OXA-14, another extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa.

abstract：:Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent...

journal_title：Antimicrobial agents and chemotherapy

authors： Peltroche-Llacsahuanga H,Goyard S,d'Enfert C,Prill SK,Ernst JF

更新日期：2006-10-01 00:00:00

abstract：:MprF is responsible for the lysinylation of phosphatidylglycerol (PG) to synthesize the positively charged phospholipid (PL) species, lysyl-PG (L-PG). It has been proposed that the single-nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) are associated with a gain-in-function phenotype in terms ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Mishra NN,Chen L,Kreiswirth BN,Rubio A,Yang SJ

更新日期：2015-08-01 00:00:00

abstract：:Hematogenous Candida meningoencephalitis (HCME) is a serious infection in premature neonates. Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp., but its efficacy and optimal regimens for human neonates with HCME are not known. A well-validated rabbit model of HCME was used to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Warn PA,Livermore J,Howard S,Felton TW,Sharp A,Gregson L,Goodwin J,Petraitiene R,Petraitis V,Cohen-Wolkowiez M,Walsh TJ,Benjamin DK Jr,Hope WW

更新日期：2012-02-01 00:00:00

abstract：:The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

更新日期：2017-06-27 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Limburg E,Gahlmann R,Kroll HP,Beyer D

更新日期：2004-02-01 00:00:00

abstract：:Pharmacokinetic modeling has often been applied to evaluate vancomycin pharmacokinetics in neonates. However, clinical application of the model-based personalized vancomycin therapy is still limited. The objective of the present study was to evaluate the clinical utility and safety of a model-based patient-tailored do...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroux S,Jacqz-Aigrain E,Biran V,Lopez E,Madeleneau D,Wallon C,Zana-Taïeb E,Virlouvet AL,Rioualen S,Zhao W

更新日期：2016-03-25 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:Ten (0.05%) of 18,628 strains of Streptococcus pyogenes isolated from clinical specimens in the 3 years 1968 to 1970 were resistant to lincomycin and erythromycin. All 10 strains were highly resistant to lincomycin, having minimal inhibitory concentration (MIC) values of 200 mug/ml. There were two degrees of resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon JM,Lipinski AE

更新日期：1972-04-01 00:00:00

abstract：:Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

journal_title：Antimicrobial agents and chemotherapy

authors： El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

更新日期：2015-01-01 00:00:00

abstract：:The pore-forming microcin E492 was purified by solid-phase extraction and reversed-phase high-pressure liquid chromatography. Its molecular mass was 7,886 Da. The entire 84-amino-acid sequence was determined. There is no postranslational modification in the secreted microcin, and the sequence has homologies with the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pons AM,Zorn N,Vignon D,Delalande F,Van Dorsselaer A,Cottenceau G

更新日期：2002-01-01 00:00:00

abstract：:A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

journal_title：Antimicrobial agents and chemotherapy

authors： Alonso A,Sanchez P,Martínez JL

更新日期：2000-07-01 00:00:00

abstract：:MICs of daptomycin, linezolid, and vancomycin against 212 isolates, including Listeria monocytogenes and Pediococcus, Leuconostoc, Rhodococcus, and Nocardia spp., were determined by the broth microdilution method; daptomycin MICs were also determined by the Etest. Except with those for Leuconostoc spp., daptomycin Ete...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang YT,Liao CH,Teng LJ,Hsueh PR

更新日期：2007-04-01 00:00:00

abstract：:Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basic cellular processes of relevance to pathogenic mycobacteria. This study focused on the D-alanine racemase gene (alrA), which is involved in the synthesis of D-alanine, a basic component of peptidoglycan that forms the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chacon O,Feng Z,Harris NB,Cáceres NE,Adams LG,Barletta RG

更新日期：2002-01-01 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptom...

journal_title：Antimicrobial agents and chemotherapy

authors： Iwai Y,Ono H,Takeshima H,Yamaguchi N,Omura S

更新日期：1973-09-01 00:00:00

abstract：:ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae In this study, we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical is...

journal_title：Antimicrobial agents and chemotherapy

authors： Santos-Lopez A,Bernabe-Balas C,Ares-Arroyo M,Ortega-Huedo R,Hoefer A,San Millan A,Gonzalez-Zorn B

更新日期：2017-01-24 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

更新日期：2018-06-26 00:00:00

abstract：:The management of long-term central venous catheter (LTCVC) infections by multidrug-resistant (MDR) bacteria in cancer patient is a challenge. The objectives of this study were to analyze outcomes in cancer patients with LTCVC-associated infection, identify risks for unfavorable outcomes, and determine the impact of M...

journal_title：Antimicrobial agents and chemotherapy

authors： Freire MP,Pierrotti LC,Zerati AE,Benites L,da Motta-Leal Filho JM,Ibrahim KY,Araujo PH,Abdala E

更新日期：2018-08-27 00:00:00

abstract：:Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eron LJ,Toy C,Salsitz B,Scheer RR,Wood DL,Nadler PI

更新日期：1987-07-01 00:00:00

abstract：:Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious top...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti S,Cevini C,Bruno A,Penso G,Rama P,Scaglia M

更新日期：1998-09-01 00:00:00

abstract：:Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Because zinc stabilizes the mammalian superoxide dismutase, we postulated that cilastatin would also inhibit the dismutase. Cilastatin concentrations at levels threefold higher than those expected in urine, however, did not inhibit ...

journal_title：Antimicrobial agents and chemotherapy

authors： Proctor RA,Textor JA

更新日期：1985-11-01 00:00:00

abstract：:Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Felici A,Perilli M,Segatore B,Franceschini N,Setacci D,Oratore A,Stefani S,Galleni M,Amicosante G

更新日期：1995-06-01 00:00:00

abstract：:We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no di...

journal_title：Antimicrobial agents and chemotherapy

authors： Lionakis MS,Chamilos G,Lewis RE,Wiederhold NP,Raad II,Samonis G,Kontoyiannis DP

更新日期：2006-01-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:Azoles are widely used antifungals; however, their efficacy is compromised by fungistatic activity and selection of resistant strains during treatment. Recent studies demonstrated roles for the protein kinase C and calcium signaling pathways in modulating azole activity. Here we explored a role for the signaling pathw...

journal_title：Antimicrobial agents and chemotherapy

authors： Jain P,Akula I,Edlind T

更新日期：2003-10-01 00:00:00

abstract：:S. aureus combats cell wall antibiotic stress by altered gene expression mediated by various environmental signal sensors. In this study, we examined the transcriptional regulation of trfA, a gene related to mecA of Bacillus subtilis encoding an adaptor protein implicated in multiple roles, notably, proteolysis and ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Jousselin A,Kelley WL,Barras C,Lew DP,Renzoni A

更新日期：2013-07-01 00:00:00

abstract：:Despite the availability of >30 effective drugs for managing HIV-1 infection, no current therapy is curative, and long-term management is challenging owing to the emergence and spread of drug-resistant mutants. Identification of drugs against novel HIV-1 targets would expand the current treatment options and help to c...

journal_title：Antimicrobial agents and chemotherapy

authors： Halambage UD,Wong JP,Melancon BJ,Lindsley CW,Aiken C

更新日期：2015-09-01 00:00:00