Systematic review and meta-analysis of antimicrobial treatment effect estimation in complicated urinary tract infection.


:Noninferiority trial design and analyses are commonly used to establish the effectiveness of a new antimicrobial drug for treatment of serious infections such as complicated urinary tract infection (cUTI). A systematic review and meta-analysis were conducted to estimate the treatment effects of three potential active comparator drugs for the design of a noninferiority trial. The systematic review identified no placebo trials of cUTI, four clinical trials of cUTI with uncomplicated urinary tract infection as a proxy for placebo, and nine trials with reports of treatment effect estimates for doripenem, levofloxacin, or imipenem-cilastatin. In the meta-analysis, the primary efficacy endpoint of interest was the microbiological eradication rate at the test-of-cure visit in the microbiological intent-to-treat population. The estimated eradication rates and corresponding 95% confidence intervals (CI) were 31.8% (26.5% to 37.2%) for placebo, 81% (77.7% to 84.2%) for doripenem, 79% (75.9% to 82.2%) for levofloxacin, and 80.5% (71.9% to 89.1%) for imipenem-cilastatin. The treatment effect estimates were 40.5% for doripenem, 38.7% for levofloxacin, 34.7% for imipenem-cilastatin, and 40.8% overall. These treatment effect estimates can be used to inform the design and analysis of future noninferiority trials in cUTI study populations.


Singh KP,Li G,Mitrani-Gold FS,Kurtinecz M,Wetherington J,Tomayko JF,Mundy LM




Has Abstract


2013-11-01 00:00:00














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    abstract::The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fick RB Jr,Alexander MR,Prince RA,Kasik JE

    更新日期:1987-05-01 00:00:00

  • Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.

    abstract::The gram-positive bacterium Streptomyces noursei ATCC 11455 produces a complex mixture of polyene macrolides generally termed nystatins. Although the structures for nystatins A(1) and A(3) have been reported, the identities of other components of the nystatin complex remain obscure. Analyses of the culture extract fro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bruheim P,Borgos SE,Tsan P,Sletta H,Ellingsen TE,Lancelin JM,Zotchev SB

    更新日期:2004-11-01 00:00:00

  • Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin.

    abstract::In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bougnoux ME,Dannaoui E,Accoceberry I,Angoulvant A,Bailly E,Botterel F,Chevrier S,Chouaki T,Cornet M,Dalle F,Datry A,Dupuis A,Fekkar A,Gangneux JP,Guitard J,Hennequin C,Le Govic Y,Le Pape P,Maubon D,Ranque S,Sautou

    更新日期:2016-07-22 00:00:00

  • Antimicrobial synergism against Mycobacterium avium complex strains isolated from patients with acquired immune deficiency syndrome.

    abstract::Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yajko DM,Kirihara J,Sanders C,Nassos P,Hadley WK

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  • Effect of pyrimido[1,6-a]benzimidazoles, quinolones, and Ca2+ on the DNA gyrase-mediated cleavage reaction.

    abstract::The quinolones inhibit the A subunit of DNA gyrase in the presence of Mg2+ by interrupting the DNA breakage and resealing steps, and the latter step is also retarded without quinolones if Mg2+ is replaced by Ca2+. Pyrimido[1,6-a]benzimidazoles have been found to represent a new class of potent DNA gyrase inhibitors wh...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gmünder H,Kuratli K,Keck W

    更新日期:1995-01-01 00:00:00

  • Use of novel boronic acid transition state inhibitors to probe substrate affinity in SHV-type extended-spectrum beta-lactamases.

    abstract::Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Thomson JM,Prati F,Bethel CR,Bonomo RA

    更新日期:2007-04-01 00:00:00

  • Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.

    abstract::L-nucleoside analogs are a new class of antiviral and anticancer agents, several of which are currently used in the clinic. The phosphorylation of these agents to the triphosphate form is thought to be important for exertion of their pharmacological activities. 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylur...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hu R,Li L,Degrève B,Dutschman GE,Lam W,Cheng YC

    更新日期:2005-05-01 00:00:00

  • Contribution of beta-lactamases to beta-lactam susceptibilities of susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates.

    abstract::The beta-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. A...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Segura C,Salvadó M,Collado I,Chaves J,Coira A

    更新日期:1998-06-01 00:00:00

  • In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.

    abstract::In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

    更新日期:2005-01-01 00:00:00

  • Synergism between penicillin, clindamycin, or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups.

    abstract::Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brook I,Coolbaugh JC,Walker RI,Weiss E

    更新日期:1984-01-01 00:00:00

  • The treatment response of chronically hepatitis C virus-infected patients depends on interferon concentration but not on interferon gene expression in peripheral blood mononuclear cells.

    abstract::The current treatment of chronic hepatitis C is based on pegylated alpha interferon (PEG-IFN-α) and ribavirin. The aim of this study was to identify biological and clinical variables related to IFN therapy that could predict patient outcome. The study enrolled 47 patients treated with PEG-IFN and ribavirin combined th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: François C,Coulouarn C,Descamps V,Castelain S,Brochot E,Baron A,Duchaussoy I,Capron D,Nguyen-Khac E,Duverlie G

    更新日期:2012-02-01 00:00:00

  • Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae.

    abstract::Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

    更新日期:2016-06-20 00:00:00

  • Sequential emergence of antibiotic resistance in enterococcal bloodstream isolates over 25 years.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

    更新日期:2002-11-01 00:00:00

  • Plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella krefeld strains isolated in the United States.

    abstract::Two types of transmissible plasmids which encode resistance to trimethoprim-sulfamethoxazole were found among five animal isolates of Salmonella krefeld. This is the first report of plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella strains isolated in the United States. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mathewson JJ,Murray BE

    更新日期:1983-03-01 00:00:00

  • Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program.

    abstract::A total of 104 carbapenemase (serine- and metallo-beta-lactamase [MbetaL])-producing strains of the Enterobacteriaceae family collected from 2000 to 2005 in medical centers distributed worldwide were tested against tigecycline and 25 comparators by reference broth microdilution methods. The most frequent carbapenemase...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Castanheira M,Sader HS,Deshpande LM,Fritsche TR,Jones RN

    更新日期:2008-02-01 00:00:00

  • Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection.

    abstract::Adult diabetic patients admitted to our Diabetes Center from September 1996 to January 1998 for severe, limb-threatening foot infection were consecutively enrolled in a prospective, randomized, controlled clinical study aimed at assessing the safety and efficacy of recombinant human granulocyte colony-stimulating fact...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Lalla F,Pellizzer G,Strazzabosco M,Martini Z,Du Jardin G,Lora L,Fabris P,Benedetti P,Erle G

    更新日期:2001-04-01 00:00:00

  • Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae.

    abstract::Meropenem-vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae The objective of these studies was to evaluate the efficacy of meropenem alone and in combination with vaborbactam in mouse thigh an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sabet M,Tarazi Z,Nolan T,Parkinson J,Rubio-Aparicio D,Lomovskaya O,Dudley MN,Griffith DC

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  • Antipicornavirus flavone Ro 09-0179.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ishitsuka H,Ohsawa C,Ohiwa T,Umeda I,Suhara Y

    更新日期:1982-10-01 00:00:00

  • Antimicrobial activity of betaine esters, quaternary ammonium amphiphiles which spontaneously hydrolyze into nontoxic components.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lindstedt M,Allenmark S,Thompson RA,Edebo L

    更新日期:1990-10-01 00:00:00

  • Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

    abstract::Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (defA) is not. Actin...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Margolis P,Hackbarth C,Lopez S,Maniar M,Wang W,Yuan Z,White R,Trias J

    更新日期:2001-09-01 00:00:00

  • Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors.

    abstract::Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Speck RR,Flexner C,Tian CJ,Yu XF

    更新日期:2000-05-01 00:00:00

  • HIV-positive nigerian adults harbor significantly higher serum lumefantrine levels than HIV-negative individuals seven days after treatment for Plasmodium falciparum infection.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chijioke-Nwauche I,van Wyk A,Nwauche C,Beshir KB,Kaur H,Sutherland CJ

    更新日期:2013-09-01 00:00:00

  • Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

    abstract::Simocyclinone D8, a coumarin derivative isolated from Streptomyces antibioticus Tü 6040, represents an interesting new antiproliferative agent. It was originally suggested that this drug recognizes the GyrA subunit and interferes with the gyrase catalytic cycle by preventing its binding to DNA. To further characterize...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sissi C,Vazquez E,Chemello A,Mitchenall LA,Maxwell A,Palumbo M

    更新日期:2010-01-01 00:00:00

  • The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

    abstract::Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably les...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

    更新日期:1992-01-01 00:00:00

  • Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells.

    abstract::Although fluoroquinolone antibiotics such as ciprofloxacin are able to gain access to lung tissue and both pleural and bronchial secretions, the characteristics of transport and cellular uptake of ciprofloxacin in human epithelial lung tissue remain obscure. We have chosen human airway epithelial (Calu-3) cells, recon...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cavet ME,West M,Simmons NL

    更新日期:1997-12-01 00:00:00

  • Reduced susceptibilities of Shigella sonnei strains isolated from patients with dysentery to fluoroquinolones.

    abstract::Seven clinical isolates of Shigella sonnei with reduced susceptibilities to fluoroquinolones (sparfloxacin, ciprofloxacin, and ofloxacin) were obtained. The MICs of fluoroquinolones against these S. sonnei strains were 16 to 32 times higher than those obtained against typical strains that are highly susceptible to the...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Horiuchi S,Inagaki Y,Yamamoto N,Okamura N,Imagawa Y,Nakaya R

    更新日期:1993-11-01 00:00:00

  • Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs.

    abstract::The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dumitru R,Hornby JM,Nickerson KW

    更新日期:2004-07-01 00:00:00

  • In vitro activities of MK-0826 and 16 other antimicrobials against Bacteroides fragilis group strains.

    abstract::The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Betriu C,Sánchez A,Palau ML,Gómez M,Picazo JJ

    更新日期:2001-08-01 00:00:00

  • SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia.

    abstract::Stenotrophomonas maltophilia is an emerging nosocomial pathogen that displays high-level intrinsic resistance to a variety of structurally unrelated antimicrobial agents. Efflux mechanisms are known to contribute to acquired multidrug resistance in this organism, and indeed, one such multidrug efflux system, SmeDEF, w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zhang L,Li XZ,Poole K

    更新日期:2001-12-01 00:00:00

  • Improved sodium hydroxide digestion method without homogenization for extraction of gentamicin from renal tissue.

    abstract::Recovery of gentamicin from renal cortical tissue (assayed by fluorescence polarization immunoassay) was highest (P less than 0.05) when using a sodium hydroxide (NaOH) digestion procedure without homogenization (90.0 +/- 5.4%), followed by homogenization with NaOH digestion (85.8 +/- 7.7%) and homogenization with tri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brown SA,Sugimoto K,Smith GG,Garry FB

    更新日期:1988-04-01 00:00:00