当前位置： SCI文献检索 > ANTIMICROBIAL AGENTS AND CHEMOTHERAPY期刊下所有文献 > Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in Nanjing, China (2014-2018).

Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in Nanjing, China (2014-2018).

Abstract：

:Previously, we reported potent activity of a novel spiropyrimidinetrione, zoliflodacin, against N. gonorrhoeae isolates from symptomatic men in Nanjing, China, collected in 2013. Here, we investigated trends of susceptibilities of zoliflodacin in 986 isolates collected from men between 2014 and 2018. N. gonorrhoeae isolates were tested for susceptibility to zoliflodacin and seven other antibiotics. Mutations in gyrA, gyrB, parC, parE and mtrR genes were determined by PCR and sequencing. The MICs of zoliflodacin ranged from ≤0.002 to 0.25 mg/L; the overall MIC50s and MIC90s were 0.06 mg/L and 0.125mg/L in 2018, increasing two-fold from 2014. However, the percent of isolates with lower zoliflodacin MICs declined in each year sequentially while the percent with higher MICs increased yearly (P≤0.00001). All isolates were susceptible to spectinomycin but resistant to ciprofloxacin (MIC ≥1 mg/L); 21.2% (209/986) were resistant to azithromycin (≥1 mg/L), 43.4% (428/986) were penicillinase-producing (PPNG), 26.9% (265/986) tetracycline-resistant (TRNG) and 19.4% (191/986) were multi-drug resistant (MDR) isolates. Among 202 isolates tested, all were quinolone resistant with double or triple mutations in gyrA; One hundred ninety three (193/202; 95.5%) also had mutations in parC There were no D429N/A and/or K450T mutations in GyrB identified in the 143 isolates with higher zoliflodacin MICs; a S467N mutation in GyrB was identified in one isolate. We report that zoliflodacin continues to have excellent in vitro activity against clinical gonococcal isolates, including those with high-level resistance to ciprofloxacin, azithromycin and extended spectrum cephalosporins.

journal_name

Antimicrob Agents Chemother

journal_title

Antimicrobial agents and chemotherapy

authors

Le W,Su X,Lou X,Li X,Gong X,Wang B,Genco CA,Mueller JP,Rice PA

doi

10.1128/AAC.00863-20

subject

Has Abstract

pub_date

2020-12-14 00:00:00

eissn

0066-4804

issn

1098-6596

pii

AAC.00863-20

pub_type

杂志文章

相关文献

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY文献大全
  • In vitro activity of A-56619 (difloxacin), A-56620, and other new quinolone antimicrobial agents against genital pathogens.

    abstract：:The in vitro activities of two new carboxyquinolones, A-56619 (difloxacin) and A-56620, were compared with those of ciprofloxacin, norfloxacin, and ofloxacin against genital tract pathogens. All the quinolones were highly active against Neisseria gonorrhoeae. A-56619 had the lowest MICs against Chlamydia trachomatis (...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.30.6.948

    authors： Liebowitz LD,Saunders J,Fehler G,Ballard RC,Koornhof HJ

    更新日期：1986-12-01 00:00:00

  • Systematic review and meta-analysis of antimicrobial treatment effect estimation in complicated urinary tract infection.

    abstract：:Noninferiority trial design and analyses are commonly used to establish the effectiveness of a new antimicrobial drug for treatment of serious infections such as complicated urinary tract infection (cUTI). A systematic review and meta-analysis were conducted to estimate the treatment effects of three potential active ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章,meta分析,评审

    doi：10.1128/AAC.01257-13

    authors： Singh KP,Li G,Mitrani-Gold FS,Kurtinecz M,Wetherington J,Tomayko JF,Mundy LM

    更新日期：2013-11-01 00:00:00

  • Evidence for Inhibition of Topoisomerase 1A by Gold(III) Macrocycles and Chelates Targeting Mycobacterium tuberculosis and Mycobacterium abscessus.

    abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01696-17

    authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

    更新日期：2018-04-26 00:00:00

  • Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation.

    abstract：:Chronic airway infection and inflammation contribute to the progressive loss of lung function and shortened survival of patients with cystic fibrosis (CF). Rhesus theta defensin-1 (RTD-1) is a macrocyclic host defense peptide with antimicrobial and immunomodulatory activities. Combined with favorable preclinical safet...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00154-17

    authors： Bensman TJ,Jayne JG,Sun M,Kimura E,Meinert J,Wang JC,Schaal JB,Tran D,Rao AP,Akbari O,Selsted ME,Beringer PM

    更新日期：2017-07-25 00:00:00

  • An Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase Inhibitors.

    abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00539-19

    authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

    更新日期：2019-07-25 00:00:00

  • The Global Regulatory Cyclic AMP Receptor Protein (CRP) Controls Multifactorial Fluoroquinolone Susceptibility in Salmonella enterica Serovar Typhimurium.

    abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01666-17

    authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

    更新日期：2017-10-24 00:00:00

  • In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin.

    abstract：:Antistaphylococcal activity of the novel chimeric endolysin PRF-119 was evaluated with the microdilution method. The MIC(50) and MIC(90) of 398 methicillin-susceptible Staphylococcus aureus isolates were 0.098 μg/ml and 0.391 μg/ml, respectively (range, 0.024 to 0.780 μg/ml). Both the MIC(50) and MIC(90) values of 776...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00217-11

    authors： Idelevich EA,von Eiff C,Friedrich AW,Iannelli D,Xia G,Peters G,Peschel A,Wanninger I,Becker K

    更新日期：2011-09-01 00:00:00

  • In vitro synergy of colistin combinations against colistin-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae isolates.

    abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.05996-11

    authors： Vidaillac C,Benichou L,Duval RE

    更新日期：2012-09-01 00:00:00

  • Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

    abstract：:TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In Escherichia coli cel...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.06187-11

    authors： Grossman TH,Starosta AL,Fyfe C,O'Brien W,Rothstein DM,Mikolajka A,Wilson DN,Sutcliffe JA

    更新日期：2012-05-01 00:00:00

  • Effects of dihydrostreptomycin on ribosome function in vivo: lack of correlation between changes in ribosome patterns and growth.

    abstract：:In vivo treatment of susceptible Escherichia coli cultures with low concentrations of dihydrostreptomycin leads to a decline in polysomes and a corresponding increase in 70S particles which behave as run-off ribosomes, as well as free 30S and 50S subunits. We have examined the timing and extent of these effects on rib...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.7.3.341

    authors： Kogut M,Prizant E

    更新日期：1975-03-01 00:00:00

  • Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.

    abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00973-06

    authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

    更新日期：2007-04-01 00:00:00

  • Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms.

    abstract：:Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofil...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02146-19

    authors： Reitzel RA,Rosenblatt J,Gerges BZ,Vargas-Cruz N,Raad II

    更新日期：2020-03-24 00:00:00

  • In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.

    abstract：:We investigated the evolution of resistance to the antifungal drug itraconazole in replicate populations of Aspergillus fumigatus that were founded from a strain with a genotype of sensitivity to a single drug and then propagated under uniform conditions. For each population, conidia were serially transferred 10 times...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.48.11.4405-4413.2004

    authors： da Silva Ferreira ME,Capellaro JL,dos Reis Marques E,Malavazi I,Perlin D,Park S,Anderson JB,Colombo AL,Arthington-Skaggs BA,Goldman MH,Goldman GH

    更新日期：2004-11-01 00:00:00

  • Deoxysugars as antituberculars and alpha-mannosidase inhibitors.

    abstract：:A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a com...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02715-13

    authors： Kashyap V,Sharma S,Singh V,Sharma SK,Saquib M,Srivastava R,Shaw AK

    更新日期：2014-06-01 00:00:00

  • Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.

    abstract：:Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma bet...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1128/AAC.00673-07

    authors： Adjei GO,Kristensen K,Goka BQ,Hoegberg LC,Alifrangis M,Rodrigues OP,Kurtzhals JA

    更新日期：2008-12-01 00:00:00

  • In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine Sensitivity.

    abstract：:Malaria control is hindered by the evolution and spread of resistance to antimalarials, necessitating multiple changes to drug policies over time. A comprehensive antimalarial drug resistance surveillance program is vital for detecting the potential emergence of resistance to antimalarials, including current artemisin...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01894-15

    authors： Lucchi NW,Komino F,Okoth SA,Goldman I,Onyona P,Wiegand RE,Juma E,Shi YP,Barnwell JW,Udhayakumar V,Kariuki S

    更新日期：2015-12-01 00:00:00

  • Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution.

    abstract：:A total of 18 strains of Mycobacterium fortuitum, 15 strains of M. chelonei, and 31 strains of M. chelonei-like organisms were tested by both broth microdilution and agar dilution to determine their susceptibility to 34 antimicrobial agents. All strains grew well enough in cation-supplemented Mueller-Hinton broth for ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.22.2.186

    authors： Swenson JM,Thornsberry C,Silcox VA

    更新日期：1982-08-01 00:00:00

  • Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin.

    abstract：:Actithiazic acid and alpha-methyldethiobiotin inhibited the conversion of dethiobiotin to biotin resting-cell suspensions of Escherichia coli. The concentrations which effected 50% inhibition were 0.45 and 1.1 microM for actithiazic acid and alpha-methyldethiobiotin, respectively. Cells grown in low concentrations of ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.21.1.5

    authors： Eisenberg MA,Hsiung SC

    更新日期：1982-01-01 00:00:00

  • Penicillin-binding proteins in a Staphylococcus aureus strain resistant to specific beta-lactam antibiotics.

    abstract：:The penicillin-binding proteins (PBPs) of a clinical isolate of Staphylococcus aureus specifically resistant to oral cephalosporins were compared with those of a susceptible strain. In the resistant strain, PBP3 (75,000 molecular weight) was missing or had substantially (greater than 100-fold) reduced affinity for pen...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.22.1.172

    authors： Georgopapadakou NH,Smith SA,Bonner DP

    更新日期：1982-07-01 00:00:00

  • Effect of fluconazole on the steady-state pharmacokinetics of delavirdine in human immunodeficiency virus-positive patients.

    abstract：:Fluconazole, an inhibitor of certain human cytochrome P-450 isozymes, is used for the prevention and treatment of a broad range of fungal infections that predominantly affect immunocompromised individuals. This study evaluated the influence of fluconazole on the steady-state pharmacokinetics of delavirdine, a nonnucle...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1128/AAC.41.9.1892

    authors： Borin MT,Cox SR,Herman BD,Carel BJ,Anderson RD,Freimuth WW

    更新日期：1997-09-01 00:00:00

  • Interaction of oxyimino beta-lactams with a class C beta-lactamase and a mutant with a spectrum extended to beta-lactams.

    abstract：:The class C beta-lactamase of Citrobacter freundii GN346 is a typical cephalosporinase comprising 361 amino acids, and substitution of the glutamic acid at position 219 in the enzyme by lysine was previously shown to broaden its substrate spectrum to oxyimino beta-lactams (K. Tsukamoto, R. Ohno, and T. Sawai, J. Bacte...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.38.6.1374

    authors： Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

    更新日期：1994-06-01 00:00:00

  • Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection.

    abstract：:GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Streptococcus pneumoniae a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01842-15

    authors： Hoover J,Lewandowski T,Straub RJ,Novick SJ,DeMarsh P,Aubart K,Rittenhouse S,Zalacain M

    更新日期：2015-10-19 00:00:00

  • Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid.

    abstract：:The MICs of ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid for clinical isolates of Mycobacterium kansasii were determined by the radiometric (BACTEC) method. All drugs except azithromycin elicited MICs for 90% of the strains tested that were lower than previously reported achievable maximum c...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.37.9.1997

    authors： Witzig RS,Franzblau SG

    更新日期：1993-09-01 00:00:00

  • Antimalarial action of hydroxamate-based iron chelators and potentiation of desferrioxamine action by reversed siderophores.

    abstract：:Hydroxamate-based chelators of iron are potent inhibitors of in vitro growth of Plasmodium falciparum. Two types of such chelators, the natural desferrioxamine and the synthetic reversed siderophore RSFileum2, are prototypes of antimalarial agents whose action spectra differ in the speed of action, stage dependence, a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.39.1.61

    authors： Golenser J,Tsafack A,Amichai Y,Libman J,Shanzer A,Cabantchik ZI

    更新日期：1995-01-01 00:00:00

  • Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance.

    abstract：:The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found that the loss of the putative calcium-dependent protein-encoding gene algA caus...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02101-16

    authors： Wei X,Chen P,Gao R,Li Y,Zhang A,Liu F,Lu L

    更新日期：2016-12-27 00:00:00

  • Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients.

    abstract：:The pharmacokinetics of cefepime were studied in 12 adult patients in intensive care units during continuous venovenous hemofiltration (CVVH) or continuous venovenous hemodiafiltration (CVVHDF) with a Multiflow60 AN69HF 0.60-m(2) polyacrylonitrile hollow-fiber membrane (Hospal Industrie, Meyzieu, France). Patients (me...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1128/AAC.45.11.3148-3155.2001

    authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

    更新日期：2001-11-01 00:00:00

  • Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.

    abstract：:Retrocyclins are humanized versions of the -defensin peptides expressed by the leukocytes of several nonhuman primates. Previous studies, performed in serum-free media, determined that retrocyclins 1 (RC1) and RC2 could prevent successful germination of Bacillus anthracis spores, kill vegetative B. anthracis cells, an...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00267-11

    authors： Welkos S,Cote CK,Hahn U,Shastak O,Jedermann J,Bozue J,Jung G,Ruchala P,Pratikhya P,Tang T,Lehrer RI,Beyer W

    更新日期：2011-09-01 00:00:00

  • Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.

    abstract：:Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapte...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00241-08

    authors： Preechapornkul P,Imwong M,Chotivanich K,Pongtavornpinyo W,Dondorp AM,Day NP,White NJ,Pukrittayakamee S

    更新日期：2009-04-01 00:00:00

  • Population pharmacokinetics of peramivir in healthy volunteers and influenza patients.

    abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00799-15

    authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

    更新日期：2015-11-01 00:00:00

  • OXA-14, another extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa.

    abstract：:Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta-lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate betwe...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.39.8.1881

    authors： Danel F,Hall LM,Gur D,Livermore DM

    更新日期：1995-08-01 00:00:00