Beta-lactamase production and resistance to beta-lactam antibiotics in Nocardia.

abstract：:Mezlocillin is a new broad-spectrum semisynthetic penicillin that has shown encouraging in vitro activity against the infecting organisms most likely to cause mortality and morbidity in cancer patients receiving chemotherapy. The serum clearances and urine recoveries of mezlocillin, ampicillin, and carbenicillin were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Issell BF,Bodey GP,Weaver S

更新日期：1978-02-01 00:00:00

abstract：:The biliary excretion profile of cefixime was studied in 10 patients provided with T-tube drainage of the common bile duct after cholecystectomy. Following a single 200-mg oral dose, the peak concentration of cefixime in bile reached 56.9 +/- 70 mg/liter, approximately 20 times as high as the peak concentration in ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Westphal JF,Jehl F,Schloegel M,Monteil H,Brogard JM

更新日期：1993-07-01 00:00:00

abstract：:Candida albicans readily forms biofilms on the surface on indwelling medical devices, and these biofilms serve as a source of local and systemic infections. It is estimated that 27% of nosocomial C. albicans bloodstream infections are polymicrobial, with Staphylococcus aureus as the third most common organism isolated...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2009-09-01 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to multiple antibiotics did not affect the organism's susceptibility to the fluoroquinolones. The fluoroquinolones with in vitro...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC,Brown SD

更新日期：1996-10-01 00:00:00

abstract：:Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of breast cancer skin metastases and the oral treatment of leishmaniasis, although its mechanism of action remains unclear. Electron paramagnetic resonance (EPR) spectroscopy of a spin-labeled lipid and a thiol-specific spin lab...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

更新日期：2014-06-01 00:00:00

abstract：:A rapid, sensitive, and specific method of analysis for mezlocillin in serum and urine by high-pressure liquid chromatography is described. A solid-phase extraction column was used to remove interfering substances from samples before chromatography. Quantitation included the use of an internal standard, nafcillin. Mez...

journal_title：Antimicrobial agents and chemotherapy

authors： Fiore D,Auger FA,Drusano GL,Dandu VR,Lesko LJ

更新日期：1984-11-01 00:00:00

abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

journal_title：Antimicrobial agents and chemotherapy

authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

更新日期：2017-10-24 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:The activities of the purine acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir. DHPG was significantly more active than acyclovir against all but one (mouse cytomegalovirus) of the strains tested, with 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Freitas VR,Smee DF,Chernow M,Boehme R,Matthews TR

更新日期：1985-08-01 00:00:00

abstract：:Thirty-four infants and children ranging in age from 2.5 to 180 months (mean, 40 months) were treated with parenteral moxalactam (150 mg/kg per day) for suspected or proved bacterial infections outside the central nervous system. Six patients infected with Haemophilus influenzae b, nine infected with Staphylococcus au...

journal_title：Antimicrobial agents and chemotherapy

authors： Keyserling H,Feldman WE,Moffitt S,Manning N,Hollins M

更新日期：1982-06-01 00:00:00

abstract：:Ribavirin was inactive against the rotavirus of murine gastroenteritis; this may be due to the presence of guanosine inhibitors in the gut. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoub BD,Prozesky OW

更新日期：1977-10-01 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired infectious diarrhea. LFF571 is a novel inhibitor of the prokaryotic translation elongation factor Tu and is active against a range of bacterial species, including C. difficile. This first-in-human study investigated the safety and pharmacokinetics of sing...

journal_title：Antimicrobial agents and chemotherapy

authors： Ting LS,Praestgaard J,Grunenberg N,Yang JC,Leeds JA,Pertel P

更新日期：2012-11-01 00:00:00

abstract：:Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SC...

journal_title：Antimicrobial agents and chemotherapy

authors： Espedido BA,Steen JA,Barbagiannakos T,Mercer J,Paterson DL,Grimmond SM,Cooper MA,Gosbell IB,van Hal SJ,Jensen SO

更新日期：2012-06-01 00:00:00

abstract：:The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibilities of strains havin...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

更新日期：2008-02-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have potentially serious toxicities, and when given as intramuscular injections, dosing can be painful. Adv...

journal_title：Antimicrobial agents and chemotherapy

authors： Dharmadhikari AS,Kabadi M,Gerety B,Hickey AJ,Fourie PB,Nardell E

更新日期：2013-06-01 00:00:00

abstract：:Mycobacterium smegmatis DSM43756 inactivates rifampin, and the inactivated antibiotic product recovered from culture medium was ribosylated on the 23-OH group. To study this process, the gene responsible for the inactivation was expressed at high levels by the lac promoter in Escherichia coli conferring resistance to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Quan S,Imai T,Mikami Y,Yazawa K,Dabbs ER,Morisaki N,Iwasaki S,Hashimoto Y,Furihata K

更新日期：1999-01-01 00:00:00

abstract：:Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

journal_title：Antimicrobial agents and chemotherapy

authors： Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

更新日期：2020-12-16 00:00:00

abstract：:Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

更新日期：2010-07-01 00:00:00

abstract：:The in vitro susceptibilities of Actinobacillus actinomycetemcomitans to 14 antimicrobial combinations were studied by using the checkerboard titration technique. The results, expressed as the range of the fractional inhibitory concentration indices, were as follows: for metronidazole or its hydroxymetabolite combined...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavicić MJ,van Winkelhoff AJ,de Graaff J

更新日期：1992-12-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We re...

journal_title：Antimicrobial agents and chemotherapy

authors： Sherry L,Kean R,McKloud E,O'Donnell LE,Metcalfe R,Jones BL,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:The anti-human immunodeficiency virus type I (anti-HIV-1) effects of gamma-glutamylcysteine ethyl ester (gamma-GCE; TEI-2306) were examined in vitro. In initial studies using a vigorously HIV-1-producing human T-lymphocytic cell line, gamma-GCE displayed a novel biphasic repressive effect on chronic HIV-1 infection th...

journal_title：Antimicrobial agents and chemotherapy

authors： Kubota S,Shetty S,Zhang H,Kitahara S,Pomerantz RJ

更新日期：1998-05-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:SM-7338, a new carbapenem antibiotic, was demonstrated to have potent antibacterial activity against a broad spectrum of aerobes, including Staphylococcus aureus, beta-hemolytic streptococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp., members of the family Enterobacteriaceae, Pseudomonas spp., a...

journal_title：Antimicrobial agents and chemotherapy

authors： Edwards JR,Turner PJ,Wannop C,Withnell ES,Grindey AJ,Nairn K

更新日期：1989-02-01 00:00:00

abstract：:A47934, a peptide antibiotic produced by Streptomyces toyocaensis, belongs to the glycopeptide class of compounds which includes ristocetin and vancomycin. Incorporation studies with radioisotope-labeled substrates indicated that tyrosine, p-hydroxyphenylglycine, p-hydroxyphenylglyoxylate, acetate, and sulfate were ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Zmijewski MJ Jr,Briggs B,Logan R,Boeck LD

更新日期：1987-10-01 00:00:00