Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

abstract：:The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile...

journal_title：Antimicrobial agents and chemotherapy

authors： Seiler P,Enderlin-Paput M,Pfaff P,Weiss M,Ritz D,Clozel M,Locher HH

更新日期：2015-10-26 00:00:00

abstract：:Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC D...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdugo D,Fallows D,Ahuja S,Schluger N,Kreiswirth B,Mathema B

更新日期：2015-10-01 00:00:00

abstract：:A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

journal_title：Antimicrobial agents and chemotherapy

authors： Alonso A,Sanchez P,Martínez JL

更新日期：2000-07-01 00:00:00

abstract：:Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transami...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormack WM,George H,Donner A,Kodgis LF,Alpert S,Lowe EW,Kass EH

更新日期：1977-11-01 00:00:00

abstract：:Mongrel dogs with ascites created by inferior vena cava ligation were given cephalothin, cephaloridine, cefazolin, and cefamandole to evaluate the effect of protein binding and serum pharmacokinetics on the distribution of cephalosporins into ascitic fluid. Antibiotics were given intramuscularly (15 mg/kg) every 4 h f...

journal_title：Antimicrobial agents and chemotherapy

authors： Gerding DN,Peterson LR,Legler DC,Hall WH,Schierl EA

更新日期：1978-08-01 00:00:00

abstract：:Cefazolin was added to dialysis fluid in nine patients with renal failure undergoing peritoneal dialysis with 2 liters/h per exchange. With 50 mg/liter (three patients), the first measurable mean serum concentration was 3.7 mug/ml (range, 2.4 to 4.9 mug/ml) after three exchanges and was 30.3 mug/ml (range, 13.3 to 44....

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye D,Wenger N,Agarwal B

更新日期：1978-09-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen associated with nosocomial pneumonia and is an increasing threat for severe community-acquired pneumonia. We have now investigated the role of interleukin-12 (IL-12) in protective immunity against lung infection with MRSA. The importance of IL-12 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen QT,Furuya Y,Roberts S,Metzger DW

更新日期：2015-10-01 00:00:00

abstract：:Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vignaroli C,Biavasco F,Varaldo PE

更新日期：2006-07-01 00:00:00

abstract：:Central-line-associated bloodstream infections are increasingly recognized to be associated with intraluminal microbial biofilms, and effective measures for the prevention and treatment of bloodstream infections remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (AC...

journal_title：Antimicrobial agents and chemotherapy

authors： Chandra J,Long L,Isham N,Mukherjee PK,DiSciullo G,Appelt K,Ghannoum MA

更新日期：2018-07-27 00:00:00

abstract：:Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams JA,Krizsanovich-Williams K

更新日期：1977-09-01 00:00:00

abstract：:Clinical isolates of Klebsiella pneumoniae resistant to carbapenems are being isolated with increasing frequency. Loss of the expression of the major nonspecific porins OmpK35/36 is a frequent feature in these isolates. In this study, we looked for porins that could compensate for the loss of the major porins in carba...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Sureda L,Doménech-Sánchez A,Barbier M,Juan C,Gascó J,Albertí S

更新日期：2011-10-01 00:00:00

abstract：:Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Sáez-Llorens X,Macias M,Maiya P,Pineros J,Jafri HS,Chatterjee A,Ruiz G,Raghavan J,Bradshaw SK,Kartsonis NA,Sun P,Strohmaier KM,Fallon M,Bi S,Stone JA,Chow JW

更新日期：2009-03-01 00:00:00

abstract：:Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Joanny F,Held J,Mordmüller B

更新日期：2012-11-01 00:00:00

abstract：:The activity of cefotaxime, either alone or combined with an aminoglycoside, was determined against 50 isolates of Pseudomonas aeruginosa, of which 50, 33, and 10 were resistant to gentamicin, tobramycin, and amikacin, respectively. Cefotaxime inhibited 34 isolates at a concentration of 16 microgram/ml and all isolate...

journal_title：Antimicrobial agents and chemotherapy

authors： Murray PR

更新日期：1980-03-01 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:The aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obtained 30 min (n = 5)...

journal_title：Antimicrobial agents and chemotherapy

authors： Semoun O,Marchand S,Grégoire N,Lamarche I,Adier C,Laroche L,Goldschmidt P,Couet W

更新日期：2012-07-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00

abstract：:Biofilm formation is an important virulence factor that allows bacteria to resist host responses and antibacterial agents. The aim of the study was to assess the in vitro activities of several antimicrobials alone or in combination against two Staphylococcus aureus isolates in a novel pharmacokinetic/pharmacodynamic (...

journal_title：Antimicrobial agents and chemotherapy

authors： Parra-Ruiz J,Vidaillac C,Rose WE,Rybak MJ

更新日期：2010-10-01 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131) is a pandemic clonal lineage that is responsible for the global increase in fluoroquinolone resistance and extended-spectrum-β-lactamase (ESBL) producers. The members of ST131 clade C, especially subclades C2 and C1-M27, are associated with ESBLs. We developed a multiplex con...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura Y,Pitout JDD,Peirano G,DeVinney R,Noguchi T,Yamamoto M,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2017-07-25 00:00:00

abstract：:An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination o...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Harris B,Carter WT,Finegold SM

更新日期：1985-05-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:We used the Tn10-encoded Tet repressor, which has a highly specific binding capacity for tetracycline, to probe contacts between the drug and protein by chemical interference studies of the antibiotic. For that purpose, the equilibrium association constants of modified tetracyclines with the Tet repressor and Mg2+ cat...

journal_title：Antimicrobial agents and chemotherapy

authors： Degenkolb J,Takahashi M,Ellestad GA,Hillen W

更新日期：1991-08-01 00:00:00

abstract：:Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： van Belkum A,Fahal AH,van de Sande WW

更新日期：2011-04-01 00:00:00

abstract：:The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin doses of 0 to 100 mg/kg of body weight and sacrificed 7 days later. The maximal decline in kidney fungal burden was 5.8 l...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T,Drusano GL,Liu W,Kulawy RW,Fregeau C,Hsu V,Louie A

更新日期：2007-03-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00

abstract：:The in vitro susceptibilities of 98 isolates of JK diphtheroids to teichomycin, vancomycin, and eight other antibiotics was investigated. Teichomycin and vancomycin were extremely active against all the isolates tested. The 90% minimal inhibitory concentrations for teichomycin and vancomycin were 1.56 and 0.78 microgr...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Fainstein V,LeBlanc B,Bodey GP

更新日期：1983-08-01 00:00:00

abstract：:Antiviral drugs do not currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. We conducted high-throughput molecular screening and identified a structurally diverse set of compounds that inhibit the replication of coxsackievirus B3, a commonly encountered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zuo J,Kye S,Quinn KK,Cooper P,Damoiseaux R,Krogstad P

更新日期：2015-12-28 00:00:00

abstract：:The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cherubin CE,Corrado ML,Sierra MF,Gombert ME,Shulman M

更新日期：1981-10-01 00:00:00

abstract：:Penicillin-binding protein 5 (PBP5) is one of the most abundant PBPs in Pseudomonas aeruginosa. Although its main function is that of a cell wall dd-carboxypeptidase, it possesses sufficient β-lactamase activity to contribute to the ability of P. aeruginosa to resist the antibiotic activity of the β-lactams. The study...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith JD,Kumarasiri M,Zhang W,Hesek D,Lee M,Toth M,Vakulenko S,Fisher JF,Mobashery S,Chen Y

更新日期：2013-07-01 00:00:00