Screening and isolation of penicillinase inhibitor, KA-107.

Abstract:

:It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolated. The characteristics of this inhibitor were revealed by an in vitro test by using penicillinase derived from penicillin resistant Staphylococcus aureus, FS-1277. When KA-107 was used in combination with penicillin-G, ampicillin, d- or l-phenethicillin, the growth inhibitory activity of these penicillins was maintained.

authors

Iwai Y,Ono H,Takeshima H,Yamaguchi N,Omura S

doi

10.1128/aac.4.3.222

subject

Has Abstract

pub_date

1973-09-01 00:00:00

pages

222-5

issue

3

eissn

0066-4804

issn

1098-6596

journal_volume

4

pub_type

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