Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.

abstract：:Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically...

journal_title：Antimicrobial agents and chemotherapy

authors： Forrest A,Garonzik SM,Thamlikitkul V,Giamarellos-Bourboulis EJ,Paterson DL,Li J,Silveira FP,Nation RL

更新日期：2017-10-24 00:00:00

abstract：:A combination of 3 g of ticarcillin and 200 mg of clavulanic acid was administered intravenously to six healthy male volunteers, after which the concentrations of these agents in serum and blister fluid were measured. The ratio of the two drugs in serum varied from 15:1 (ticarcillin-clavulanic acid) at the time of adm...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett S,Wise R,Weston D,Dent J

更新日期：1983-06-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:T-20EK is a novel fusion inhibitor designed to have enhanced α-helicity over T-20 (enfuvirtide) through engineered electrostatic interactions between glutamic acid (E) and lysine (K) substitutions. T-20EK efficiently suppresses wild-type and T-20-resistant variants. Here, we selected T-20EK-resistant variants. A combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimane K,Kawaji K,Miyamoto F,Oishi S,Watanabe K,Sakagami Y,Fujii N,Shimura K,Matsuoka M,Kaku M,Sarafianos SG,Kodama EN

更新日期：2013-08-01 00:00:00

abstract：:The mechanisms of fluconazole resistance in three clinical isolates of Candida krusei were investigated. Analysis of sterols of organisms grown in the absence and presence of fluconazole demonstrated that the predominant sterol of C. krusei is ergosterol and that fluconazole inhibits 14alpha-demethylase in this organi...

journal_title：Antimicrobial agents and chemotherapy

authors： Orozco AS,Higginbotham LM,Hitchcock CA,Parkinson T,Falconer D,Ibrahim AS,Ghannoum MA,Filler SG

更新日期：1998-10-01 00:00:00

abstract：:A potential pharmacokinetic interaction between rifampin (Rimactan, Rifadin) and zidovudine (AZT, Retrovir) was investigated in the population of human immunodeficiency virus-infected patients at our hospital. The results from four patients who were on long-term (> or = 6 months) combination therapy with zidovudine an...

journal_title：Antimicrobial agents and chemotherapy

authors： Burger DM,Meenhorst PL,Koks CH,Beijnen JH

更新日期：1993-07-01 00:00:00

abstract：:Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Zhang Y,Deretic V,Musser JM

更新日期：1997-03-01 00:00:00

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:A biodegradable system of poly-D,L-dilactide releasing ciprofloxacin was assessed in a Pseudomonas aeruginosa osteomyelitis model after inoculation of the test pathogen into the left tibia of 76 New Zealand White rabbits; 31 were controls (group A), and 45 were implanted with the polymer at the infection site (group B...

journal_title：Antimicrobial agents and chemotherapy

authors： Kanellakopoulou K,Thivaios GC,Kolia M,Dontas I,Nakopoulou L,Dounis E,Giamarellos-Bourboulis EJ,Andreopoulos A,Karagiannakos P,Giamarellou H

更新日期：2008-07-01 00:00:00

abstract：:PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

更新日期：2005-08-01 00:00:00

abstract：:Thirty-nine adult patients with human immunodeficiency virus infection and oral candidiasis were randomly assigned to receive either one fluconazole capsule (100 mg) or five clotrimazole troches (10 mg each) daily for 14 days. Among 36 evaluable patients, clinical resolution rates were 100 and 65%, respectively (P = 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Koletar SL,Russell JA,Fass RJ,Plouffe JF

更新日期：1990-11-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:The spectrum of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase (RT) mutations selected by antiretroviral (ARV) drugs requires ongoing reassessment as ARV treatment patterns evolve and increasing numbers of protease and RT sequences of different viral subtypes are published. Accordingly,...

journal_title：Antimicrobial agents and chemotherapy

authors： Shahriar R,Rhee SY,Liu TF,Fessel WJ,Scarsella A,Towner W,Holmes SP,Zolopa AR,Shafer RW

更新日期：2009-11-01 00:00:00

abstract：:MUC7 12-mer-L exhibits potent in vitro antifungal activity in low-ionic-strength buffers. In this study, we investigated the anticandidal activity and stability of MUC7 12-mer-L and its all-D-amino-acid isomer, along with Hsn5 12-mer (P113) and magainin-II, in human clarified and unclarified saliva in the absence or p...

journal_title：Antimicrobial agents and chemotherapy

authors： Wei GX,Bobek LA

更新日期：2005-06-01 00:00:00

abstract：:The entry of an antibiotic into phagocytes is a prerequisite for its intracellular bioactivity against susceptible facultative or obligatory intracellular microorganisms. Brodimoprim is a dimethoxybenzylpyrimidine that has recently entered into clinical use, and its uptake into and elimination from human polymorphonuc...

journal_title：Antimicrobial agents and chemotherapy

authors： Braga PC,Dal Sasso M,Maci S,Bondiolotti G,Fonti E,Reggio S

更新日期：1996-10-01 00:00:00

abstract：:MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KR...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Saito H,Fujii K,Sato K,Hidaka T

更新日期：1993-01-01 00:00:00

abstract：:Nonpregnant and pregnant guinea pigs in the last third of gestation were injected intramuscularly with 4 mg of gentamicin per kg, and drug concentrations in plasma were determined by radioimmunoassay at several intervals after injection. The maximum gentamicin concentration was lower in pregnant than in nonpregnant an...

journal_title：Antimicrobial agents and chemotherapy

authors： Lelievre-Pegorier M,Sakly R,Meulemans A,Merlet-Benichou C

更新日期：1985-10-01 00:00:00

abstract：:The transfer of DNA between Enterococcus faecium strains has been characterized both by the movement of well-defined genetic elements and by the large-scale transfer of genomic DNA fragments. In this work, we report on the whole-genome analysis of transconjugants resulting from mating events between the vancomycin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Solache M,Lebreton F,McLaughlin RE,Whiteaker JD,Gilmore MS,Rice LB

更新日期：2016-09-23 00:00:00

abstract：:We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins LA,Wennersten CB,Ferraro MJ,Moellering RC Jr,Eliopoulos GM

更新日期：1994-01-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G

更新日期：2004-10-01 00:00:00

abstract：:Optimal doses for antituberculosis (anti-TB) drugs in children have yet to be established. In 2010, the World Health Organization (WHO) recommended revised dosages of the first-line anti-TB drugs for children. Pharmacokinetic (PK) studies that investigated the adequacy of the WHO revised dosages to date have yielded c...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Alsultan A,Kwara A,Antwi S,Enimil A,Ortsin A,Dompreh A,Yang H,Wiesner L,Peloquin CA

更新日期：2018-08-27 00:00:00

abstract：:The Carba NP test was evaluated against a panel of 244 carbapenemase- and non-carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates. We confirmed the 100% specificity and positive predictive value of the test, but the sensitivity and negative predictive value were 72.5% and 69.2%, respectively...

journal_title：Antimicrobial agents and chemotherapy

authors： Tijet N,Boyd D,Patel SN,Mulvey MR,Melano RG

更新日期：2013-09-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00

abstract：:The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococca...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MS,Chai Y,Britigan BE,McKenna W,Adams J,Svendsen T,Bean K,Hassett DJ,Sparling PF

更新日期：1987-10-01 00:00:00

abstract：:The bla(TLA-1) gene encoding an extended-spectrum beta-lactamase was identified in 11 enterobacterial isolates from Mexico City, Mexico. This gene was located on different plasmids and plasmid types with different sizes and incompatibility groups. It was associated with a novel insertion sequence, ISCR20, encoding a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Berçot B,Poirel L,Silva-Sanchez J,Nordmann P

更新日期：2010-09-01 00:00:00