Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

abstract：:AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

journal_title：Antimicrobial agents and chemotherapy

authors： Shetty BV,Kosa MB,Khalil DA,Webber S

更新日期：1996-01-01 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00

abstract：:High-level azole resistance in the Darlington strain of Candida albicans was investigated by gene replacement in C. albicans and expression in Saccharomyces cerevisiae. We sequenced the ERG11 gene, which encodes the sterol C(14)alpha-demethylase, from our copy of the Darlington strain. Both alleles contained the histi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kakeya H,Miyazaki Y,Miyazaki H,Nyswaner K,Grimberg B,Bennett JE

更新日期：2000-11-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:The emergence of Neisseria gonorrhoeae isolates displaying resistance to antimicrobial agents is a major public health concern and a serious issue related to the occurrence of further untreatable gonorrhea infections. A retrospective analysis on 1,430 N. gonorrhoeae isolates, collected from 2003 through 2012, for anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Carannante A,Renna G,Dal Conte I,Ghisetti V,Matteelli A,Prignano G,Impara G,Cusini M,D'Antuono A,Vocale C,Antonetti R,Gaino M,Busetti M,Latino MA,Mencacci A,Bonanno C,Cava MC,Giraldi C,Stefanelli P

更新日期：2014-10-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

更新日期：2019-08-23 00:00:00

abstract：:Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofil...

journal_title：Antimicrobial agents and chemotherapy

authors： Reitzel RA,Rosenblatt J,Gerges BZ,Vargas-Cruz N,Raad II

更新日期：2020-03-24 00:00:00

abstract：:We recently reported the chromosomal location of the staphylococcal beta-lactamase gene in four strains of Enterococcus faecalis. Transfer of this gene from strain CH19 to an enterococcal recipient was accompanied by transfer of numerous other antimicrobial resistance determinants in the absence of detectable plasmid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Marshall SH

更新日期：1992-09-01 00:00:00

abstract：:We administered 2 g of ceftazidime intravenously every 8 h to cancer patients for the empiric therapy of febrile episodes. Ceftazidime was administered as monotherapy for patients with granulocyte counts in excess of 1,000/microliter. Febrile, neutropenic patients were randomized to also receive either piperacillin or...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Joshi J,Forrest A,Ruxer R,Standiford H,Leslie J,Wade J,Schimpff S

更新日期：1985-04-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:A reverse-phase, high-pressure liquid chromatographic method for the rapid and quantitative determination of ketoconazole has been developed. Drug levels from 0.5 to 10 microgram/ml can be determined in either yeast nitrogen base medium or human serum by using an octadecylsilane column. A retention time of 4.9 +/- 0.1...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrews FA,Peterson LR,Beggs WH,Crankshaw D,Sarosi GA

更新日期：1981-01-01 00:00:00

abstract：:The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreas...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Mellado E,Díaz-Guerra TM,Monzón A,Rodríguez-Tudela JL

更新日期：2001-06-01 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1973-06-01 00:00:00

abstract：:The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Abdelhamed AM,Good CE,Rhoads DD,Hujer KM,Hujer AM,Domitrovic TN,Rudin SD,Richter SS,van Duin D,Kreiswirth BN,Greco C,Fouts DE,Bonomo RA

更新日期：2018-12-21 00:00:00

abstract：:Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with N. gonorrhoeae are...

journal_title：Antimicrobial agents and chemotherapy

authors： Dukers-Muijrers NH,van Liere GA,Wolffs PF,Den Heijer C,Werner MI,Hoebe CJ

更新日期：2015-01-01 00:00:00

abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu S,Iyobe S,Mitsuhashi S

更新日期：1977-07-01 00:00:00

abstract：:The three direct-acting antiviral agent (3D) regimen is a novel combination of direct-acting antiviral agents (DAAs) that has proven effective for the treatment of hepatitis C virus (HCV) infection. Given the potential for coadministration in patients with human immunodeficiency virus infection, possible drug interact...

journal_title：Antimicrobial agents and chemotherapy

authors： Khatri A,Dutta S,Dunbar M,Podsadecki T,Trinh R,Awni W,Menon R

更新日期：2016-04-22 00:00:00

abstract：:The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoeksema M,Brul S,Ter Kuile BH

更新日期：2018-05-25 00:00:00

abstract：:Demethylchlortetracycline and, to a lesser extent, chlortetracycline were found to mediate the in vitro photoinactivation of Venezuelan equine encephalitis virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Esparza J,Pina CI,Novo E

更新日期：1976-07-01 00:00:00

abstract：:The standard disk diffusion method of Bauer et al. (Am. J. Clin. Pathol. 45:493-496, 1966; National Committee for Clinical Laboratory Standards, Performance standards for antimicrobial disc susceptibility tests, approved standard ASM-2, 2nd ed., 1979) was used to monitor the potency of 16 Autobac antibiotic elution di...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaydos JM,Harrington BJ

更新日期：1982-03-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:Difloxacin, A-56620, cefazolin, cefotaxime, ceftizoxime, cephapirin, SK&F 88070, and spectinomycin were used to compare the in vitro susceptibilities of Mycobacterium avium-M. intracellular isolates from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and diseased animals. Against the i...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne SK,Geddes GL,Isaac-Renton JL,Black WA

更新日期：1990-07-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:Serum and milk concentrations of rifamycin SV and rifampin were determined in lactating ewes after a single intravenous injection, and pharmacokinetic parameters were evaluated by the two-compartment open-system model. Rifampin was distributed throughout a greater volume than rifamycin SV and was eliminated more slowl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziv G,Sulman FG

更新日期：1974-02-01 00:00:00

abstract：:Amoxicillin and ampicillin were compared at a dose of 250 mg twice daily for 4 weeks to treat Salmonella typhi or Salmonella paratyphi A chronic bacteriuria with intermittent bacteremia. Eleven patients received amoxicillin, and 15 received ampicillin. Concentrations of the two drugs were measured in the urine and ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Bassily SB,Kilpatrick ME,Farid Z,Mikhail IA,El-Masry NA

更新日期：1981-11-01 00:00:00

abstract：:The trypanocidal action of green tea catechins against two different developmental stages of Trypanosoma cruzi is reported for the first time. This activity was assayed with the nonproliferative bloodstream trypomastigote and with the intracellular replicative amastigote parasite forms. An ethyl acetate fraction from ...

journal_title：Antimicrobial agents and chemotherapy

authors： Paveto C,Güida MC,Esteva MI,Martino V,Coussio J,Flawiá MM,Torres HN

更新日期：2004-01-01 00:00:00

abstract：:The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Towner KJ,Smith MA,Cowlishaw WA

更新日期：1983-04-01 00:00:00

abstract：:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP50...

journal_title：Antimicrobial agents and chemotherapy

authors： Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JY

更新日期：2005-12-01 00:00:00