacyl derivatives of amphotericin B methyl ester (AME) were compared by tube dilution with those of amphotericin B and AME, using 60 isolates representing 10 yeast species. A total of 70% of the strains were inhibited by concentrations of the N-aminoacyl AME derivatives ...

journal_title：Antimicrobial agents and chemotherapy

authors： Oblack DL,Hewitt WL,Martin WJ

更新日期：1981-01-01 00:00:00

abstract：:Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachmann SP,VandeWalle K,Ramage G,Patterson TF,Wickes BL,Graybill JR,López-Ribot JL

更新日期：2002-11-01 00:00:00

abstract：:The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its penicillinase-negative derivative was investigated in vitro and in a rabbit experimental endocarditis model. Penicillin was sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Fantin B,Pierre J,Castéla-Papin N,Saint-Julien L,Drugeon H,Farinotti R,Carbon C

更新日期：1996-05-01 00:00:00

abstract：:Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizushima T,Matsuo M,Sekimizu K

更新日期：1997-01-01 00:00:00